Mütter Museum

The College of Physicians of Philadelphia is the oldest private medical society in the United States. Founded in 1787 by 24 Philadelphia physicians "to advance the Science of Medicine, and thereby lessen human misery, by investigating the diseases and remedies which are peculiar to our country" and to promote "order and uniformity in the practice of Physick," it has made important contributions to medical education and research. The College hosts the Mütter Museum, a gallery of 19th-century specimens, teaching models, instruments, and photographs, as well as the Historical Medical Library, which is one of the country's oldest medical libraries.The College of Physicians of Philadelphia Building, designed by the firm of Cope & Stewardson and built in 1909, was designated a U.S. National Historic Landmark in October, 2008. It was also then listed on the National Register of Historic Places.

On June 5, 2013, a building undergoing demolition collapsed onto the neighbouring Salvation Army Thrift Store at the southeast corner of 22nd and Market Streets in Center City, Philadelphia, Pennsylvania, trapping a number of people under the rubble. The store was open and full of shoppers and staff. Six people died and fourteen others were injured. The construction contractor, Griffin Campbell, and excavator operator, Sean Benschop, were charged with involuntary manslaughter and other charges. They were found guilty of manslaughter, and Campbell and Benschop received prison sentences of 15 years to 30 years, and 7.5 years to 15 years, respectively.

The First Unitarian Church of Philadelphia is a Unitarian Universalist congregation located at 2125 Chestnut Street in Philadelphia, Pennsylvania. As a regional Community Center it sponsors cultural, educational, civic, wellness and spiritual activities. On June 12, 1796, twenty of Philadelphia's intellectual leaders formed the First Unitarian Society of Philadelphia, becoming the first continuously functioning church in the country to name itself "Unitarian". The founders were directed and encouraged by the Unitarian minister Joseph Priestley, and its first settled minister was the Rev. Dr. William Henry Furness.

22nd Street station is an underground trolley station in Center City Philadelphia that serves the SEPTA Subway–Surface Trolley Lines. Similar to 19th Street station, three blocks east of it, the station has two side platforms and a total of four tracks. The station serves only subway–surface trolleys on the two outer tracks; the Market-Frankford Line subway uses the two inner tracks and bypasses the station as it travels between 15th Street and 30th Street station. The station was constructed by the Philadelphia Transportation Company in 1955, a replacement for the nearby 24th Street station just north of Market Street at the east end of the now-removed shared train and trolley bridge over the Schuylkill River. The former station site is now the Crown Lights Building (a tall rectangular black skyscraper topped with 4 large LED message boards atop its upper sides), the headquarters of PECO Energy.

The Church of the New Jerusalem was a former nineteenth-century Swedenborgian church located in downtown Philadelphia, Pennsylvania at 22nd and Chestnut Streets.The church was erected in 1881 to designs by Theophilus Parsons Chandler. When the congregation diminished, the church closed in the mid-1980s, and the structure was reused in 1989 as office space. The National Trust for Historic Preservation profiled the structure as a good example of adaptive reuse: "The congregation worked closely with the buyer of the property, the Preservation Fund, and the Philadelphia Historical Commission to devise a design that would be sensitive to the historic fabric." The project "added two floors for office space and enclosed the interior space facing the chancel with a floor to- ceiling glass wall. Updated HVAC, electrical systems, and emergency equipment installed." "In an area of many churches, the successful conversion to office space was a welcome sight for many of the neighbors who had feared an abandoned church building." The 1990 conversion by Mark B. Thompson Associates into 24,000 square feet (2,200 m2) of executive office space with room for expansion for Graduate Health System Corporate Headquarters, and later occupied by the advertising agency The Weightman Group, which is also gone. "Two balconies were added in four of the six bays, leaving the altar area an unchanged space for reception. A glass curtain wall was inserted in the interior to define the space and keep noise down. Additionally, a large spiral staircase and an elevator were placed to give access to all levels."

The Murano is a residential skyscraper in Center City, Philadelphia. Part of a condominium boom occurring in the city, the Murano was announced in 2005 and was developed jointly by Thomas Properties Group and P&A Associates. The building, named after Murano, Italy, was completed in 2008 at a cost of US$165 million. The site, previously occupied by a parking lot, was the location of the Erlanger Theatre from 1927 to 1978. The blue glass and concrete, 43-story, 475 feet (145 m) skyscraper was designed by Solomon Cordwell Buenz and Associates. Murano's condos range between 740 square feet (69 m2) and 2,625 square feet (240 m2) and were designed to be loft-like with each featuring a balcony. The building features ground level retail space and an adjacent parking garage. Located in the Logan Square neighborhood of Center City, in a part that first saw residential development in 2002, the building struggled to fill its units during the late-2000s recession. In July 2009 the Murano's owners held a successful auction on forty of the building's units. Thomas Properties Group lowered the price for the remaining unsold units based on what the forty units went for at the auction.

The Erlanger Theatre was a live-performance theater at the northwest corner of 21st and Market Streets in Philadelphia, Pennsylvania. It was built in 1927 by Abraham L. Erlanger, theatrical producer and a founding member of the Theatrical Syndicate. It was demolished in 1978.

The First Troop Philadelphia City Cavalry, also known as the First City Troop, is a unit of the Pennsylvania Army National Guard. It is one of the oldest military units in the United States still in active service and is among the most decorated units in the U.S. Army. Accordingly, the Troop operates under a number of principles of self-governance unique in the U.S. military, including the election of unit members and officers, voluntarily forgoing pay for military service to the country, continuing to practice horse cavalry skills and tactics, and recruiting a high percentage of its members from veterans of prior active duty service across all branches (many of whom resign past officer commissions to join), as well as older civilian mid-career professionals. It is the only U.S. military unit that owns its own armory building, built with private funds in Philadelphia's Rittenhouse Square neighborhood. As of November 2017, the troop had 46 active members (33 drilling with the A-1/104th CAV), up from 35 in 2014.

The PECO Building is a modernist office highrise in Center City Philadelphia. The building is the current headquarters of the PECO Energy Company, formerly the Philadelphia Energy Company (PECo), and one of the companies that merged to form the Exelon Corporation. The building lies adjacent to the Schuylkill River, extends 27 stories tall, and has the address of 2301 Market Street, Philadelphia, PA 19103.

Harris Building, also known as the Laird, Schober & Company Building, is a historic factory building located in the Logan Square neighborhood of Philadelphia, Pennsylvania. It was built in 1914–1915, and is an eight-story, "L"-shaped, reinforced concrete building clad in brick with terra cotta details. From 1914 to 1942, it housed Laird, Schober & Company, manufacturers of women's, children's, and misses' shoes. It housed a clothing manufacturer until 1985.It was added to the National Register of Historic Places in 2001.

Suburban Station is an art deco office building and underground commuter rail station in Penn Center in Philadelphia. Its official SEPTA address is 16th Street and JFK Boulevard. The station is owned and operated by SEPTA and is one of the three core Center City stations on the SEPTA Regional Rail and one of the busiest stations in the Regional Rail System.The station, which was built by the Pennsylvania Railroad to replace the original Broad Street Station, opened on September 28, 1930.

Larkin–Belber Building, also known as the Larkin Building and Belber Trunk & Bag Company Building, is a historic light manufacturing loft building located in the Logan Square neighborhood of Philadelphia.