Northeast Gainesville Residential District

The Thomas Center, formerly known as Hotel Thomas and Sunkist Villa, is an historic building in Gainesville, Florida, United States. It was built starting in 1910 in the Classical Revival style by noted Atlanta-based architect, William Augustus Edwards, designer of academic buildings at 12 institutions in Georgia, South Carolina and Florida, including the original University of Florida campus, as well as a dozen or more county courthouses in those states plus other building and houses,The building began as the private home of William Reuben Thomas, his wife Kathryn, and their five children, when it was known as Sunkist Villa. In 1928 Thomas more than doubled the size of the home and converted it to a hotel. On July 16, 1973, the building was added to the U.S. National Register of Historic Places. The Thomas Center celebrated its 100th anniversary on February 12, 2010.

The Mary Phifer McKenzie House, now the Sweetwater Branch Inn Bed and Breakfast, is an historic house located at 617 East University Avenue in Gainesville, Florida. It was added to the National Register of Historic Places in 1982.The house was constructed in about 1895 and is an irregularly massed two-and-a-half-story Queen Anne-style home.It is known as one of the most elaborate Victorian buildings ever constructed in Gainesville. It has intricate Eastlake architecture details and a fanciful restored massing. It has three-story octagonal turrets on the west face, a wrap-around veranda, and octagonal gazebo. The Sweetwater Inn includes two restored Victorian-era mansions (the McKenzie House and the Cushman-Colson House.

The 1867 Matheson House is a historic building in Gainesville, Florida, United States. It is located at 528 Southeast 1st Avenue. It was the home of James Douglas Matheson and Augusta Florida Steele Matheson, the daughter of Florida pioneer Augustus Steele, who founded Hillsborough County and Cedar Key. James Douglas Matheson owned a dry goods store in downtown Gainesville and was active in local and state politics, as was his son, eight-term Gainesville mayor Chris Matheson, who was also a state legislator.Chris's widow, Sarah Matheson, deeded the house to the Alachua County Historical Society, which later merged with the Matheson History Museum after it opened in 1994. Sarah Matheson lived in the house until her death in 1996. She was the first female elder at First Presbyterian Church in downtown Gainesville and was an early president of the Alachua County Historical Society and a co-founder and member of the original board of directors of the Matheson Histical Center (now the Matheson History Museum). The 1867 Matheson House is now part of the Matheson History Museum Complex, which recounts the history of Alachua County. On June 4, 1973, it was added to the U.S. National Register of Historic Places. The house is open by appointment only.

Gainesville Masonic Lodge No. 41 in Gainesville, Florida is a historic Masonic building, located at 215 North Main Street. It was constructed by Gainesville Masonic Lodge No. 41 in 1908. On May 29, 1998, it was added to the U.S. National Register of Historic Places.

Gainesville is the county seat of Alachua County, Florida, and the most populous city in North Central Florida, with a population of 145,214 in 2022. It is the principal city of the Gainesville metropolitan area, which had a population of 339,247 in 2020.Gainesville is home to the University of Florida, the fourth-largest public university campus by enrollment in the United States as of the 2021–2022 academic year. The university is represented by the Florida Gators sports teams in NCAA competitions.

The Battle of Gainesville was an American Civil War engagement fought on August 17, 1864, when a Confederate force defeated Union detachments from Jacksonville, Florida. The result of the battle was the Confederate occupation of Gainesville for the remainder of the war.

The Star Garage (also known as the Crawford and Davis Livery Stable or Poole-Gable Motors) is a U.S. historic building in Gainesville, Florida. It is located at 119 Southeast 1st Avenue. On December 17, 1985, it was added to the U.S. National Register of Historic Places.

The Cox Furniture Store (also known as the Simonson Opera House or Edwards Opera House or New Baird Theater) c. 1890 is a historic site in Gainesville, Florida, United States. Built in the form and style of a small Romanesque Revival church, it is located at 19 Southeast First Avenue. On June 10, 1994, it was added to the U.S. National Register of Historic Places.

The Southeast Gainesville Residential District is a U.S. historic district (designated as such on January 14, 1988) located in Gainesville, Florida. It encompasses approximately 335 acres (1.36 km2), bounded by East University Avenue, Southeast Ninth Street, Southeast Fifth Avenue, and Sweetwater Branch. It contains 94 historic buildings.

The Hippodrome Theatre (locally known as The Hippodrome or The Hipp) is a regional professional theatre in downtown Gainesville, Florida, United States. It was founded in 1973 by local actors and was added to the U.S. National Register of Historic Places on July 10, 1979.

The Pleasant Street Historic District in Gainesville, Florida is a U.S. historic district (designated as such on April 20, 1989) located in Gainesville, Florida. It encompasses approximately 770 acres (3.1 km2), bounded by Northwest 8th Avenue, Northwest 1st Street, Northwest 2nd Avenue, and Northwest 6th Street. It contains 259 historic buildings.

The historic Firestone Building in downtown Gainesville, Florida is located on West University Avenue (SR 26) at the intersection on NW 3rd Street.