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The Perry Wiles Grocery Company is a historic commercial building in downtown Zanesville, Ohio, United States. Unlike many similar contemporary buildings in the city, it has survived to the present day relatively unchanged, and it has consequently been designated a historic site. When he erected the present building in 1892, Perry Wiles was the owner of one of five grocery wholesalers active in the city of Zanesville, and he and his competitors supplied more than one hundred different individual retail-level grocery stores in the city. Finding the construction of a new building necessary in the early 1890s, Wiles arranged for the services of leading local architect Henry C. Lindsay. The resulting design is a four-story building, built of brick on a stone foundation and finished with details of stone and brick. Although it features some modern elements, such as a cast-iron storefront, the building remains an obvious example of the Romanesque Revival style of architecture. Located adjacent to the original building's southern side is a smaller addition, which was constructed in 1914.By 1980, the Wiles Company had closed, along with all four of its competitors: these firms lost their business when their retailing customers closed, driven out of business by the advent of large supermarket chains. Since that time, the Wiles Company property has been converted into an eating establishment, Zak's Restaurant. In late 1980, the Wiles Company building was listed on the National Register of Historic Places, qualifying because of its place in local history and because of its historically significant architecture. While the headquarters of the five grocery wholesalers may not have been significantly different in their heyday, the passage of time has greatly changed their appearance: the other buildings have all been destroyed or heavily modified, leaving the Wiles Block as Zanesville's only grocery wholesaler building that retains the appearance of a century before.

The Lafayette Lodge No. 79, at 3867 Northpoint Dr. in Zanesville, Ohio, was built in 1991. It is home of Masonic local chapter, La Fayette Lodge No. 79 F&AM and The Lodge of Amity No. 5, F&AM.Further information about the building is available within the Ohio Historic Places Dictionary.

The Adena Court Apartments are an apartment building in downtown Zanesville, Ohio, United States. Built in 1906, the apartments are a well-preserved example of the Colonial Revival style of architecture of the early twentieth century.This three-story apartment building was built for Charles M. Lenhart, a Zanesfield doctor. Born in the countryside of Muskingum County, Lenhart was a leading physician at two Zanesfield hospitals, as well as maintaining his own practice on South Fourth Street in downtown. Consequently, when he decided to erect an apartment building, it was constructed to accommodate his older property; the core of the building is Lenhart's house-and-office building. The unknown architect that he hired to design this structure employed brick for the exterior, along with details of stone and metal. With the structure complete, Lenhart and his family moved into one of the apartments, while another part of the building became his office.In 1980, the Adena Court Apartments were listed on the National Register of Historic Places because of their well-preserved historic architecture.

The Muskingum County Courthouse is a historic building in Zanesville, Ohio. It was designed by T.B. Townsend and H. E. Myer, and built in 1870 with stone, brick, and slate in the Second Empire architecture style. The building is listed on the National Register of Historic Places and is located at 4th and Main Streets. The site served as the capitol of Ohio from October 1, 1810, until May 1, 1812, and the 9th and 10th sessions of the Ohio General Assembly met here at the building that was formerly at the site before those sessions were returned to Chillicothe in May 1812. The former building on the site was then used as the Muskingum County Courthouse until current one was constructed in 1874. The 1809 date stone from the old building was incorporated into the new building and may be seen over the front steps.Townsend was also involved in the building of the third Tuscarawas County Courthouse designed by architect Thomas Boyd and Wood County Courthouse and Jail.

The Masonic Temple Building was a historic building in Zanesville, Ohio. It caught fire on January 6, 2022.

The former United States Post Office and Federal Building is a historic structure in downtown Zanesville, Ohio, United States. Built in 1904, it was designed by Cleveland architect George F. Hammond. The post office and courthouse was listed on the National Register of Historic Places in 1988.

St. Thomas Aquinas Church is a historic church of the Roman Catholic Diocese of Columbus at 130 North. 5th Street in Zanesville, Ohio. The current church was completed in 1842, added to the National Register of Historic Places in 1980, and was under the care of the Order of Preachers until July 2017.

The Zanesville YMCA, at 34 S. Fifth St. in Zanesville, Ohio, was built in 1919. It was listed on the National Register of Historic Places in 1985.It was designed by architect Cyrus McLane and built by the Lorenz Construction Co. McLane was architect of the Rock Island YMCA, in Rock Island, Illinois, and of other YMCA buildings. The building has been destroyed.

The Black-Elliott Block is a historic commercial building in downtown Zanesville, Ohio, United States. Located along Main Street near the Muskingum County Courthouse, it was built in 1876 in the Italianate style of architecture. The partnership of Henry Elliott and Peter Black arranged for the construction of the building; it was one of several significant downtown buildings for which the pair was responsible, along with such important structures as the Clarendon Hotel. At the completion of the building, each man operated his own business inside: of the 31 feet (9.4 m) of building front, Black's store used 16 feet (4.9 m) and Elliott's 15 feet (4.6 m). The building was built of brick on a foundation of sandstone; it also features elements of iron.Both Black and Elliott were prominent Zanesville businessmen: the Baltimore native Elliott founded the city's Elliott Paper Company in 1885 and continued to operate it until his 1899 death, while Black led the First National Bank. From its earliest years, the building was known as the "Black Elliott" block, even in published writings shortly after Black's 1878 death. After the two men's deaths, the most prominent tenant was the S.S. Kresge Company, which operated on the property from 1916 until 1977.In 1979, the Black-Elliott Block was listed on the National Register of Historic Places, qualifying because of its historically significant architecture. Key to this designation was its exterior: no other late nineteenth-century Italianate building survives in downtown Zanesville with so few changes.

The former Zanesville YWCA, located at 49 North 6th Street in Zanesville, Ohio, United States, is an historic building built in 1926 for members of the Young Women's Christian Association. It was designed by Howell & Thomas. On July 17, 1978, it was added to the National Register of Historic Places. It is now Bryan Place.

St. James Episcopal Church is a historic church at 155 N. 6th Street in Zanesville, in the U.S. state of Ohio. It was built in 1843 and added to the National Register in 1978.

The Zanesville Y-Bridge is a historic Y-shaped three-way bridge that spans the confluence of the Licking and Muskingum Rivers in downtown Zanesville, Ohio. It carries the traffic of U.S. Route 40 (Main Street and West Main Street), as well as Linden Avenue.