Church of Nuestra Señora de Las Mercedes, Santo Domingo

The Memorial Museum of Dominican Resistance (Spanish: Museo Memorial de la Resistencia Dominicana) is a museum dedicated to the preservation of the history regarding the struggles of several generations of Dominicans during the dictatorship of Rafael L. Trujillo, including its background and its consequences. On July 31, 2009, the museum's collection was declared part of the Memory of the World Programme by UNESCO, in order to protect its preservation and facilitate its access through this program.

The Hospital San Nicolás de Bari is a preserved hospital ruin, and it was recognized by UNESCO for being the oldest hospital built in the Americas. Construction began in 1503 in Santo Domingo, Dominican Republic, at the behest of governor (and namesake of the hospital) Nicolás de Ovando. This grand project was in keeping with the desire to emulate European princely courts, and looked to Renaissance Italy for inspiration. At the time of its completion, the wards could accommodate up to 70 patients, comparable to the most advanced churches of Rome. It is likely that the model for the Hospital de San Nicolás was the large Ospedale di Santo Spirito in Sassia in Rome. The complex forms part of the Colonial Zone of Santo Domingo World Heritage Site.

La Puerta del Conde (The Count's Gate) was the main entrance to the fortified city of Santo Domingo (in present-day Dominican Republic), named to honor Governor Captain-General Bernardino de Meneses Bracamonte y Zapata, 1st Count of Peñalva, who during his tenure saved the city from a siege in 1655 by Englishmen General Robert Venables and Admiral William Penn amid the Third Anglo-Spanish War. The gate is part of a structure called El Baluarte del Conde (The Count's Bulwark), a fort in Ciudad Colonial, the colonial area of Santo Domingo. The fort was part of a larger system of fortifications that ran along a defensive wall which surrounded Ciudad Colonial. The Altar of the Fatherland and Independence Park are located there. Francisco del Rosario Sánchez, one of the Dominican Founding Fathers, proclaimed Dominican independence and raised the first Dominican Flag, on February 27, 1844.

Monasterio de San Francisco in Santo Domingo de Guzmán, Dominican Republic, is a monastery that was built between 1508–1560, with the arrival of the Franciscan fathers. The ruin is one of the most important of the city. It is located in the Colonial City of Santo Domingo and are part of UNESCO's 1990 declaration of the Colonial City as a World Heritage Site. The monastery was recognized by UNESCO for being the first and oldest monastery built in the Americas.

Parque Colón (Spanish pronunciation: [ˈpaɾke koˈlon]; lit. 'Columbus Park') is the central square of the Ciudad Colonial historic district of Santo Domingo, Dominican Republic. In its center stands a statue of Christopher Columbus, in whose honor the square was renamed in 1887. Previously the square was known as Plaza Mayor. Monuments bordering the square include the Catedral de Santa Maria la Menor, Santo Domingo's Palace, and the Palacio Borgella, which once hosted the Dominican Republic's Parliament. Calle del Conde, once the thriving commercial heart of Santo Domingo, starts from Parque Colón and runs to the Puerta del Conde. At the beginning of Calle del Conde is a bust of Bartholomew Columbus, Christopher's brother and the founder of Santo Domingo.

The Roman Catholic Metropolitan Archdiocese of Santo Domingo (Latin: Archidioecesis Metropolitae Sancti Dominici; Spanish: Arquidiócesis Metropolitana de Santo Domingo) is a Latin Metropolitan Archdiocese in the Dominican Republic. The see was erected 8 August 1511 as the Diocese of Santo Domingo and elevated to archdiocese on 12 February 1546.In recognition of the fact that the see was the first established in the New World, the Archbishop of Santo Domingo can use the title of Primate of the Indies, according to the bull of Pope Pius VII Divinis praeceptis issued on 28 November 1816 and ratified by the Concordat between the Holy See and the Dominican Republic signed on 16 June 1954.The archiepiscopal see is the Santa María la Menor cathedral, a World Heritage Site, dedicated to St. Mary of the Incarnation, which was designated a minor basilica by Pope Benedict XV in his apostolic letter Inter Americae on 14 June 1920.

The Cathedral of Santa María la Menor in the Colonial City of Santo Domingo is dedicated to St. Mary of the Incarnation. It is the first and oldest cathedral in the Americas, begun in 1504 and was completed in 1550. It is the cathedral of the Archbishop of Santo Domingo who has the honorary title of Primate of the Indies because this cathedral was the first Catholic diocese and the oldest cathedral established in the New World.The cathedral is fronted with a golden-tinted coral limestone façade. The building is Gothic, a notable example of real Gothic architecture outside Europe. There is also a treasury which has an excellent art collection of ancient woodcarvings, furnishings, funerary monuments, silver, and jewelry. It is located between Calle Arzobispo Merino and Isabel la Católica, next to Columbus Park in the city of Santo Domingo de Guzman.

Altar de la Patria, or Altar of the Homeland, is a white marble mausoleum in Santo Domingo, Dominican Republic that houses the remains of the founding fathers of the Dominican Republic: Juan Pablo Duarte, Francisco del Rosario Sánchez, and Ramón Matías Mella, collectively known as Los Trinitarios. Within the mausoleum there are statues of the founding fathers, carved by Italian sculptor Nicholas Arrighini; there is as well an "eternal flame" that is kept lit in memory of the patriots. The Altar is within the Baluatre del Conde and is the main attraction of the Parque Independencia (Independence Park).

National School of Visual Arts (Spanish: Escuela Nacional de Artes Visuales; ENAV) is an institution in the field of visual arts in the Dominican Republic. It was inaugurated on August 19, 1942. It is located in Santo Domingo.

The Casa del Cordón (Spanish for "House of the Cord") is a property located in the Colonial City of Santo Domingo, in the Dominican Republic. It is the oldest European stone house in the Americas and probably the first European two-story house. Its name is due to the chiseled sash-and-cord that it presents on its façade, which is associated with the Franciscan Order. It is located on Isabel la Católica street with the corner of Emiliano Tejera. In 1586, During the Francis Drake's incursion, the balance was installed inside this house with which the belongings that the inhabitants of the city had to deliver to the English pirate were weighed.This is an Isabelline Gothic and Mudéjar style building. It is part of the UNESCO World Heritage Site "Colonial City of Santo Domingo".

The National Pantheon was built from 1714 to 1746 by the Spaniard Geronimo Quezada y Garçon and was originally a Jesuit church. The structure was constructed in the neoclassic-renaissance style. Today, the structure stands as a national symbol of the Dominican Republic and serves as the final resting place of the Republic's most honored citizens.

The Santo Domingo Affair, or the Santo Domingo Crisis, refers to an incident in 1904 involving the United States and Dominican militia forces in the Dominican Republic. After the death of a seaman from the USS Yankee on February 1, the U.S. military launched a punitive expedition which routed the Dominican forces.