Interstate 470 Bridge

La Belle Iron Works, also known as La Belle Cut Nail Works, was a historic factory complex and national historic district located at Wheeling, Ohio County, West Virginia. The district included four contributing buildings; three Italianate style brick buildings dated to the founding of the company in 1852, and a tin plate mill built 1894–1897. After 1902, the buildings were combined under a single roof, although the truss systems date to different periods achieving the configuration visible today. When listed in 1997, it was known as the "La Belle Cut Nail Plant, The Largest in the World, Wheeling Corrugating Company, A Division of Wheeling Pittsburgh Steel Corporation." The cut nail machinery still in use by La Belle dated to 1852 and the 1860s. The machinery at La Belle along with the different processes were documented by the Historic American Buildings Survey team during the summer of 1990.The plant stopped operation in 2010, and was demolished in 2017.It was listed on the National Register of Historic Places in 1997.

The Bloch Brothers Tobacco Company (formerly the Helme Tobacco Company) of Wheeling, West Virginia was a tobacco company founded by brothers Aaron and Samuel Bloch in 1879. It was best known for its Mail Pouch chewing tobacco. Mail Pouch was a popular chew advertised on over 20,000 barns, most of which were located in the rural Ohio River Valley. Each barn had an end or side painted with the familiar Mail Pouch lettering and advertising, "Treat yourself to the best." The brothers began manufacturing cigars in 1879 as a side-line to Samuel Bloch's wholesale grocery business. It was discovered that the left-over cigar clippings could be flavored and packaged in a paper bag, and then sold. Mail Pouch chewing tobacco is still produced by Swisher International Group.

The Center Wheeling Market is a historic public market located along Market Street between 22nd and 23rd Streets in Wheeling, Ohio County, West Virginia. It consists of the Center Wheeling Market building as well as the Center Wheeling Fish Market. The 1853 Center Wheeling Market building was designed by architect Thomas Pope as an open market. The building is of neo-classical style with three bays and structural cast iron Doric order columns. It has a gable roof and features a belfry complete with bell. The 1890 open brick, neo-Romanesque section was designed by Wheeling architect Edward B. Franzheim. It has brick piers that support a hipped roof with cross gables and a three-foot overhang. In 1900, a wooden enclosure was built at the northern bay to house the Center Wheeling Fish Market.It was listed on the National Register of Historic Places for Ohio County on February 20, 1975. The property is also located in the Centre Market Square Historic District.

Wheeling Historic District, also known as the Wheeling Central Business District, is a national historic district located at Wheeling, Ohio County, West Virginia. The district includes 205 contributing buildings in the central business district of Wheeling. It includes the site of the original location of Fort Henry. The buildings are representative of a number of popular architectural styles from the early-19th century through the present including Greek Revival and Late Victorian. The District was listed on the National Register of Historic Places in 1979.Contributing buildings in the district include: United States Custom House (1859) United States Courthouse, Custom House, and Post Office (1905) St. Matthew's Church and Rectory (c. 1892) Thomas Paull House (c. 1835) English Lutheran Church (1897) designed by Franzheim, Greisey, and Faris First United Presbyterian Church (1825) City Bank Building (c. 1890) also designed by Franzheim, Greisey, and Faris Bank of Wheeling (1892) also designed by Franzheim, Greisey, and Faris, Capitol Theatre (1928), designed by Charles W. Bates Medical Tower Building (1915) Joseph Speidel & Company BuildingIt also includes the West Virginia Independence Hall and Baltimore and Ohio Passenger Terminal (1907-1908), which are listed on the National Register of Historic Places as individual buildings.

Centre Market Square Historic District is a historic district in Wheeling, West Virginia, listed on the National Register of Historic Places. The district includes 181 contributing buildings in a variety of popular architectural styles dating from as early as about 1850. The district encompasses the area of Wheeling focused on the separately listed Center Wheeling Market. Notable buildings include the Second Presbyterian Church (1850), St. Alphonsus Church and School (1875, 1887), Mary A. Reed Building (c. 1885), Shaefer Building (1887), Bellinger Building (c. 1885), Schmeichel Building (c. 1900), Zink House (c. 1878), Lotz Building (c. 1873), Thoner House (c. 1877), Wheeling Public Library (1911), German Evangelical Lutheran Zion's Church (c. 1850, now Oglebay Institute-Towngate Theatre), 2333 Eoff Street (c. 1870–1900), 2227 Eoff Street (c. 1900–1915), 2330 Chapline Street (c. 1876), 2318 Chapline Street (c. 1901), townhouses on Chapline Street, (c. 1870s), 2325 Chapline Street, 2241 Chapline Street, 2233 Chapline Street, the Hellenic Orithodox Church of St. John the Divine (c. 1949–1951), St. John's United Church of Christ (c. 1907–1908), Michel Building (c. 1860–1870), Wheeling Fire Company-Hook and Ladder #6 (late 1870s-1880s), and the "Iron Building" (c. 1867).It was listed on the National Register in 1984, with a boundary increase in 1987.

Chapline Street Row Historic District is a national historic district located at Wheeling, Ohio County, West Virginia. The district encompasses 10 contributing buildings, including eight residences. All buildings are brick with sandstone foundations. The first building was built in 1853, with some buildings added through the 1870s, and the last in 1896. The houses are in the Late Victorian style and are considered an architectural "super block."It was listed on the National Register of Historic Places in 1984.

Wheeling Warehouse Historic District is a national historic district located at Wheeling, Ohio County, West Virginia. The district includes 20 contributing buildings and 11 contributing structures. They are warehouses and commercial style buildings and structures between Main Street and the Ohio River. All of the buildings date to the late-19th and early-20th century. The warehouses are mostly two- and three-story masonry buildings. The two-story commercial buildings have storefronts on the first floor and residential units above. Notable buildings and structures include the Pump Store (1933), Wheeling Stamping Plant (1932), Allied Plate Glass (c. 1920), Warwick China (c. 1887), Boury Warehouse (c. 1894), Ott-Heiskell Company (c. 1871), Edward Wagner Wholesale Grocers building (1915), the Moderne style former Greyhound Bus Station, and Main Street Bridge (1891).It was listed on the National Register of Historic Places in 2002, with a boundary increase in 2022.

Ohio Valley Medical Center (OVMC) was a 200-bed health care facility in Wheeling, West Virginia. It was founded in 1890 as City Hospital. Ohio Valley General Hospital School of Nursing was established on campus in 1892, and was the first school of nursing in the state of West Virginia. OVMC was affiliated with the West Virginia School of Osteopathic Medicine, and had an osteopathic medicine residency program. The residency program offered residencies in internal medicine, emergency medicine, and traditional internal/emergency medicine fields. OVMC was also home to the OVMC School of Radiologic Technology, a two-year hospital based education program. The hospital closed permanently in September 2019.

Robert W. Hazlett House is a historic home located at Wheeling, Ohio County, West Virginia. It was built in 1887, and is a three-story Second Empire style brick residence measuring 30 feet (9.1 m) wide and 112 feet (34 m) deep. It features a central hooded bay and a polychrome slate-covered mansard roof. The interior has many Queen Anne style details. In 1991, it housed Friends of Wheeling, Inc., a private, non-profit, historic preservation organization and four apartments.It was listed on the National Register of Historic Places in 1991.

Wheeling Island Stadium is a stadium used mostly for American football and soccer located on Wheeling Island in Wheeling, West Virginia. The original portion of the stadium was dedicated on June 10, 1927, but a large concrete seating section was added in 1987. The stadium seats 12,220 in two stands along either sidelines, the end zones are empty. Wheeling Island Stadium usually hosts high school football and soccer events but can host concerts, hosting REO Speedwagon most recently in 2009. President John F. Kennedy delivered a speech at the stadium on September 27, 1962. The stadium is owned and operated by Wheeling Park High School. The stadium is also the home of the "Super Six." Each year Wheeling Island plays host to the West Virginia State Football Championships for Class A, AA, AAA. The stadium is considered one of the best high school stadiums in WV, mainly due to capacity and layout of the facility. The Wheeling Island Casino Resort is located within walking distance, providing overnight accommodations for teams. There is plenty of parking adjacent to the stadium, and a private lot adjacent to the south end zone for school personnel, media, and pass holders. The stadium is complete with a 3 level press box with camera deck and private boxes for the coaches. In 2008, a video system was installed at the stadium, several corporate sponsors donated to the project including Wheeling Hospital. Students from Wheeling Park High School's TV station, WPHP-TV, operate the cameras for all Wheeling Park football and soccer games. In 2004, the previous grass surface was replaced with a ProGrass Turf surface. Due to the stadium's location in a high risk flood zone, there is an emergency plan to seal the playing surface in the event of flooding.

The siege of Fort Henry was an attack on American militiamen during the American Revolutionary War near the Virginia outpost known as Fort Henry by a mixed band of Indians in September 1777. The fort, named for Virginia Governor Patrick Henry, was at first defended by only a small number of militia, as rumors of the Indian attack had moved faster than the Indians, and a number of militia companies had left the fort. The American settlers were successful in repulsing the Indian attack.

Fort Henry was a colonial fort which stood about ¼ mile from the Ohio River in what is now downtown, Wheeling, West Virginia. The fort was originally known as Fort Fincastle and was named for Viscount Fincastle, Lord Dunmore, Royal Governor of Virginia. Later it was renamed for Patrick Henry, and was at the time located in Virginia. The fort was subject to two major sieges, two notable feats (McColloch's Leap and Betty Zane's trek through the battle) and other skirmishes.