Roman Catholic Archdiocese of Santo Domingo

The Cathedral of Santa María la Menor in the Colonial City of Santo Domingo is dedicated to St. Mary of the Incarnation. It is the first and oldest cathedral in the Americas, begun in 1504 and was completed in 1550. It is the cathedral of the Archbishop of Santo Domingo who has the honorary title of Primate of the Indies because this cathedral was the first Catholic diocese and the oldest cathedral established in the New World.The cathedral is fronted with a golden-tinted coral limestone façade. The building is Gothic, a notable example of real Gothic architecture outside Europe. There is also a treasury which has an excellent art collection of ancient woodcarvings, furnishings, funerary monuments, silver, and jewelry. It is located between Calle Arzobispo Merino and Isabel la Católica, next to Columbus Park in the city of Santo Domingo de Guzman.

Parque Colón (Spanish pronunciation: [ˈpaɾke koˈlon]; lit. 'Columbus Park') is the central square of the Ciudad Colonial historic district of Santo Domingo, Dominican Republic. In its center stands a statue of Christopher Columbus, in whose honor the square was renamed in 1887. Previously the square was known as Plaza Mayor. Monuments bordering the square include the Catedral de Santa Maria la Menor, Santo Domingo's Palace, and the Palacio Borgella, which once hosted the Dominican Republic's Parliament. Calle del Conde, once the thriving commercial heart of Santo Domingo, starts from Parque Colón and runs to the Puerta del Conde. At the beginning of Calle del Conde is a bust of Bartholomew Columbus, Christopher's brother and the founder of Santo Domingo.

National School of Visual Arts (Spanish: Escuela Nacional de Artes Visuales; ENAV) is an institution in the field of visual arts in the Dominican Republic. It was inaugurated on August 19, 1942. It is located in Santo Domingo.

The Battle of Santo Domingo (1586) or the Capture of Santo Domingo was a military and naval action fought on 1 January 1586, of the recently declared Anglo-Spanish War that resulted in the assault and capture by English soldiers and sailors of the Spanish city of Santo Domingo governed by Cristóbal de Ovalle on the Spanish island of Hispaniola. The English were led by Francis Drake and was part of his Great Expedition to raid the Spanish New World in a kind of preemptive strike.: BC  The English soldiers then occupied the city for over a month and captured much booty along with a 25,000 ducat ransom before departing on 1 February.

The Ozama Fortress (Spanish: Fortaleza Ozama), also formerly known as the city wall's Homage tower. It is one of the surviving sections of the Walls of Santo domingo, which is recognized by UNESCO as being the oldest military construction of European origin in the Americas. It was built between 1502-1508 by the Spanish at the entrance to Santo Domingo's Ciudad Colonial, Dominican Republic, and overlooking the Ozama River. Named after this river, the castle, also referred to as "La Fortaleza" or "The Fortress". It was declared by UNESCO as a World Heritage Site, together with the other historical monuments of the Ciudad Colonial. The Ozama Fortress is part of the Colonial City of Santo Domingo. According to historians and architects, the construction of this monument lasted from 1502 to 1508, which was started by Governor Nicolás Ovando. During the 16th century, the 18-meter high tower was the highest European-built construction of the Americas.The construction of this fortress is designed in the form of a stone castle and still preserves its original architecture. Inside the fortress there are tunnels and dungeons where the prisoners were locked up, Christopher Columbus himself, one of the most important figures in the history of the Americas, was imprisoned in the Ozama fortress.

The National Pantheon was built from 1714 to 1746 by the Spaniard Geronimo Quezada y Garçon and was originally a Jesuit church. The structure was constructed in the neoclassic-renaissance style. Today, the structure stands as a national symbol of the Dominican Republic and serves as the final resting place of the Republic's most honored citizens.

The Hospital San Nicolás de Bari is a preserved hospital ruin, and it was recognized by UNESCO for being the oldest hospital built in the Americas. Construction began in 1503 in Santo Domingo, Dominican Republic, at the behest of governor (and namesake of the hospital) Nicolás de Ovando. This grand project was in keeping with the desire to emulate European princely courts, and looked to Renaissance Italy for inspiration. At the time of its completion, the wards could accommodate up to 70 patients, comparable to the most advanced churches of Rome. It is likely that the model for the Hospital de San Nicolás was the large Ospedale di Santo Spirito in Sassia in Rome. The complex forms part of the Colonial Zone of Santo Domingo World Heritage Site.

The Casa del Cordón (Spanish for "House of the Cord") is a property located in the Colonial City of Santo Domingo, in the Dominican Republic. It is the oldest European stone house in the Americas and probably the first European two-story house. Its name is due to the chiseled sash-and-cord that it presents on its façade, which is associated with the Franciscan Order. It is located on Isabel la Católica street with the corner of Emiliano Tejera. In 1586, During the Francis Drake's incursion, the balance was installed inside this house with which the belongings that the inhabitants of the city had to deliver to the English pirate were weighed.This is an Isabelline Gothic and Mudéjar style building. It is part of the UNESCO World Heritage Site "Colonial City of Santo Domingo".

The Plaza de España, also known as the Plaza de la Hispanidad, is a public square located in the historic district of Ciudad Colonial, Santo Domingo, Dominican Republic. To its north lies the historic Alcázar de Colón, dating back to 1514, and to the south, the Museo de las Casas Reales, built in 1511. The plaza is a popular gathering spot in the city, surrounded by a variety of restaurants and outdoor terraces. Due to its large size, it is also a popular venue for concerts and festivals.

The Port of Santo Domingo is located at the mouth of the marine entrance to the city of Santo Domingo, Dominican Republic. The port is suited for both turnaround and transit visits. It is located 16 kilometres from the port of Rio Haina.

Monasterio de San Francisco in Santo Domingo de Guzmán, Dominican Republic, is a monastery that was built between 1508–1560, with the arrival of the Franciscan fathers. The ruin is one of the most important of the city. It is located in the Colonial City of Santo Domingo and are part of UNESCO's 1990 declaration of the Colonial City as a World Heritage Site. The monastery was recognized by UNESCO for being the first and oldest monastery built in the Americas.

The Memorial Museum of Dominican Resistance (Spanish: Museo Memorial de la Resistencia Dominicana) is a museum dedicated to the preservation of the history regarding the struggles of several generations of Dominicans during the dictatorship of Rafael L. Trujillo, including its background and its consequences. On July 31, 2009, the museum's collection was declared part of the Memory of the World Programme by UNESCO, in order to protect its preservation and facilitate its access through this program.