Old Piedras River Aqueduct

The San Juan Botanical Garden, officially known as the Botanical Garden of the University of Puerto Rico, is located in the Caribbean city of San Juan, capital of Puerto Rico. This lush 300-acre (1.2 km2) “urban garden” of native and exotic flora serves as a laboratory for the study, conservation and enrichment of plants, trees, flowers, grasses and many other plants. Seventy-five acres are landscaped and open to the general public as well as researchers. The entrance is located off the south side of the intersection of Highway 1 and Road 847 in Río Piedras. The “Bosque Urbano del Nuevo Milenio” (Nuevo Milenio State Forest), a project for the conservation and growth of the urban forest, is on the eastern side of the Botanical Garden.

El Cinco is one of the 18 barrios of the municipality of San Juan, Puerto Rico and a former barrio of the dissolved municipality of Río Piedras. As of the 2010 United States Census, it had a population of 6,198 and a land area of 1.34 square miles (3.5 km2) resulting in a population density of 4,625.4/sq mi (1,785.9/km2).

Cupey is a rapid transit station in San Juan agglomeration, Puerto Rico. It is located between Centro Médico and Río Piedras stations on the only line of the Tren Urbano system, in the El Cinco district of the city of San Juan. The station is named after the barrio of Cupey, located further south. The trial service ran in 2004, however, the regular service only started on 6 June 2005.

The Río Piedras Bridge (Spanish: Puente de Río Piedras) or Piedras River Bridge (Puente del Río Piedras), also designated as Bridge #3, is a historic 19th-century barrel vault bridge located in the former town of Río Piedras, today part of the city of San Juan, Puerto Rico, that spans across the Piedras River. The bridge was built in 1853 as part of the development of the Carretera Central that linked San Juan to Ponce, making it the oldest still-existing bridge of said route. Today the bridge is still stable and usable, and it can be found near the entrance of the University of Puerto Rico Botanical Garden. It was added to the National Register of Historic Places in 1995 and it is considered to be the best-preserved example of a Spanish masonry arch bridge anywhere in Puerto Rico and the United States.

Venezuela is one of the six subbarrios of Pueblo barrio in the municipality of San Juan in Puerto Rico. It was, at one time, a subdivision of Río Piedras, a former municipality of Puerto Rico.

Santa Rita is one of the 4 subbarrios of Hato Rey Sur, itself one of 18 barrios of the municipality of San Juan, Puerto Rico.The office of Amnesty International in Puerto Rico is located in Santa Rita.

Monte Rey is a subbarrio, a legal subdivision of Pueblo, a barrio in San Juan, Puerto Rico. It was, at one time, a subdivision of Río Piedras, a former municipality of Puerto Rico.

Ubarri is a subbarrio, a legal subdivision of Pueblo, a barrio in San Juan, Puerto Rico. It was, at one time, a subdivision of Río Piedras, a former municipality of Puerto Rico.

The Río Piedras State Penitentiary, also known as Puerto Rico Island Penitentiary or Oso Blanco (or White Bear in English), was a correctional facility located in Río Piedras, Puerto Rico.

Río Piedras Pueblo (officially just Pueblo, unofficially downtown Río Piedras), is one of 18 barrios in the municipality of San Juan, Puerto Rico. Rio Piedras Pueblo is what used to be the urban center-barrio (downtown district) of the former municipality of Río Piedras until 1951, when the municipality of Rio Piedras was merged with the municipality of San Juan. Rio Piedras Pueblo is bounded to the west by Hato Rey Sur and El Cinco, with Universidad barrio to the North, and with Sabana Llana Sur barrio to the south and east. It is made up of 6 subbarrios: Buen Consejo, Capetillo, Monte Rey, Río Piedras Antiguo, Ubarri, and Venezuela. The University of Puerto Rico, Rio Piedras is located nearby.

Loverbar was a queer bar, restaurant and nightclub located in Río Piedras, San Juan, Puerto Rico. As a queer club it was the first of its kind in Puerto Rico, with Refinery29 calling it "the queer destination for everything exciting, progressive, and radical about the Puerto Rican queer scene." It opened in 2020 and announced its closure at the end of 2021.

Río Piedras is a rapid transit station in the San Juan Metropolitan Area, Puerto Rico. It is located between Cupey and Universidad stations on the only line of the Tren Urbano system, in the downtown area of Río Piedras (Río Piedras Pueblo), in the city of San Juan. The station is named after Río Piedras where it is located, itself named after the Piedras River which crosses the area. The trial service ran in 2004, however, the regular service only started on 6 June 2005.