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The Guardian Bank Building (originally known as the New England Building and later known as the National City Bank Building) is a high-rise building on Euclid Avenue in downtown Cleveland, Ohio.

The Garfield Building is a high-rise building on the corner of Euclid Avenue and E. 6th Street in Cleveland, Ohio, in the United States. It was the first steel frame skyscraper constructed in the city.

PNC Center (formerly National City Center) is a skyscraper located in downtown Cleveland, Ohio at the northwest corner of Euclid Avenue and East 9th Street. The building has 35 stories and rises to a height of 410 feet (120 m), and was designed by Skidmore, Owings and Merrill. Construction on the building was finished in 1980. It served as the headquarters for the now defunct National City Corporation, and is now the Cleveland-area offices for PNC Financial Services.

The Hippodrome Theater was located at 720 Euclid Ave in Cleveland, Ohio. In its day, it was a very lavish theater and ranked as one of the world's greatest playhouses. Performers appearing at the Hipprodome included Enrico Caruso, Sarah Bernhardt, W. C. Fields, Will Rogers, Al Jolson, and John McCormack. The auditorium had two balconies and seating for 3,548. The stage of the Hippodrome could handle large productions and measured 130' wide, 104' deep, 110' high. It also included a water tank for water spectacles. The Hippodrome was demolished in 1981 to make way for a parking lot.

The Citizens Building is a high-rise office and retail building located at 840 Euclid Avenue in Cleveland, Ohio, in the United States. The structure was built in 1903 by the Citizens Savings and Trust, a local bank. Its entrance portico was removed in 1924, and a two-story addition erected in its place. Home to the City Club of Cleveland since 1982, the building was renamed the City Club Building in 1999.

Downtown Cleveland is the central business district of Cleveland, Ohio. The economic and symbolic center of the city and the Cleveland-Akron-Canton, OH Combined Statistical Area, it is Cleveland's oldest district, with its Public Square laid out by city founder General Moses Cleaveland in 1796. Downtown's diverse architecture includes the Cleveland Mall, one of the most complete examples of City Beautiful design in the United States.Downtown is bounded by Lake Erie to the north, the Cuyahoga Valley to the west, and Interstate 90 to the south and east. Its residential population has grown significantly since the 1990s, registering the largest population growth, by percentage, of any Cleveland neighborhood over that time. In 2013, Forbes included Downtown Cleveland in a list of 15 U.S. cities with emerging downtowns. According to Crain's Cleveland Business, its population was estimated to be 20,000 by the end of 2020, making it one of the most populous downtown districts of cities of its size. According to the 2020 U.S. Census data, there are 7,244 occupied units in downtown out of a total 9,569 units, which is a 75.7% occupancy rate and despite Crain’s optimistic numbers, the 2020 census also reports 13,338 people living in the downtown area.

The Beacon is a luxury, residential skyscraper in downtown Cleveland that began construction at 515 Euclid Avenue in late 2017 and was completed in late 2019. The tower rises 350 feet (110 m) tall, with approval from the city council to exceed the city's 250 feet (76 m) limit. The Beacon sits at 29 floors; 8 floors of parking garage, 19 floors of one and two bedroom residential suites and rooftop lounge.Part of the need for the tower is due to the two decade old resurgence of interest in downtown Cleveland. Residential population has up ticked, spearheaded by a 77% increase of new housing units and 95% occupancy rate from 2000 to 2015. This surge in residential growth has seen nearly 15,000 people living in the Cleveland neighborhood as of 2017. That makes downtown Cleveland the largest populated downtown in Ohio (far ahead of Columbus, Cincinnati, and Akron) which illustrates the need for more housing capacity in the central location of Cleveland. It is the third-tallest residential building in the city behind the Terminal Tower, which is slated to be converted into apartments, and The 9 Cleveland.

East 4th Street is a major downtown district in Cleveland, Ohio, known for its food, entertainment, and lack of car traffic. The street runs south from Euclid Avenue to Prospect Avenue. Once a very run down street, the area has been renovated and revitalized by the establishment of numerous restaurants, bars, nightclubs, and apartments, turning it into one of the main nightlife hotspots in the city.

The Schofield Building (previously known as the Euclid Ninth Tower is a high-rise building in downtown Cleveland, Ohio. The 172-foot (52 m), 14-story building is located at the southwest corner of East 9th Street and Euclid Avenue, adjacent to the Rose Building and the City Club Building in the city's Historic Gateway District. Built in 1902 as an office building, the seven lower floors are now home to the Kimpton Schofield Hotel and the upper seven stories house apartments known as the Schofield Residences.

nuCLEus was a proposed mixed-used development complex planned for the Gateway District of downtown Cleveland, Ohio, United States. The project won unanimous approval from the Cleveland Planning Commission in November 2014, and recently received schematic design approval from the City of Cleveland in March 2019 after a thoughtful redesign to fit the city's growing population and needs in downtown Cleveland.Robert L. Stark of Cleveland-based Stark Enterprises is the lead developer on the nuCLEus. The $300M mixed-use project was going to encompass approximately two million square feet in the heart of the city at the intersection between East Fourth Street, Prospect Avenue and Huron Road, connecting many of the venues in the Central Business District. nuCLEus was planned to serve as a mixed-use, vertically integrated space with a mix of Class A office space, retail, restaurants and residential living divided between two distinct, 24 floor towers. At one time, plans included a hotel, but that was later scrapped.

The Arcade in downtown Cleveland, Ohio, is a Victorian-era structure of two nine-story buildings, joined by a five-story arcade with a glass skylight spanning over 300 feet (91 m), along the four balconies. Erected in 1890, at a cost of $867,000 ($26,100,000 in 2021 dollars), the Arcade opened on Memorial Day (May 30, 1890), and is identified as one of the earliest indoor shopping arcades in the United States. The Arcade was modified in 1939, remodeling the Euclid Avenue entrance and adding some structural support. It was designated a National Historic Landmark in 1975.

Fifth Third Center is a skyscraper located in downtown Cleveland, Ohio along Superior Avenue. The building has 27 stories and rises to a height of 446 ft (136 m) with 515,000 square feet (47,800 m2). It is currently the sixth tallest building in Cleveland. It was designed by RTKL Associates and was originally constructed as Bank One Center in 1991. It was renamed in 2003, when Fifth Third Bank of Cincinnati relocated to the structure.