22nd Street station (SEPTA)

On June 5, 2013, a building undergoing demolition collapsed onto the neighbouring Salvation Army Thrift Store at the southeast corner of 22nd and Market Streets in Center City, Philadelphia, Pennsylvania, trapping a number of people under the rubble. The store was open and full of shoppers and staff. Six people died and fourteen others were injured. The construction contractor, Griffin Campbell, and excavator operator, Sean Benschop, were charged with involuntary manslaughter and other charges. They were found guilty of manslaughter, and Campbell and Benschop received prison sentences of 15 years to 30 years, and 7.5 years to 15 years, respectively.

The College of Physicians of Philadelphia is the oldest private medical society in the United States. Founded in 1787 by 24 Philadelphia physicians "to advance the Science of Medicine, and thereby lessen human misery, by investigating the diseases and remedies which are peculiar to our country" and to promote "order and uniformity in the practice of Physick," it has made important contributions to medical education and research. The College hosts the Mütter Museum, a gallery of 19th-century specimens, teaching models, instruments, and photographs, as well as the Historical Medical Library, which is one of the country's oldest medical libraries.The College of Physicians of Philadelphia Building, designed by the firm of Cope & Stewardson and built in 1909, was designated a U.S. National Historic Landmark in October, 2008. It was also then listed on the National Register of Historic Places.

The Mütter Museum is a medical museum located in the Center City area of Philadelphia, Pennsylvania. It contains a collection of anatomical and pathological specimens, wax models, and antique medical equipment. The museum is part of The College of Physicians of Philadelphia. The original purpose of the collection, donated by Dr. Thomas Dent Mutter in 1858, was for biomedical research and education.

The Murano is a residential skyscraper in Center City, Philadelphia. Part of a condominium boom occurring in the city, the Murano was announced in 2005 and was developed jointly by Thomas Properties Group and P&A Associates. The building, named after Murano, Italy, was completed in 2008 at a cost of US$165 million. The site, previously occupied by a parking lot, was the location of the Erlanger Theatre from 1927 to 1978. The blue glass and concrete, 43-story, 475 feet (145 m) skyscraper was designed by Solomon Cordwell Buenz and Associates. Murano's condos range between 740 square feet (69 m2) and 2,625 square feet (240 m2) and were designed to be loft-like with each featuring a balcony. The building features ground level retail space and an adjacent parking garage. Located in the Logan Square neighborhood of Center City, in a part that first saw residential development in 2002, the building struggled to fill its units during the late-2000s recession. In July 2009 the Murano's owners held a successful auction on forty of the building's units. Thomas Properties Group lowered the price for the remaining unsold units based on what the forty units went for at the auction.

The Erlanger Theatre was a live-performance theater at the northwest corner of 21st and Market Streets in Philadelphia, Pennsylvania. It was built in 1927 by Abraham L. Erlanger, theatrical producer and a founding member of the Theatrical Syndicate. It was demolished in 1978.

The First Unitarian Church of Philadelphia is a Unitarian Universalist congregation located at 2125 Chestnut Street in Philadelphia, Pennsylvania. As a regional Community Center it sponsors cultural, educational, civic, wellness and spiritual activities. On June 12, 1796, twenty of Philadelphia's intellectual leaders formed the First Unitarian Society of Philadelphia, becoming the first continuously functioning church in the country to name itself "Unitarian". The founders were directed and encouraged by the Unitarian minister Joseph Priestley, and its first settled minister was the Rev. Dr. William Henry Furness.

The Science Leadership Academy is a magnet public high school in Philadelphia, Pennsylvania, which opened in September 2006. SLA is a partnership between The Franklin Institute and the School District of Philadelphia. SLA is a 1:1 project-based laptop school where all students and teachers use laptops as their primary learning tool.

Larkin–Belber Building, also known as the Larkin Building and Belber Trunk & Bag Company Building, is a historic light manufacturing loft building located in the Logan Square neighborhood of Philadelphia.

The Jewish Exponent is a weekly community newspaper in Philadelphia, Pennsylvania and the second-oldest continuously published Jewish newspaper in the United States.

The Church of the New Jerusalem was a former nineteenth-century Swedenborgian church located in downtown Philadelphia, Pennsylvania at 22nd and Chestnut Streets.The church was erected in 1881 to designs by Theophilus Parsons Chandler. When the congregation diminished, the church closed in the mid-1980s, and the structure was reused in 1989 as office space. The National Trust for Historic Preservation profiled the structure as a good example of adaptive reuse: "The congregation worked closely with the buyer of the property, the Preservation Fund, and the Philadelphia Historical Commission to devise a design that would be sensitive to the historic fabric." The project "added two floors for office space and enclosed the interior space facing the chancel with a floor to- ceiling glass wall. Updated HVAC, electrical systems, and emergency equipment installed." "In an area of many churches, the successful conversion to office space was a welcome sight for many of the neighbors who had feared an abandoned church building." The 1990 conversion by Mark B. Thompson Associates into 24,000 square feet (2,200 m2) of executive office space with room for expansion for Graduate Health System Corporate Headquarters, and later occupied by the advertising agency The Weightman Group, which is also gone. "Two balconies were added in four of the six bays, leaving the altar area an unchanged space for reception. A glass curtain wall was inserted in the interior to define the space and keep noise down. Additionally, a large spiral staircase and an elevator were placed to give access to all levels."

The First Troop Philadelphia City Cavalry, also known as the First City Troop, is a unit of the Pennsylvania Army National Guard. It is one of the oldest military units in the United States still in active service and is among the most decorated units in the U.S. Army. Accordingly, the Troop operates under a number of principles of self-governance unique in the U.S. military, including the election of unit members and officers, voluntarily forgoing pay for military service to the country, continuing to practice horse cavalry skills and tactics, and recruiting a high percentage of its members from veterans of prior active duty service across all branches (many of whom resign past officer commissions to join), as well as older civilian mid-career professionals. It is the only U.S. military unit that owns its own armory building, built with private funds in Philadelphia's Rittenhouse Square neighborhood. As of November 2017, the troop had 46 active members (33 drilling with the A-1/104th CAV), up from 35 in 2014.

Commerce Square is a Class-A, high-rise office building complex in Center City Philadelphia, Pennsylvania, United States. Commerce Square consists of One and Two Commerce Square, two identical 41-story office towers 565 feet (172 m) high that surround a paved courtyard of 30,000 square feet (2,800 m2). Architecturally, the granite-clad towers feature setbacks on the north and south sides of the building and are topped with a pair of stone diamonds with cutout squares in the center. The towers were built as part an office-building boom Philadelphia was experiencing on West Market Street in the late 1980s. Designed by IM Pei & Partners (now called Pei Cobb Freed & Partners), the towers were developed in a joint venture between Maguire Thomas Partners and IBM. IBM also leased more than half of One Commerce Square for the company's Mid-Atlantic headquarters. Construction of the first phase, which included One Commerce Square, the plaza, and retail space, began in 1985 and was completed in 1987. The project's second phase, Two Commerce Square, did not begin until a lead tenant was secured for the building in 1990. Consolidated Rail Corporation (Conrail) agreed to be Two Commerce Square's lead tenant and make the skyscraper its corporate headquarters after a two-year search for office space in the region. Two Commerce Square ended the skyscraper construction boom of the 1980s when it was completed in 1992. No other office skyscraper was built in Philadelphia until Brandywine Realty Trust (NYSE: BDN) built the Cira Centre in 2005. In the 1990s, Commerce Square's lead tenants reduced their presence dramatically in the towers. IBM moved some of its operations out of Philadelphia in the early 1990s, and Conrail was bought by Norfolk Southern Railway and CSX Transportation later in the decade. Almost all of Conrail's operations were moved out of Philadelphia by the 2000s. Commerce Square was praised mainly for its design of two towers surrounding a plaza. Renowned Philadelphia urban planner Edmund N. Bacon praised Commerce Square and its plaza by saying it "will prove to be one of the finest commercial projects to be built in this century".