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Pearl Street is a street in the Financial District in Lower Manhattan, running northeast from Battery Park to the Brooklyn Bridge with an interruption at Fulton Street, where Pearl Street's alignment west of Fulton Street shifts one block south of its alignment east of Fulton Street, then turning west and terminating at Centre Street.

The Hague Street explosion occurred on February 4, 1850, in New York City, when a boiler exploded at a printing press manufacturer. The blast killed at least 67 people, injured around 30, and sent thousands running into the streets. According to news reports at the time, the head of the boiler was carried up through all six of the building's stories and finally tore off the building's roof, while the building itself lifted six to seven feet (1.8 to 2.1 m) in the air, causing it to collapse in on itself. One report stated, The windows and doors across Hague Street, and in the rear of houses [on] Pearl Street, were burst in as if with cannon shot, and everything around indicates that the explosion was one of the most violent that could occur. So powerful was the explosion that the shock, like the trembling of an earthquake, was felt in some of the stores [on] Broadway, a distance, in a direct line, of about a quarter of a mile, and was probably felt at a greater distance. The rescue effort was led by New York City Mayor Caleb Smith Woodhull and the New York City Police Department, with assistance from the fire department. About 100 rescuers were divided into three teams, working in shifts. The last person to be rescued was a young boy who had been trapped for 17 hours under a mass of wood and iron beams. The boy died of burn injuries shortly after his rescue; his story featured prominently in newspaper reports of the day.

70 Pine Street – formerly known as the 60 Wall Tower, Cities Service Building, and American International Building – is a 67-story, 952-foot (290 m) residential building in the Financial District of Lower Manhattan in New York City. It was designed by the firm of Clinton & Russell, Holton & George in the Art Deco style. 70 Pine Street, built in 1930–1932 by energy conglomerate Cities Service Company (later Citgo), was Lower Manhattan's tallest building and the world's third-tallest structure upon its completion. 70 Pine Street occupies a trapezoidal lot on Pearl Street between Pine and Cedar Streets. It features a brick, limestone, and gneiss facade with numerous setbacks. The building contains an extensive program of ornamentation, including the Cities Service Company's triangular logo and solar motifs. The interior features included escalators at the base and double-deck elevators linking the tower's floors. A three-story penthouse, intended for Cities Service's founder Henry Latham Doherty, was later utilized as a public observatory. 70 Pine Street's construction was funded through a public offering of stock, rather than a mortgage loan. Despite having been built during the Great Depression, the building was profitable enough that it broke even by 1936, with 90% of the space occupied five years later. The American International Group (AIG) bought the building in 1976, and it was acquired by another firm in 2009 after AIG went into bankruptcy. The building and its first floor interior were designated as official New York City landmarks in June 2011. In 2016, the building became a luxury rental residential property.

90–94 Maiden Lane is a cast-iron building on Gold Street between William and Pearl Streets in the Financial District of Manhattan, New York City. It was built in 1870-71 in the French Second Empire style and is attributed to Charles Wright. It has a cast-iron facade from Daniel D. Badger's Architectural Iron Works, and is one of the few surviving examples of cast-iron architecture between Fulton Street and the Battery, as well as one of a few mid-19th century commercial buildings extant in Lower Manhattan. The building's facade was commissioned by Roosevelt & Son, the leading plate glass and mirror importer. Theodore Roosevelt Sr., father of U.S. President Theodore Roosevelt, was one of the company's principals. Unlike most other buildings of its sort, it has not been converted into condominium apartments, and is still in use as a commercial building.The building was designated a New York City landmark on August 1, 1989.

116 John Street is a historic office tower at the southwest corner of John Street and Pearl Street in the Financial District of Lower Manhattan in New York City. It was built in 1931, and is a 35-story brick and terra cotta building consisting of a three-story base, a 19-story shaft, and 12 upper stories that recede in a series of setbacks. The building features Art Deco style design elements at the recessed entrances and in the lobby. Built as a speculative office building for insurance companies, the building interior was rehabilitated in 2013 and some floors converted to apartments.: 3–4, 7 It was listed on the National Register of Historic Places in 2014.

161 Water Street (also referred to as the Water Street Associates Building and formerly referred to as 175 Water Street) is an office building in the Financial District of Manhattan in New York City.

Crown Shy is a restaurant in New York City, New York. The restaurant serves American cuisine and has received a Michelin star.

Saga is a restaurant in New York City. The restaurant has received two Michelin stars. Time Out New York has rated Saga 4 out of 5 stars.

120 Wall Street is a skyscraper in the Financial District of Lower Manhattan in New York City. It was completed in 1930. The building is 399 ft (122 m) tall, has 34 floors, and is located on the easternmost portion of Wall Street, and also borders Pine Street and South Street. The architect was Ely Jacques Kahn of Buchman & Kahn.The tower is tiered on three sides, forming the classic wedding-cake style outline emblematic of post-1916 Zoning Resolution New York skyscrapers. The setbacks recede in shallow formations from a large 16-story platform. Red-granite panels frame wide-paned commercial windows at street level as part of the five-story limestone base.The building has 615,000 square feet (57,100 m2) of space and occupies a 23,000-square-foot (2,100 m2) lot.

The Thurgood Marshall College Fund (TMCF) is an American non-profit organization that supports and represents nearly 300,000 students attending its 47 member-schools that include public historically black colleges and universities (HBCUs), medical schools, and law schools. The organization is named after the Supreme Court's first African-American Justice, Thurgood Marshall.

amfAR, the Foundation for AIDS Research, known until 2005 as the American Foundation for AIDS Research, is an international nonprofit organization dedicated to the support of AIDS research, HIV prevention, treatment education, and the advocacy of AIDS-related public policy. AmfAR is a tax-exempt corporation under Internal Revenue Code section 501(c)(3) and operates as an independent nonprofit with worldwide initiatives. amfAR was formed in New York City in September 1985 by Dr. Mathilde Krim, along with physician Dr. Joseph Sonnabend and activist Michael Callen. The organization originally began in April 1983 as the Krim-founded AIDS Medical Foundation (AMF), which sought to lessen the stigma surrounding HIV/AIDS diagnoses, as well as to increase funding to the cause. The name change came as a result of the AMF's merge with the California-based National AIDS Research Foundation, which sought to actively engage in HIV-related drug development. What resulted was a foundation that prioritized both research and development as well as policy influence. This foundation was one of the first of its kind to embody both aspects of healthcare. AmfAR currently has three headquarters, located in New York City; Washington, D.C.; and Bangkok, Thailand. AmfAR spurs research and development through providing grants and fellowships to organizations, such as the Family Institute of Health, and individuals through the Mathilde Krim Fellowships in Basic Biomedical Research. AmfAR has provided over 3,300 grants to research teams across the world and has invested over $400 million to research aiming to effectively treat HIV and AIDS related illness. AmfAR's funds historically have gone to funding research, and as a result have helped pioneer community-based clinical research trials in the 1980s, as well as the involvement of AIDS patients in the drug approval process (see also: Denver Principles). Changes in leadership have marked changes in focus, resulting in shifts from public health outreach (needle exchange program pushes) to public education (the amfAR AIDS Handbook) to international research and outreach.AmfAR has embarked on various national and international campaigns to spur AIDS/HIV research, create a dialogue and decrease stigma surrounding the disease. Through TREAT Asia and GMT, amfAR took international roots and began funding research and outreach on all inhabited continents. National initiatives have included the Countdown to a Cure for AIDS. The Institute for HIV Cures Research and amfAR Research Consortium on HIV Eradication (ARCHE) were both created to aid this countdown, both to help fund research as well as provide a facility at which those researcher can work. To supplement the funding of these initiatives, amfAR is funded through sources like stock donations and their annual galas, which represent the majority of their source of funding.After Kenneth Cole stepped down as chairman, he was replaced by William H. Roedy. The current CEO Kevin Robert Frost joined amfAR in 1994 and became CEO in 2004. Together they lead 9 members of the Management Team, 25 Board of Trustees members and over 100 advisors to both their scientific and political platforms.Charity Watch rates the Foundation for AIDS Research an "A-" grade.Charity Navigator rates amfAR a four-star charity.

The Continental Center is an office skyscraper located in the Financial District of Manhattan, New York City.Built in 1983, in the construction of Swanke Hayden Connell Architects, the building is 41 stories tall and reaches a height of 169 metres (554 ft).