Iglesia de San Antonio de Padua

Casa Cautiño is a house museum in Guayama, Puerto Rico. The museum collection, administered by the Institute of Puerto Rican Culture, include works of art, wood carvings, sculptures and furniture built by Puerto Rican cabinetmakers for the Cautiño family. It is listed on the National Register of Historic Places.

The Eleuterio Derkes Grammar School (Spanish: Escuela Derkes) is a historic school building in Guayama, Puerto Rico. It was built in 1908, during a period when schools were gaining importance as civic institutions in Puerto Rico. Its simplified Neoclassical design emphasized this shift, and it became a prototype for a generation of school construction on the island. It additionally signifies a transition in construction technologies from wood to concrete. In 1987, architect Jorge Rigau observed that the building had survived in a nearly unaltered state, a rarity among schools of its era.It was inscribed on the National Register of Historic Places in 1987.

The Ingenio Azucarero Vives (English: Vives Sugar Plant), also known as Hacienda Vives, is a historic sugar mill complex with ruins of windmill and a processing building, in Barrio Machete of Guayama, in southern Puerto Rico. Sugarcane was ground by the windmill and the extracted juice was further processed in the processing building, by slaves. A slave uprising occurred here in the early 1800s.It was listed on the National Register of Historic Places in 1976.It is believed to have been constructed by 1828.In 1976, the site was found to be significant as the only example of early industrial architecture and the only windmill in Puerto Rico.It was documented by the Historic American Engineering Record program, with photographs by Jack Boucher. Modern photographs show that the complex has been restored.

Guayama barrio-pueblo is a barrio and the administrative center (seat) of Guayama, a municipality of Puerto Rico. Its population in 2010 was 16,891. As was customary in Spain, in Puerto Rico, the municipality has a barrio called pueblo which contains a central plaza, the municipal buildings (city hall), and a Catholic church. Fiestas patronales (patron saint festivals) are held in the central plaza every year.

Guayama (Spanish: [ɡwaˈʝama], locally [waˈʝama]), officially the Autonomous Municipality of Guayama (Spanish: Municipio Autónomo de Guayama), is a city and municipality on the Caribbean coast of Puerto Rico. As of the 2020 U.S. Census, the city had a population of 36,614. It is the center of the Guayama metropolitan area with a population of 68,442 in 2020.

Guayama Convention Center is a convention center in Guayama, Puerto Rico. It is one of the main performing arts and sports venues in Puerto Rico, especially in the south and southeast areas of the island. The center was built in 2000 and has a capacity of 2700.

The Cayey Bridge, also known as Puente de Cayey, is an iron lateral lattice girder bridge in Puerto Rico that was built in 1891. It brings Puerto Rico Highway 15 over the Guamaní River. It is an extremely rare example of such a bridge in the United States or its territories. Puerto Rico has the only bridges in the United States or its territories built with this technology.The bridge was fabricated by the Belgian firm Nicrisse & Decluve. The girder bridge has two independent spans.It was listed on the National Register of Historic Places in 1995.

Caimital is a barrio in the municipality of Guayama, Puerto Rico. Its population in 2010 was 4,124.

Algarrobo is a barrio in the municipality of Guayama, Puerto Rico. Its population in 2010 was 6,959.

Machete is a barrio in the municipality of Guayama, Puerto Rico. Its population in 2010 was 3,846.

Palmas is a barrio in the municipality of Guayama, Puerto Rico. Its population in 2010 was 709.

Guásimas is a barrio in the municipality of Arroyo, Puerto Rico. Its population in 2010 was 4,030.