Monastery of San Francisco, Santo Domingo

The Casa del Cordón (Spanish for "House of the Cord") is a property located in the Colonial City of Santo Domingo, in the Dominican Republic. It is the oldest European stone house in the Americas and probably the first European two-story house. Its name is due to the chiseled sash-and-cord that it presents on its façade, which is associated with the Franciscan Order. It is located on Isabel la Católica street with the corner of Emiliano Tejera. In 1586, During the Francis Drake's incursion, the balance was installed inside this house with which the belongings that the inhabitants of the city had to deliver to the English pirate were weighed.This is an Isabelline Gothic and Mudéjar style building. It is part of the UNESCO World Heritage Site "Colonial City of Santo Domingo".

The Hospital San Nicolás de Bari is a preserved hospital ruin, and it was recognized by UNESCO for being the oldest hospital built in the Americas. Construction began in 1503 in Santo Domingo, Dominican Republic, at the behest of governor (and namesake of the hospital) Nicolás de Ovando. This grand project was in keeping with the desire to emulate European princely courts, and looked to Renaissance Italy for inspiration. At the time of its completion, the wards could accommodate up to 70 patients, comparable to the most advanced churches of Rome. It is likely that the model for the Hospital de San Nicolás was the large Ospedale di Santo Spirito in Sassia in Rome. The complex forms part of the Colonial Zone of Santo Domingo World Heritage Site.

The Plaza de España, also known as the Plaza de la Hispanidad, is a public square located in the historic district of Ciudad Colonial, Santo Domingo, Dominican Republic. To its north lies the historic Alcázar de Colón, dating back to 1514, and to the south, the Museo de las Casas Reales, built in 1511. The plaza is a popular gathering spot in the city, surrounded by a variety of restaurants and outdoor terraces. Due to its large size, it is also a popular venue for concerts and festivals.

The Santa Bárbara Military Cathedral is a colonial Eclectic Catholic cathedral dedicated to Saint Barbara that is located in the Ciudad Colonial of Santo Domingo, in the Dominican Republic. Its official name is Santa Iglesia Catedral Castrense Santa Bárbara de los Hombres de la Mar (Cathedral Military Saint Church Saint Barbara of the Men of the Sea). It is located in the Santa Bárbara de los Hidalgos Canteros sector, at the intersection of calle Isabel La Católica with calle General Gabino Puello, right on the edge of the Wall that protected the first Spanish viceroyalty in the New World.

The Reales Atarazanas (Royal Shipyards) is a waterside building that housed the shipyards, warehouses, customs house and tax offices of the old port of Santo Domingo, Dominican Republic. It was the property of the Spanish Crown. Begun in 1509, the Atarazanas is the oldest building of its type still standing in America, and one of a handful remaining in the Spanish world, amongst which are the Atarazanas Reales de Barcelona, in Barcelona, the Atarazanas Reales de Sevilla, in Seville, the Atarazanas del Grao in Valencia and the Royal Dockyard in Havana.The Atarazanas building is part of Colonial City of Santo Domingo World Heritage Site, and after restoration in 2018, today houses the Museo de las Atarazanas Reales, which reopened in December 2019 and exhibits artifacts recovered from underwater archaeology and other artifacts from colonial shipwrecks around Hispaniola island and the naval history of the Dominican Republic.

The Alcázar de Colón, or Columbus Alcazar is the first fortified European palace built in the Americas. It is located in the Dominican Republic's colonial area of Santo Domingo city, and forms part of the Ciudad Colonial UNESCO's World Heritage Site. It was built between 1510 and 1514 mostly in a Gothic and Renaissance style. It is the only known residence of a member of the Christopher Columbus family in the New World, his first-born son Diego Columbus, whose children Juana, Isabel, Luis and Christopher were born in the palace. Diego Columbus died in Spain in 1526 but María Álvarez de Toledo, his widow, remained there until her death in 1549. Three generations of the Columbus family inhabited the residence, possibly until the late 16th century. The Tapestry collection (spanning from the 15th to 17th centuries) is particularly important and unique in the Caribbean, and includes pieces produced by the Flemish Van Den Hecke family from cartouches created by Charles Le Brun. The Alcázar is the most visited museum in Santo Domingo.

The National Pantheon was built from 1714 to 1746 by the Spaniard Geronimo Quezada y Garçon and was originally a Jesuit church. The structure was constructed in the neoclassic-renaissance style. Today, the structure stands as a national symbol of the Dominican Republic and serves as the final resting place of the Republic's most honored citizens.

National School of Visual Arts (Spanish: Escuela Nacional de Artes Visuales; ENAV) is an institution in the field of visual arts in the Dominican Republic. It was inaugurated on August 19, 1942. It is located in Santo Domingo.

Parque Colón (Spanish pronunciation: [ˈpaɾke koˈlon]; lit. 'Columbus Park') is the central square of the Ciudad Colonial historic district of Santo Domingo, Dominican Republic. In its center stands a statue of Christopher Columbus, in whose honor the square was renamed in 1887. Previously the square was known as Plaza Mayor. Monuments bordering the square include the Catedral de Santa Maria la Menor, Santo Domingo's Palace, and the Palacio Borgella, which once hosted the Dominican Republic's Parliament. Calle del Conde, once the thriving commercial heart of Santo Domingo, starts from Parque Colón and runs to the Puerta del Conde. At the beginning of Calle del Conde is a bust of Bartholomew Columbus, Christopher's brother and the founder of Santo Domingo.

The Church of Nuestra Señora de Las Mercedes is a colonial Gothic church located in Santo Domingo, Dominican Republic. It is part of the UNESCO World Heritage Site "Colonial City of Santo Domingo". The construction of this religious building began in the year 1549, and was completed in 1616, built by Rodrigo de Liendo. It was an ancient seminary, later a monastery. This building was seriously damaged during the invasion of the English corsair Sir Francis Drake in 1586. The Church of Nuestra Señora de Las Mercedes has a wide vaulted nave with side chapels located between its buttresses. It has a high choir, an octagonal apse and a high altar in the Baroque style. It is notable for its wooden pulpit which is supported by a support in the form of a serpent demon.

The Roman Catholic Metropolitan Archdiocese of Santo Domingo (Latin: Archidioecesis Metropolitae Sancti Dominici; Spanish: Arquidiócesis Metropolitana de Santo Domingo) is a Latin Metropolitan Archdiocese in the Dominican Republic. The see was erected 8 August 1511 as the Diocese of Santo Domingo and elevated to archdiocese on 12 February 1546.In recognition of the fact that the see was the first established in the New World, the Archbishop of Santo Domingo can use the title of Primate of the Indies, according to the bull of Pope Pius VII Divinis praeceptis issued on 28 November 1816 and ratified by the Concordat between the Holy See and the Dominican Republic signed on 16 June 1954.The archiepiscopal see is the Santa María la Menor cathedral, a World Heritage Site, dedicated to St. Mary of the Incarnation, which was designated a minor basilica by Pope Benedict XV in his apostolic letter Inter Americae on 14 June 1920.

The Cathedral of Santa María la Menor in the Colonial City of Santo Domingo is dedicated to St. Mary of the Incarnation. It is the first and oldest cathedral in the Americas, begun in 1504 and was completed in 1550. It is the cathedral of the Archbishop of Santo Domingo who has the honorary title of Primate of the Indies because this cathedral was the first Catholic diocese and the oldest cathedral established in the New World.The cathedral is fronted with a golden-tinted coral limestone façade. The building is Gothic, a notable example of real Gothic architecture outside Europe. There is also a treasury which has an excellent art collection of ancient woodcarvings, furnishings, funerary monuments, silver, and jewelry. It is located between Calle Arzobispo Merino and Isabel la Católica, next to Columbus Park in the city of Santo Domingo de Guzman.