St. Elizabeth Hospital (Appleton, Wisconsin)

The Vulcan Street Plant was the first Edison hydroelectric central station. The plant was built on the Fox River in Appleton, Wisconsin, and put into operation on September 30, 1882. According to the American Society of Mechanical Engineers, the Vulcan Street plant is considered to be "the first hydro-electric central station to serve a system of private and commercial customers in North America". It is a National Historic Mechanical Engineering Landmark, an IEEE milestone and a National Historic Civil Engineering Landmark.The Vulcan Street Plant was housed in the Appleton Paper and Pulp Company building, which burned to the ground in 1891. A replica of the Vulcan Street Plant was later built on South Oneida Street.

The Fox River Paper Company Historic District, now known as the Historic Fox River Mills, is a complex of paper mill buildings in Appleton, Wisconsin, United States, built from 1883 to 1915. The historic district includes the Romanesque-styled Ravine/Rag Mills, the Italianate-styled Lincoln Mill which originally milled flour, and the Italianate-styled Fox River Mill. The site is now used as apartments but also retains a functioning hydroelectric canal and privately owned generating station. This hydroelectric infrastructure continues a tradition of electricity from water power dating from the 1880s which makes the Lower Fox River the oldest hydroelectric generation region in the United States.

The Atlas Science Center, formerly Paper Discovery Center, is a museum and workshop center focused on papermaking in Appleton, Wisconsin, United States, where paper is an important local industry. Programs in the past have included hands-on work experience, tours, and general information on papermaking. There is a Science Summer Series for children at the center.The Paper Discovery Center opened in February 2005. It was first conceived in 1999 as part of the Paper Industry International Hall of Fame, Inc. The Kimberly-Clark Corporation donated its former Atlas Mill on the Fox River in Appleton to house the center.

The John Hart Whorton House is located in Appleton, Wisconsin, United States. It was added to the National Register of Historic Places in 1974.

Main Hall is an academic building on the campus of Lawrence University in Appleton, Wisconsin. Constructed in 1853, it was listed on the National Register of Historic Places in 1974.Main Hall was the second building on the Lawrence campus, after the long-demolished Lawrence Institute building erected in 1848. Funding for the building came from the sale of $100 "perpetual scholarships" to Lawrence College. It is constructed of stone from local limestone quarries, with a dome made from wood and hand-hewed beams from local sawmills. When it was first built, Main Hall housed a library, chapel, classrooms, housing for men, and offices for faculty and administration. The building was known in the early twentieth century as "Recitation Hall." It was remodeled in 1938, 1941, the 1970s, and 1999. A sundial from Milwaukee-Downer College was added to the back of the building after that institution merged with Lawrence in 1964. As of 2010, it held classrooms and offices for classics, languages, history, philosophy, and religious studies departments, as well as a student commons and a faculty lounge.

Lawrence University is a private liberal arts college and conservatory of music in Appleton, Wisconsin. Founded in 1847, its first classes were held on November 12, 1849. Lawrence was the second college in the U.S. to be founded as a coeducational institution.

All Saints Episcopal Church is a historic Episcopal church in Appleton, Wisconsin. A parish in the Diocese of Fond du Lac, it is the only Episcopal church in Appleton. The congregation first met circa 1854 and organized in 1856. The current church building was consecrated in 1905.

The College Avenue Historic District in Appleton, Wisconsin is a 7-acre (2.8 ha) historic district that was listed on the National Register of Historic Places in 1982. In 1982, it included 27 buildings deemed to contribute to the historic character of the area, one of which is the 12 story Zuelke Building, and one contributing object, the Soldiers Square Civil War Monument.The contributing buildings include: Zuelke Building, 103 W. College Avenue, a twelve-story gray granite building. Its interior is one of few intact original interiorsin the district. Gibson's Auto Exchange, at 211 W. College Avenue, Art Deco. Bissing Building, 203-205 W. College Avenue, with lions' heads in its roofline pediments. In 1982 two commercial establishments, Boot Hill and Brown Beam Tavern, occupied the building.

The History Museum at the Castle is a local history museum located in downtown Appleton, Wisconsin across College Avenue from Lawrence University. Owned and operated by the Outagamie County Historical Society (OCHS), the museum has previously operated under the names The Outagamie Museum and The Houdini Historic Center. The building was earlier known as Masonic Temple. In 2018 the museum was a recipient of the 2018 National Medal for Museum and Library Service, the highest honor given to a museum or library in the United States.

The Fox Cities Exhibition Center is a multi-purpose convention center located in the city of Appleton, Wisconsin in the United States. The city of Appleton owns the center and is operated by the connected Hilton Appleton Paper Valley Hotel. On September 29, 2016, ground was broken on the Fox Cities Exhibition Center. It was finished and inaugurated on January 11, 2018, for an estimated cost of $31.9 million. Funding for the construction of the center is being provided by a 3% hotel-room tax being charged throughout the Fox Cities region. It was designed by Zimmerman Architectural Studios and Miron Construction served as the general contractor.The center is primarily used for conventions, meetings, trade shows, and community events. The Center welcomed over 60 events upon its first year open, which bypassed the expected events goal, with many more events planned for the future.

The Hearthstone Historic House Museum is a historic home in Appleton, Wisconsin, United States that has been converted into a museum. On September 30, 1882, it became the first residence in the US powered by a centrally located hydroelectric station using the Edison system. At that time, the house was the residence of Henry James Rogers, a paper company executive and entrepreneur. It was listed on the National Register of Historic Places on December 2, 1974. The house was previously known as the Henry J. Rogers House.

Valley New School (VNS) is a charter school in Appleton, Wisconsin operated by the Appleton Area School District. It has a capacity of 68 students in grades 7 through 12. The school operates through a project-based learning model, with the philosophy that 21st century skills and the process of learning is more important than learning a standard curriculum.