Museum of History, Anthropology and Art of the University of Puerto Rico

The University of Puerto Rico (Spanish: Universidad de Puerto Rico, UPR) is the main public university system in the U.S. Commonwealth of Puerto Rico. It is a government-owned corporation with 11 campuses and approximately 44,200 students and approximately 4,450 faculty members. UPR has the largest and most diverse academic offerings in the commonwealth, with 472 academic programs of which 32 lead to a doctorate.

Universidad is a rapid transit station in San Juan agglomeration, Puerto Rico. It is located between Río Piedras and Piñero stations on the only line of the Tren Urbano system, in the Río Piedras area of the city of San Juan. The station is named after the University of Puerto Rico campus which it serves. The trial service ran in 2004, however, the regular service only started on 6 June 2005.

The Quadrangle (Spanish: El Cuadrángulo) is the heart and main quadrangle of the University of Puerto Rico, Río Piedras. Together with the Roosevelt Tower (La Torre), it is listed on the National Register of Historic Places as the University of Puerto Rico Tower and The Quadrangle, for its unique history which represents the union between Puerto Rican architecture with the Jeffersonian Neoclassical style often seen in American universities. It is famous for its lines of Puerto Rican royal palm (Roystonea borinquena) or palma real and the architecture of its surrounding buildings.The Quadrangle was designed by Puerto Rican architect Rafael Carmoega. The University of Puerto Rico Theater was first built on its eastern edge in 1939. The Quadrangle is the largest courtyard space in the University of Puerto Rico, Río Piedras campus. It is surrounding by buildings currently used by the University of Puerto Rico Administration and the College of Humanities. Its two most notable landmarks are the University Tower located on the western edge of the quad, and the University of Puerto Rico Theater, also known as the Roosevelt Theater, on its eastern edge. These buildings have an architectural style combining Spanish Revival styles such as Andalusian/Spanish Gothic and Baroque Revival. There is also a Banco Popular branch office and additional auditoriums.

Roosevelt Tower (officially: Franklin Delano Roosevelt Tower, Spanish: Torre Franklin Delano Roosevelt), more popularly known as La Torre, is a 173.54 feet (52.89 m) clock tower located above the main entrance to the Baldorioty de Castro Building in the University of Puerto Rico, Río Piedras Campus. The tower is also referred to as El Faro (The Lighthouse) and it is considered a symbol of the University of Puerto Rico and of higher education in Puerto Rico. The tower, along with the main historic quadrangle in campus, have been listed on the National Register of Historic Places since 1984.

The University of Puerto Rico, Río Piedras Campus (Spanish: Universidad de Puerto Rico, Recinto de Río Piedras; UPR-RP, or informally La IUPI) is a public land-grant research university in San Juan, Puerto Rico. It is the largest campus in the University of Puerto Rico system in terms of student population and it was Puerto Rico's first public university campus.The university serves more than 18,000 students, 20% of whom are graduate students, and grants an average of over 3,000 degrees a year. Its academic offerings range from the bachelor to the doctoral level with 70 undergraduate programs and 19 graduate degrees including 71 specializations in the basic disciplines and professional fields. UPR‐RP has consistently granted the largest number of doctorate degrees to Hispanic students under the United States jurisdiction.

Amparo is one of four subbarrios in barrio Universidad in the municipality of San Juan, Puerto Rico.

The Evangelical Seminary of Puerto Rico – or Seminario Evangélico de Puerto Rico (SEPR) in Spanish – is a private mainline Protestant seminary in Río Piedras, Puerto Rico. It offers graduate studies in religion. It was founded on September 11, 1919, by a group of theological schools and biblical institutes of the Protestant denominations that came to Puerto Rico after the Spanish–American War. This seminary is currently sponsored by the American Baptist Churches USA, the Iglesia Evangélica Unida de Puerto Rico (IEUPR) (affiliated until June 10, 2006, with the United Church of Christ), the Evangelical Lutheran Church in America, the United Methodist Church, and the Presbyterian Church (U.S.A.) and the Christian Church (Disciples of Christ). The seminary has retained its ties to the United Church of Christ even as the IEUPR has severed them. SEPR is accredited by the Association of Theological Schools in the United States and Canada, the Council on Higher Education of Puerto Rico, and the Middle States Association of Colleges and Schools.

The University High School, (Spanish: Escuela Secundaria de la Universidad de Puerto Rico) commonly referred to by its initials "UHS", in San Juan, Puerto Rico is a college preparatory laboratory high school operated by the Faculty of Education of the University of Puerto Rico. Located on the University of Puerto Rico, Río Piedras Campus, it provides education to approximately 514 students from 7th to 12th grade.

The Gay Pride Community Building (Spanish: Edificio Comunidad de Orgullo Gay de Puerto Rico), also known as Casa Orgullo ("Pride House"), is a historic site and former LGBT community center located in Río Piedras Pueblo (downtown Río Piedras) in San Juan, Puerto Rico.The building, a two-story reinforced concrete, Mediterranean Revival apartment house, first served as a meeting hall for the first gay/lesbian organization established in Puerto Rico, founded in 1974 as Comunidad de Orgullo Gay (Gay Pride Community). Inspired by the 1969 Stonewall Revolt, this was the first organized attempt to confront social, political and legal discrimination against the local LGBTQ community by pioneering resistance to discrimination through political action, educational programs, public awareness and social support to the community.Although Comunidad de Orgullo Gay disbanded in 1976, Casa Orgullo remains a symbol of gay rights in Puerto Rico, and it is considered a social historic site due to its importance in spearheading the gay liberation movement in the island. Forty years later, the building was listed in the National Register of Historic Places on May 2, 2016.The building is not open to the public, but it hosts a mural titled Flor de Parcha which depicts passion fruit flowers and can be appreciated from the street.

The Ladies Residence Hall of the University of Puerto Rico, Río Piedras (Spanish: Residencia de Señoritas de la Universidad de Puerto Rico, Río Piedras), also known today as the Old Residencia de Señoritas Building, is a historic Henry Klumb-designed building and former female dormitory of the University of Puerto Rico, Río Piedras campus (UPRRP). The Residencia de Señoritas was designed by famed architect Henry Klumb, a student of Frank Lloyd Wright, in the Modern style with additional architectural elements inspired in the Spanish Revival style. The building, commissioned by university chancellor Jaime Benítez Rexach, was constructed to accommodate a rapidly increasing student enrollment during a post-World War II developmental period induced by Operation Bootstrap (Operación Manos a la Obra). Although the residence hall was originally intended to be female-only, it became open to both male and female students in the years before the opening of larger residence halls across campus. The building today hosts the administrative and management offices for janitorial and infrastructural services of the UPRRP. It was added to National Register of Historic Places in 2018 due to its distinction as a superb example of International mid-century modern style in Puerto Rico.

Río Piedras is a rapid transit station in the San Juan Metropolitan Area, Puerto Rico. It is located between Cupey and Universidad stations on the only line of the Tren Urbano system, in the downtown area of Río Piedras (Río Piedras Pueblo), in the city of San Juan. The station is named after Río Piedras where it is located, itself named after the Piedras River which crosses the area. The trial service ran in 2004, however, the regular service only started on 6 June 2005.

Río Piedras Antiguo is one of the 6 subbarrios of Pueblo, a barrio in San Juan, Puerto Rico. It was, at one time, a subdivision of Río Piedras, a former municipality of Puerto Rico.