Norfolk and Western Railway Company Historic District

Roanoke station is a train station in Roanoke, Virginia, the current southern terminus of Amtrak's Northeast Regional line. Built in 2017, it follows several other Roanoke passenger stations that operated from the 1850s to 1979. The unstaffed station consists of a single high-level platform with no station building or waiting room available for passengers. All tickets must be purchased in advance; there is no Quik-Trak kiosk at the station.

First National Bank, also known as People's Federal Building and Liberty Trust Co., is a historic bank and office building located at Roanoke, Virginia. It was built in 1910, and is a seven-story, granite and buff-colored brick building in the French Renaissance style. It features a Roman Ionic columned main entrance and Doric columns in the main banking hall derived from the Temple of Apollo at Delos.The first director of the bank was Tazewell M. Starkey (1829-1901). In 1926 the bank merged with the National Exchange Bank, and took that name. "When the community opened up, there were a lot of members of the Jewish community who have served on various organizations. For instance, Arthur Taubman was on the board of the First National Exchange Bank, on the board of trustees. When that became Dominion Bank, his son, Nicholas F. Taubman, served on that board of trustees, too."It was listed on the National Register of Historic Places in 1982.

Roanoke Warehouse Historic District, also known as 'Wholesale Row," is a national historic district located at Roanoke, Virginia. It encompasses five contributing buildings constructed between 1889 and 1902. All the buildings are constructed of brick, two-to-four stories in height and three-to-eleven bays in length. Two of the buildings have exceptional corbeled stepped gables in a Dutch-vernacular tradition. The buildings were erected for wholesale food storage.It was listed on the National Register of Historic Places in 1983.

The Wells Fargo Tower (formerly named Dominion Tower, First Union Tower and Wachovia Tower) is a 21-story, 320-foot (98 m) office building in Downtown Roanoke, Virginia. Completed in 1991, this stands as both the tallest building in Roanoke and the tallest building in Southwest Virginia.

Henry Street Historic District is a national historic district located at Roanoke, Virginia. It encompasses four contributing buildings constructed between 1917 and 1951. They were developed as the central business and entertainment district for the African-American neighborhood of Gainsboro in Northwest Roanoke. They are the Hotel Dumas (1917), The Strand Theatre (1923), Dr. Lylburn Downing office (c. 1945), and a commercial building (1951).It was listed on the National Register of Historic Places in 2004. The buildings are also included in the Gainsboro Historic District.

Colonial National Bank, also known as the Colonial-American National Bank and the Colonial Arms Building, is a historic bank and office building located at Roanoke, Virginia. It was built in 1926–1927, and is a 12-story, granite and gray-enamel brick building in the Neoclassical style. The building's design echoes that of a classical column; its first three stories compose the base, its shaft is composed of the next seven stories of unornamented brick, and the top two stories of ornamented brick are the capital. The building has a three-story annex built in two stages in 1949 and 1959. The structure was Roanoke's tallest building for almost fifty years. The office building was listed on the National Register of Historic Places in 1983. It has been renovated numerous times, and as of 2018 housed a bank in its lower floors and upscale apartments in the upper portion.

Campbell Avenue Complex, also known as the Trinkle Buildings, is a historic commercial block and national historic district located at Roanoke, Virginia. It encompasses five contributing buildings constructed between 1892 and 1909. The contiguous three-story buildings are constructed of brick over stone foundations. The buildings have a horizontal arrangement of windows above first-floor storefronts and include buildings representative of the Beaux Arts and Tudor Revival styles.It was listed on the National Register of Historic Places in 1991.

Carilion Roanoke Memorial Hospital (CRMH) is a private teaching hospital in Roanoke, Virginia, USA. With 703 beds, Carilion Roanoke Memorial Hospital is one of the largest hospitals in the state. It is part of Carilion Clinic.The region's only level I trauma center, the hospital operates three medical helicopters (LifeGuard 10, 11, and 12) to provide air ambulance transport, including one in Moneta, one in Christiansburg, and one in Lexington.

Roanoke ( ROH-ə-nohk) is an independent city in the U.S. state of Virginia. It is located in Southwest Virginia along the Roanoke River, in the Blue Ridge range of the greater Appalachian Mountains. Roanoke is approximately 50 miles (80 km) north of the Virginia–North Carolina border and 250 miles (400 km) southwest of Washington, D.C., along Interstate 81. At the 2020 census, Roanoke's population was 100,011, making it the largest city in Virginia west of the state capital Richmond. It is the primary population center of the Roanoke metropolitan area, which had a population of 315,251 in 2020. The Roanoke Valley was originally home to members of the Siouan-speaking Tutelo tribe. However, in the 17th and early-to-mid 18th centuries, Scotch-Irish and later German American farmers gradually drove those Native Americans out of the area as the American frontier pressed westward. In 1882, the Norfolk and Western Railway (N&W) chose the small town of Big Lick as the site of its corporate headquarters and railroad shops. Within two years, the town had become the City of Roanoke. With a 2,300% population growth rate in the decade from 1880 to 1890, the young city experienced the advantages and disadvantages of its boomtown status. During the 20th century, Roanoke's boundaries expanded through multiple annexations from the surrounding Roanoke County, and it became Southwest Virginia's economic and cultural hub. The 1982 decision by N&W to relocate their headquarters out of the city, combined with other manufacturing closures, led Roanoke to pivot to a primarily service economy. In the 21st century, a robust healthcare industry and the development and increased marketing of its outdoor amenities have helped reverse prior declining population trends. Roanoke is known for the Roanoke Star, an 88.5-foot-tall (27.0 m) illuminated star that sits atop a mountain within the city's limits and is the origin of its nickname, "The Star City of the South". Other points of interest include the Hotel Roanoke, a 330-room Tudor Revival structure built by N&W in 1882, the Taubman Museum of Art, designed by architect Randall Stout, and the city's farmer's market, the oldest continuously operating open-air market in the state. The Roanoke Valley features 26 miles of greenways with bicycle and pedestrian trails, and the city's location in the Blue Ridge Mountains provides access to numerous outdoor recreation opportunities.

The Roanoke Downtown Historic District is a national historic district located in the Downtown Roanoke area of Roanoke, Virginia. It encompasses 122 contributing buildings. It includes a variety of commercial, institutional, social, and governmental buildings and structures from the late 19th century to the mid-20th century. Notable buildings include the Roanoke City Public Library, the YMCA Central Branch Building, First Christian Church (1925), the Central Church of the Brethren (1924), Tomnes Cawley Funeral Home (1928), Thomas B. Mason Building (1961), Peerless Candy Co. (c. 1916), City Hall / Municipal Building (1915), Roanoke Times Building (1892), Anchor Building / Shenandoah Building (1910), Greene Memorial Methodist Church (1890), and United States Post Office and Courthouse (1930). Located in the district are the separately listed Patrick Henry Hotel, Boxley Building, Campbell Avenue Complex Historic District, Colonial National Bank, and First National Bank.It was listed on the National Register of Historic Places in 2002.

The Hotel Roanoke & Conference Center is a historic hotel located in the Gainsboro neighborhood of Roanoke, Virginia. Originally built in 1882, the hotel has been rebuilt and expanded many times. The central wing dates to 1938. The hotel is currently owned by Virginia Tech and operated under the Curio Collection by Hilton brand. It was added to the National Register of Historic Places in 1996.

Mill Mountain Theatre (MMT) is a professional equity theatre located in Roanoke, Virginia. Originally opening as Mill Mountain Playhouse as a “not-for-profit, non-Equity resident stock theatre”, the location burned down in 1976, leading to a re-opening and renaming at the Center in the Square in 1983. The theater is named after the nearby Mill Mountain, which is a popular theme for the naming of Roanoke landmarks and organizations, including the Mill Mountain Star, Mill Mountain Zoo, and Mill Mountain Coffee and Tea.Mill Mountain Theatre also has a longstanding relationship with Hollins University and the Hollins Theatre Institute.