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California Coast University (CCU) is a private for-profit online university based in Santa Ana, California. It is accredited by the Distance Education Accrediting Commission and approved by the State of California. Approximately 8,000 students are enrolled at any given time.

The Discovery Cube Orange County, formerly known as the Discovery Science Center and the Taco Bell Discovery Science Center, is a science museum in Santa Ana, California, with more than 100 hands-on science exhibits designed to spark children's natural curiosity. Designed by the architect firm Arquitectonica with structural engineers Carl Johnson and Svend Nielsen, it has become a visual landmark due to its ten-story solar array cube that stands over Interstate 5.

Children's Health of Orange County or CHOC is a pediatric healthcare system based in Orange County, California, is committed to being a leading destination for children’s health by providing exceptional and innovative care. Its flagship hospital, known by its acronym CHOC Hospital, is a pediatric acute care hospital located in Orange, California. The hospital has 334 beds and is affiliated with the University of California, Irvine School of Medicine. The hospital provides comprehensive pediatric specialties and subspecialties to pediatric patients aged 0–21 throughout Orange County and the Southern California area. CHOC Hospital also features a Level I Pediatric Trauma Center, the only of such in Orange County. The regional pediatric healthcare network includes a 334-bed main hospital facility in the City of Orange, and a hospital-within-a-hospital in Mission Viejo. CHOC also offers many primary and specialty care clinics, over 100 additional programs and services, and a pediatric residency program.

The Rancho Santiago Community College District (RSCCD), one of four community college districts located in Orange County, California, offers associate degrees and adult education certificates through its two colleges: Santa Ana College in Santa Ana and Santiago Canyon College in Orange. The RSCCD serves central and eastern Orange County, covering 24% of the county's total area (193 square miles) in the cities of Orange and Villa Park, as well as the community of Anaheim Hills and portions of the cities of Garden Grove, Irvine, Santa Ana, and Tustin. The RSCCD is governed by a Board of Trustees that is composed of seven trustees elected by the registered voters within the district's boundaries and one student member elected by the student body of Santa Ana College and Santiagao Canyon College. Trustees, with the exception of the student member, are elected to four-year terms commencing in December of the year elected. As terms are staggered, elections are held every two years in connection with the general election. The seven locally elected trustees must reside in three specific areas but are elected at-large. The current trustees and the areas that they were elected from are as follows: For 2020, Trustee Claudia C. Alvarez is serving as the Board President, Trustee Nelida Mendoza as the Board Vice President, and Trustee Phillip Yarbrough as the Board Clerk.

The Orange Crush interchange, frequently called The Crush, is a freeway interchange in the city of Orange, California, near the borders of the cities of Orange, Santa Ana, Anaheim, and Garden Grove. The Disneyland Resort, The Outlets at Orange, St. Joseph Hospital, Children's Hospital of Orange County, the UCI Medical Center, Westfield MainPlace, Angel Stadium of Anaheim, Honda Center, Platinum Triangle and the Lamaroux Justice Center of the Superior Court of California of the County of Orange are all located at or near the interchange.This interchange of the Santa Ana (Interstate 5), Garden Grove (State Route 22), and Orange (State Route 57) freeways was listed in the 2002 Guinness World Records book as the most complex road interchange in the world. The name of the interchange, credited to KNX Radio traffic and weather reporter Bill Keene, is a play on the name of the Orange Crush soda.

CNI College (also Career Networks Institute) is an allied health vocational college in Santa Ana, California. The main campus is located in the City of Orange.

The Bowers Museum is an art museum located in Santa Ana, California. The museum's permanent collection includes more than 100,000 objects, and features notable strengths in the areas of pre-Columbian Mesoamerica, Native American art, the art of Asia, Africa, and Oceania, and California plein-air painting. The Bowers organizes and hosts special exhibitions from institutions throughout the world, and travels exhibitions nationally and internationally. The museum has a second campus two blocks south of the main site, Kidseum, a children's museum with a focus on art and archaeology. The Bowers Museum and Kidseum are located in Santa Ana 6.4 km (four miles) south of Disneyland.

South Coast College is a private for-profit technical college in Orange, California. It offers certificates for career preparation in court reporting and medical assistant careers and a paralegal Associate of Arts degree. It is accredited by the Accrediting Commission of Career Schools and Colleges and approved by the Bureau for Private Postsecondary Education in the state of California, for court reporting, paralegal, and medical assistant programs.

Holy Family Catholic Church, located in Orange, California, United States, is a parish church in the Diocese of Orange. It served as the cathedral of that diocese, from the diocese's establishment in 1976, until Christ Cathedral in Garden Grove, California, the former Crystal Cathedral, was dedicated on July 17, 2019. Because of this, Holy Family Cathedral changed its name to Holy Family Catholic Church. Holy Family Parish predates the establishment of the Diocese of Orange.

Orange station, formally the Orange Transportation Center is an intermodal transit station in Orange, California. It serves Metrolink trains as well as Orange County Transportation Authority buses. The station is located at the site of two former Atchison, Topeka and Santa Fe Railway combination depots. The present depot structure was dedicated on May 1, 1938 and was closed with the Santa Fe's discontinuation of passenger service in 1971. The building was granted historic landmark status by the City on November 15, 1990.

Santa Ana Fire Station Headquarters No. 1, at 1322 N. Sycamore St. in Santa Ana, California, is a fire station which was built in 1929. It was listed on the National Register of Historic Places in 1986.It was designed by Santa Ana architect Frederick Eley. It is a two-story Spanish Colonial Revival-style, stuccoed building.

Fountain Family Group, sometimes called Nuclear Family, is a 1969 bronze sculpture and fountain by Richard H. Ellis, formerly installed along Wilshire Boulevard in Santa Monica, California.