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Murray D. Lincoln Campus Center is a high-rise building on the University of Massachusetts Amherst campus, in Amherst, Massachusetts.

The campus of the University of Massachusetts Amherst is located nearly entirely in Amherst, Massachusetts, United States, with a portion located in Hadley. Founded on 310 acres in rural Western Massachusetts, the campus has grown to nearly 1,450 acres.

The College of Social and Behavioral Sciences (SBS) at the University of Massachusetts Amherst is home to the School of Public Policy as well as nine academic departments offering 13 undergraduate majors, 11 areas of Master's and doctoral study, and a number of graduate certificate programs. The college bridges science and liberal arts, encouraging students to pursue cross-disciplinary studies, take classes outside their chosen major, and participate in research projects with faculty mentors. As of 2023, SBS enrolled 3,591 students with a student/professor ratio of 16:1.

The University of Massachusetts Amherst Elaine N. Marieb College of Nursing is a nursing college at the University of Massachusetts Amherst.

The Draper Hall Annex is a single-story office building which houses emergency medical services at the University of Massachusetts Amherst. The building is adjoined to Draper Hall, and has served as an office space, classroom, and at one time, home to the university's polymer science research.

The Campus Pond at the University of Massachusetts Amherst is a pond located in the center of campus that was created in the early 1890s. It is bordered to the south by the Fine Arts Center.

The Ellis Drive Historical Area is an older section of the UMass Amherst containing many of the university's earliest laboratory buildings. Several of these buildings have since been converted for other uses, but research still continues in many of them to this day.

The W. E. B. Du Bois Library is one of the three libraries of the University of Massachusetts Amherst, Amherst, Massachusetts, the others being the Science and Engineering Library, and the Wadsworth Library at the Mount Ida Campus. The W. E. B. Du Bois Library holds resources primarily in humanities and social and behavioral sciences. At 28 stories and 286 feet 4+1⁄8 inches (roughly 88 m) tall, it is the third-tallest library in the world after the National Library of Indonesia in Jakarta at 414 feet (126 m) and Shanghai Library in China at 348 feet (106 m). Measuring taller purely by height, the libraries in Jakarta and Shanghai both only have 24 floors. The W. E. B. Du Bois Library is also considered to be the tallest academic research library (despite claims by UMass that it is the largest) and 32nd tallest educational building in the world. The building maintains a security force, which is managed by various supervisors and student employees. Present holdings at the UMass Libraries include over 4 million titles and over nine million individual items, providing access to over 200,000 online journals, over 1,700,000 e-books, and more than 500 databases. As part of the Five College Consortium, the UMass Amherst Libraries also have access to material from its partners in the Consortium: Amherst College, Hampshire College, Mount Holyoke College, and Smith College. Students can also take advantage of the Interlibrary Loan Services to obtain materials from libraries beyond the Five College system and from all over the world.

The John W. Lederle Graduate Research Center, also known as Lederle Tower or LGRT, is a building in Amherst, Massachusetts. It is part of the University of Massachusetts Amherst. It contains research laboratories, conference rooms, and offices for many departments within the College of Natural Sciences. There is also a substantial amount of classroom space, formerly teaching laboratories, and a large seminar room. The building is also connected to the Lederle Lowrise and other surrounding buildings. The buildings adjacent Lowrise is home to the Science and Engineering Library, one of the two Libraries at the UMass Amherst Campus, the other being the W.E.B. Du Bois Library.

The Justin S. Morrill Science Center, more commonly known as the Morrill Science Center is a research center, lecture hall, and faculty office complex serving the College of Natural Sciences at the University of Massachusetts Amherst. It comprises four buildings that contain research laboratories for several different programs, including the biochemistry, biology, geosciences, microbiology, and public health departments.

The Stockbridge School of Agriculture offers Associate of Science, Bachelor of Science, and graduate degrees as an academic unit of the University of Massachusetts Amherst campus. It was founded as part of the Massachusetts Agricultural College (now University of Massachusetts Amherst) in 1918. The school's main facility and school symbol is Stockbridge Hall, named after Levi Stockbridge, a founder of Massachusetts Agricultural College and its first professor of agriculture; however, its faculty occupies various buildings on the University of Massachusetts campus, including Agricultural Engineering, Bowditch, Clark, Fernald, French, Stockbridge, and West Experiment Station. Research, education, and extension activities occur at the UMass Cold Spring Orchard Research & Education Center, the Hadley Farm (Stockbridge Stables), the Joseph Troll Turf Research Center, the UMass Vegetable & Agronomy Research Farm, and the CNS Greenhouses.

Marshall Hall, otherwise known as Marshall Laboratory, was the first microbiology laboratory at the University of Massachusetts Amherst. Constructed in 1916, it housed the college's microbiology department for a number of years, and was used extensively for bacteriology classes and research. The building was named for Dr. Charles Edward Marshall, the first professor of microbiology at the college, a director of the graduate school, and editor of a textbook on the subject, considered "a standard text for many years." As the microbiology department grew with the university, it soon became necessary for additional research laboratory space. In 1947 the Marshall Hall Annex was placed adjacent to the building; the annex was a former army barrack from Westover Army Airfield in Chicopee, and would continue to be used as a classroom space long after the demolition of its brick cohort. With the expansion and removal of the microbiology department to the Morrill Science Center, and years of substandard maintenance, the original Marshall Hall building was demolished in 1996. The new Integrated Science and Laboratory Science buildings now stand at the site of former microbiology laboratory.