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Rutgers Houses, also known as Henry Rutgers Houses, is a public housing development built and maintained by the New York City Housing Authority (NYCHA) on the Lower East Side of Manhattan. Rutgers Houses is composed of five 20 story buildings on 5.22 acres (21,100 m2), with 721 apartments housing approximately 1,675 people. The complex is bordered by Madison Street to the north, Rutgers Street to the east, Cherry Street to the south, and Pike Street to the west.

Cherry Street is a one-way street in the New York City borough of Manhattan. It currently has two sections, mostly running along parks, public housing, co-op buildings, tenements, and crossing underneath the Manhattan Bridge.

One Manhattan Square (also known as 225 Cherry Street or 252 South Street) is a residential skyscraper project developed by Extell Development Company in the Two Bridges neighborhood of Manhattan, New York City. Built from 2014 to 2019, the project was built on the site of a former Pathmark grocery store, which was demolished in 2014. The building topped out in 2017 and stands out significantly within the context of the neighborhood, at 847 feet (258 m) in height, the next highest structure being the Manhattan Bridge at roughly 336 feet (102 m) in height. A 13-story affordable housing component will be located separately on-site from the main tower. The building topped out in September 2017 and was complete by August 2019.

Henry Street is a street in the Lower East Side of the New York City borough of Manhattan that runs one-way eastbound, except for two small two-way segments west of Pike Street and east of Montgomery Street. It spans from Oliver Street in the west (locally called "south" because it is towards downtown), passing underneath the Manhattan Bridge and on to Grand Street in the east ("north"). The street is named for Henry Rutgers, a hero of the American Revolutionary War and prominent philanthropist. Rutgers Street, which intersects with Henry Street, is also named for him.Thanks to Rutgers' generosity a church was constructed at Henry and Oliver Streets to serve sailors from the East River docks. The Mariner's Temple at 3 Henry Street was built in 1845, and continued to serve maritime workers and their families. It is a New York City Landmark, and was added to the National Register of Historic Places in 1980. The poor condition of immigrants living in squalid tenements on Henry Street and the surrounding neighborhood in the late 19th century prompted nurses Lillian Wald and Mary Maud Brewster to found the Henry Street Settlement in 1893. In recent times, Henry Street continues to be an immigrant neighborhood and has been absorbed into an expanding Chinatown.St. Augustine's Church at 290 Henry Street between Montgomery and Grand Streets was built in 1827–29 as the All Saints' Free Church, and was constructed out of Manhattan schist. The Georgian-Gothic design is credited to architect John Heath. It was designated a New York City landmark in 1966.At the northwest corner of (16–18) Rutgers Street, Henry Street fronts The Roman Catholic Church of St. Theresa, built 1841 for the First Presbyterian Church of New York (PCUSA). In recognition of Henry Street's multicultural history, the Henry Street School for International Studies opened in 2004 at 220 Henry Street. The Henry Street School lower school (grades 6–8) welcomes a diverse group of students from the Bronx, Manhattan, Brooklyn and Queens. The school is one of the New York City Department of Education's small schools and is supported by the Asia Society and the Bill and Melinda Gates Foundation.

The Church of St. Teresa is a Roman Catholic parish located at 16-18 Rutgers Street on the corner of Henry Street in the Lower East Side neighborhood of Manhattan, New York City. The parish is under the authority of the Archdiocese of New York. The church building was constructed in 1841-42 as the Rutgers Presbyterian Church erected in the Gothic Revival style on a plot of ground donated by Colonel Henry Rutgers, and it is said to have oldest public clock in New York City. The church was taken over by St. Teresa's Parish in 1863, only three years after it was founded.A special feature of the New York Times in 1901 mentioned the church among other Catholic structures in the Lower East Side of Manhattan, describing the group "for the most part...limit[ing] themselves to the functions of a parish church, in districts where social needs are otherwise supplied."The AIA Guide to New York City describes the church as “An ashlar church in the tradition of the others nearby, which antedate 1850. This one conducts services in three languages: English, Spanish and Chinese.”

Mesivtha Tifereth Jerusalem (Hebrew: מתיבתא תפארת ירושלים, Mesivta Tiferet Yerushaláyim) (MTJ) is a yeshiva in New York City, and one of the oldest existent yeshivas in the city. It is the institution formerly led by Rabbi Moshe Feinstein, and then led by his son Rabbi Dovid Feinstein until his passing in November 2020. MTJ is now led by Rabbi Berel Feinstein.

Gouverneur Health, formerly Gouverneur Hospital, (pronounced GU-ver-neer) is a municipally owned healthcare facility in New York City affiliated with the New York University School of Medicine. It is located at 227 Madison Street in Lower Manhattan. The facility offers comprehensive healthcare services, including outpatient, specialty, and skilled nursing care. It primarily serves residents of Manhattan, Brooklyn and Queens. Gouverneur Health comprises The Residence at Gouverneur Court, a nursing home with 295 beds; and the Center for Community Health and Wellness, the largest freestanding ambulatory care center in New York State. It originally opened in 1885, and moved to its current location in 1972. A multi-year modernization project was completed in 2014, expanding the facility dramatically. The facility is a member of the New York City Health and Hospitals Corporation.

The East Broadway station is a station on the IND Sixth Avenue Line of the New York City Subway. Located at East Broadway and Rutgers Street in the Lower East Side, it is served by the F train at all times and the train during rush hours in the peak direction. The East Broadway station was built for the Independent Subway System (IND)'s Sixth Avenue Line and opened on January 1, 1936. It contains one island platform and two tracks. The station was initially intended as an interchange station with the Worth Street Line underneath East Broadway, to be built as part of the IND Second System, although the other line was not completed. As a result, the station contains several mezzanines, one of which was originally intended as the platform level of the Worth Street Line. The station has exits to Rutgers Street's intersections with East Broadway and with Madison Street.

Mayor Fiorello H. LaGuardia Houses, also known as LaGuardia Houses, is a public housing development built and maintained by the New York City Housing Authority (NYCHA) on the Lower East Side of Manhattan. Mayor Fiorello H. LaGuardia Houses is composed of thirteen buildings, all of which are sixteen stories tall. The buildings have 1,093 apartments and house approximately 2,596 people. The complex occupies 10.96 acres (4.44 ha), and is bordered by Madison Street to the north, Montgomery Street to the east, Cherry Street to the south, and Rutgers Street to the west. LaGuardia Houses Addition is a sixteen-story tower for elderly people at the corner of Jefferson Street and Cherry Street.

The United States Post Office Knickerbocker Station, originally known as "Station B", is a historic post office building located on East Broadway in Manhattan, New York City. It was built in 1935–37, and designed by consulting architect William Dewey Foster for the Office of the Supervising Architect of the United States Department of the Treasury. The building is a two to three story, brick building with a mansard roof and granite trim in the Colonial Revival style. The main entrance features a three bay wide pavilion topped by a pediment.The building was listed on the National Register of Historic Places in 1989.

The 1958 East River collision occurred on the morning of June 25, 1958, two ships collided in the East River in New York City, resulting in a fire, a gasoline spill, and the deaths of two crewmembers.

Coleman Playground is a public park on the border between the Chinatown and Lower East Side neighborhoods of Manhattan in New York City.