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The Otay Mesa East Port of Entry is a planned border crossing between San Diego and Tijuana, approximately 2 miles east of the existing Otay Mesa Port of Entry. The crossing will connect the Otay Centenario borough of Tijuana with East Otay Mesa in unincorporated San Diego County, an as-yet undeveloped area slotted for future development including a business park. Although the crossing will allow cars and pedestrians, it is mainly designed for trucks and commercial vehicles. In July 2014, Mexican Undersecretary of Infrastructure of the Secretariat of Communications and Transportation Raúl Murrieta Cummings and the Secretary of the California Department of Transportation (Caltrans), Brian P. Kelly, signed a memorandum of understanding to build and put the new port of entry into operation. It was expected to be ready as early as 2017, and provide 27 northbound lanes from Tijuana to San Diego and 8 southbound lanes. The cost is estimated to be 2 billion Mexican pesos (about 99 million US dollars).Construction began at the initial ground breaking in August 2022, after long delays. Although earlier estimates suggested the project would be completed by late 2024, more recent estimates suggest construction may not be complete until 2026.

East Otay Mesa is an as-yet undeveloped area in the South Bay region of unincorporated San Diego County, southern California. It is located along the northern side of the U.S.-Mexico border, with plans for future developments, including a border crossing and business park. East Otay Mesa is immediately east of the Otay Mesa neighborhood of the city of San Diego, west of the San Ysidro Mountains, and north of the Centenario borough of Tijuana, Mexico. The Otay Mesa East Port of Entry (also "Otay Mesa II"), a new planned border crossing, is to connect East Otay Mesa with Centenario, Tijuana, starting in 2023.

The San Diego Correctional Facility, also known as the Otay Mesa Detention Facility, is a minimum / medium security federal prison for men, managed by Corrections Corporation of America under contract with the United States Marshals Service and U.S. Immigration and Customs Enforcement (ICE).The facility is situated in the San Ysidro Mountains foothills of Otay Mesa overlooking the U.S.-Mexico border. The Otay Mesa site is shared with four other properties related to law enforcement: Richard J. Donovan Correctional Facility, operated by the California Department of Corrections and Rehabilitation. George Bailey County Detention facility, operated by the County of San Diego East Mesa Reentry Facility, operated by the City of San Diego Multi-jurisdictional law enforcement firearms training complex used by the FBI, the Customs Service, and local police forces.

Richard J. Donovan Correctional Facility (RJDCF or RJD) is a California state prison located in unincorporated southern San Diego County, California, near San Diego. It is a part of the California Department of Corrections and Rehabilitation. It is a 780-acre (320 ha) facility. It is the only state prison in San Diego County. The prison is situated on a mesa about 1.5 miles (2.4 km) from the Mexico–United States border, in the foothills of Otay Mesa overlooking the border. The Otay Mesa site is shared with six other properties related to law enforcement: the federal San Diego Correctional Facility privately operated by the Corrections Corporation of America the George Bailey Detention Facility (San Diego County) the East Mesa Reentry Facility (San Diego County) the Facility 8 Detention Facility (San Diego County) the East Mesa Juvenile Detention Facility (San Diego County) and a multi-jurisdictional law enforcement firearms training complex used by the FBI, the Customs Service, and local police forces

The Otay Mesa Port of Entry (Spanish: Puerto de Entrada Mesa de Otay) is one of three ports of entry (POE) in the San Diego–Tijuana metropolitan region, in the U.S. state of California, connecting Otay Mesa in the City of San Diego with the Otay Centenario borough of Tijuana. The facility was opened in 1983, and was constructed primarily to divert growing commercial truck traffic from the busy San Ysidro Port of Entry, located 5.2 miles (8.4 km) west. Since then, significant passenger vehicle and pedestrian traffic has grown as development in the area around the crossing has grown. Commercial importations through Otay Mesa accounts for billions of dollars' worth of freight.The Otay Mesa Port of Entry is accessed by California State Route 905 on the northern side. Since commercial traffic cannot use the San Ysidro Port of Entry, for commercial traffic Otay Mesa is the southern terminus of the Interstate 5 corridor. The port of entry is the third-busiest commercial port of entry on the Mexico–United States border. To reduce wait times a facility built by the Mexican federal government, staffed by United States Customs and Border Protection officers and Mexican customs officers, will be opened on the Mexican side of the border. It will be used to screen produce, which are considered low-risk commodities. A similar facility will be located at the Laredo International Airport, where Mexican customs officers will pre-inspect air shipments into Mexico.

The Otay River () is a river in southern San Diego County, California. The 25 mi (40 km) river begins at San Miguel Mountain, flows through the Upper and Lower Otay Reservoirs, and continues on between the southern part of the Chula Vista and the Otay Mesa West district of San Diego, to its river mouth on San Diego Bay.

Savage Dam is a dam across the Otay River in the San Ysidro Mountains of southwestern San Diego County, California. It is a concrete arch gravity structure 149 feet (45 m) high, and serves to store water from the San Diego Aqueduct's third pipeline for backup municipal uses in the San Diego metropolitan area. It is just over 6 miles (9.7 km) southeast of Chula Vista and 4 miles (6.4 km) north of the United States-Mexico border. The dam is named in honor of H. N. Savage, who directed its construction.The dam was originally completed in 1897 as an earthfill and steel structure called the Otay Dam by the Southern California Mountain Water Company to provide water storage. However, in 1916, heavy rains supposedly brought on by Charles Hatfield, a "rainmaker", hired by the city of San Diego to put an end to a drought, caused the dam to burst. The failure sent a wall of water 40 feet (12 m) high downstream, destroying buildings and bridges, and washing thousands of tons of sediment and wreckage into San Diego Bay. Eleven Japanese American farmers were killed. The dam was rebuilt as Savage Dam in 1918, and has functioned properly since.

Otay Centenario is a borough of the municipality of Tijuana in Baja California, Mexico. It is the result of a merger between the former boroughs of Mesa de Otay and Centenario which took place on January 1, 2014.The borough is located east of the Centro borough and the Zona Río; south of the U.S. border and San Diego's Otay Mesa neighborhood; and north of La Mesa. Tijuana International Airport, and many maquiladoras are located here. Main shopping centers are the Centro Comercial Otay and Plaza Americana Otay, which is located in front of Centro Comercial Otay. The area is noted as the second gastronomic hub of the city, with many restaurants. The former Centenario borough has the largest number of factories and maquiladoras in the city. Its largest neighborhood (colonia) is Ciudad Industrial ("Industrial City"). Three of the city's most important streets, Boulevard Bellas Artes, Boulevard Industrial and Mexican Federal Highway 2, are located here. Parque de la Amistad (not to be confused with Friendship Park at the border in Playas de Tijuana) is a large park in the borough.

Rancho Janal was a 4,437-acre (17.96 km2) Mexican land grant in present day San Diego County, California given in 1829 by Governor José María de Echeandía to José Antonio Estudillo. The grant was located near present day Otay Mesa. A large portion of the grant is now covered by the waters of the Upper and Lower Otay Reservoirs. Rancho Janal and the adjoining Rancho Otay were granted to members of the Estudillo family, and they are often considered as one rancho.

High Tech High Chula Vista is a charter school in Chula Vista, California. The high school, being open-campus and project-based, opened in the fall of 2007 with approximately 150 9th-grade students. Students are admitted into the school through a randomized lottery acceptance system to bring diversity. High Tech High Chula Vista has an internship program engrained into the junior-year curriculum. Junior students spend four weeks interning for a professional organization of their choice and need thirty hours a week. The students have a designated mentor in their organization who communicates with and supports them in their work. Juniors must complete a relevant project while in their internship that benefits the organization and is later presented to teachers, families, and mentors.