Residencia de Señoritas Building

The College of Natural Sciences of the University of Puerto Rico, Río Piedras (Spanish: Universidad de Puerto Rico, Recinto de Río Piedras), was established in 1943. It is one of several colleges that make up the University of Puerto Rico, Rio Piedras campus. Facundo Bueso Sanllehí was its first dean. It is located in the city of San Juan, the capital of Puerto Rico. In September 2019, the university won a $US17.4 million research grant from the National Science Foundation, for wearable technology.

The University High School, (Spanish: Escuela Secundaria de la Universidad de Puerto Rico) commonly referred to by its initials "UHS", in San Juan, Puerto Rico is a college preparatory laboratory high school operated by the Faculty of Education of the University of Puerto Rico. Located on the University of Puerto Rico, Río Piedras Campus, it provides education to approximately 514 students from 7th to 12th grade.

The University of Puerto Rico, Río Piedras Campus (Spanish: Universidad de Puerto Rico, Recinto de Río Piedras; UPR-RP, or informally La IUPI) is a public land-grant research university in San Juan, Puerto Rico. It is the largest campus in the University of Puerto Rico system in terms of student population and it was Puerto Rico's first public university campus.The university serves more than 18,000 students, 20% of whom are graduate students, and grants an average of over 3,000 degrees a year. Its academic offerings range from the bachelor to the doctoral level with 70 undergraduate programs and 19 graduate degrees including 71 specializations in the basic disciplines and professional fields. UPR‐RP has consistently granted the largest number of doctorate degrees to Hispanic students under the United States jurisdiction.

The Quadrangle (Spanish: El Cuadrángulo) is the heart and main quadrangle of the University of Puerto Rico, Río Piedras. Together with the Roosevelt Tower (La Torre), it is listed on the National Register of Historic Places as the University of Puerto Rico Tower and The Quadrangle, for its unique history which represents the union between Puerto Rican architecture with the Jeffersonian Neoclassical style often seen in American universities. It is famous for its lines of Puerto Rican royal palm (Roystonea borinquena) or palma real and the architecture of its surrounding buildings.The Quadrangle was designed by Puerto Rican architect Rafael Carmoega. The University of Puerto Rico Theater was first built on its eastern edge in 1939. The Quadrangle is the largest courtyard space in the University of Puerto Rico, Río Piedras campus. It is surrounding by buildings currently used by the University of Puerto Rico Administration and the College of Humanities. Its two most notable landmarks are the University Tower located on the western edge of the quad, and the University of Puerto Rico Theater, also known as the Roosevelt Theater, on its eastern edge. These buildings have an architectural style combining Spanish Revival styles such as Andalusian/Spanish Gothic and Baroque Revival. There is also a Banco Popular branch office and additional auditoriums.

Roosevelt Tower (officially: Franklin Delano Roosevelt Tower, Spanish: Torre Franklin Delano Roosevelt), more popularly known as La Torre, is a 173.54 feet (52.89 m) clock tower located above the main entrance to the Baldorioty de Castro Building in the University of Puerto Rico, Río Piedras Campus. The tower is also referred to as El Faro (The Lighthouse) and it is considered a symbol of the University of Puerto Rico and of higher education in Puerto Rico. The tower, along with the main historic quadrangle in campus, have been listed on the National Register of Historic Places since 1984.

Río Piedras Antiguo is one of the 6 subbarrios of Pueblo, a barrio in San Juan, Puerto Rico. It was, at one time, a subdivision of Río Piedras, a former municipality of Puerto Rico.

The University of Puerto Rico (Spanish: Universidad de Puerto Rico, UPR) is the main public university system in the U.S. Commonwealth of Puerto Rico. It is a government-owned corporation with 11 campuses and approximately 44,200 students and approximately 4,450 faculty members. UPR has the largest and most diverse academic offerings in the commonwealth, with 472 academic programs of which 32 lead to a doctorate.

Río Piedras is a populous district of San Juan, and former town and municipality of Puerto Rico, which was merged with the municipality of San Juan in 1951. The district today is composed of various barrios (these are the primary legal divisions of municipalities in Puerto Rico) such as Pueblo and Universidad. The historic town was founded in 1714 as El Roble, it was given municipality rights in 1823, and since 1903 it has been the home of the University of Puerto Rico's main campus, earning the popular name of Ciudad Universitaria (similar to college town) today. The downtown and historic center of Río Piedras is officially known as the Pueblo barrio of the municipality of San Juan.

Capetillo is a subbarrio, a legal subdivision of Pueblo, a barrio in San Juan, Puerto Rico. It was, at one time, a subdivision of Río Piedras, a former municipality of Puerto Rico.

The Río Piedras Mosque (Spanish: Mezquita de Río Piedras) or Puerto Rico Islamic Center (Spanish: Centro Islámico de Puerto Rico) is a mosque in Río Piedras, San Juan, Puerto Rico.

The Humberto Vidal explosion (sometimes also referred to as the Río Piedras explosion) was a gas explosion that occurred on November 21, 1996 at the Humberto Vidal shoe store in Río Piedras, Puerto Rico. The explosion killed 33 and wounded 69 others when the building collapsed. It is one of the deadliest disasters to have occurred on the island.

Institución is one of the 5 subbarrios of Universidad, itself one of 18 barrios of San Juan, Puerto Rico.