Alexander–Hill House

The Oconee Nuclear Station is a nuclear power station located on Lake Keowee near Seneca, South Carolina, and has a power output capacity of over 2,500 megawatts. It is the second nuclear power station in the United States to have its operating license extended for an additional twenty years by the Nuclear Regulatory Commission (NRC) (the application for the Calvert Cliffs Nuclear Power Plant in Maryland preceded it). This plant has three Babcock & Wilcox pressurized water reactors, and is operated by Duke Energy.

Keowee Key is a lakeside community and census-designated place (CDP) in Oconee County, South Carolina, United States. It is considered part of the Salem community. It was first listed as a CDP prior to the 2020 census with a population of 2,716.The CDP is on the eastern edge of Oconee County, on a peninsula extending into Lake Keowee, a reservoir on the Keowee River and Little River. The arm of the lake on the Little River borders the western side of the peninsula, while the Keowee River arm forms the eastern side and is the border with Pickens County. The two arms of the lake join via a small channel in the south part of the CDP; to the south, across the channel and outside the CDP, is the Oconee Nuclear Station power plant. The Keowee River is a south-flowing tributary of the Seneca River, a main tributary of the Savannah River. South Carolina Highways 130 and 183 traverse the CDP. SC 130 (Stamp Creek Road) leads northwest 8 miles (13 km) to Salem, while SC 183 (Pickens Highway) leads west 11 miles (18 km) to Walhalla, the Oconee county seat. The two highways merge to form Rochester Highway, which leaves the CDP to the south. SC 130 continues south down Rochester Highway 10 miles (16 km) to Seneca, and SC 183 turns east and leads 15 miles (24 km) to Pickens.

Old Pickens Presbyterian Church is a historic church in Seneca, South Carolina.It was built in 1850 and added to the National Register in 1996.

Lake Keowee is a man-made reservoir in the United States in the state of South Carolina. It was developed to serve the needs of power utility Duke Energy and public recreational purposes. It is approximately 26 miles (42 km) long, 3 miles (4.8 km) wide, with an average depth of 54 feet (16 m), and a shoreline measured at 300 miles (480 km) in total, and is approximately 800 feet (240 m) above sea level. The massive demolition and building project began in 1971 with the construction of two large dams––Keowee Dam and Little River Dam, built on the rivers of the same names. The project covered 18,372 acres (74.35 km2). The lake collects or impounds waters from the Keowee River and the Little River and others. The outflows below the respective dams join to form the Seneca River, which flows into the larger Savannah River. Lake water is used to cool Duke Energy's three nuclear reactors located at the Oconee Nuclear Generating Station. In addition, the dams help generate hydroelectric power. The Keowee Hydro Station generates 158 megawatts from the lake's outflows. Lake Keowee has provided a recreational destination for fishing, boating, swimming, sailing, kayaking and other watersports. The lake has been described as having pure and clean water. The name Keowee (ᎨᎣᏫ) is a Cherokee word: it is roughly translated as "place of the mullberries." The historic Keowee Town had been located on the bank of the Keowee River and was the largest of the seven Cherokee Lower Towns in the colonial period, in what became the state of South Carolina. Both the town and the former Keowee River were inundated by the formation of Lake Keowee. Archeological excavations conducted in advance of the project by the University of South Carolina recovered thousands of artifacts, as well as evidence of human and animal remains. There was a traditional burial ground at the town.

Keowee (Cherokee: ᎫᏩᎯᏱ, romanized: Guwahiyi) was a Cherokee town in the far northwest corner of present-day South Carolina. It was the principal town of what were called the seven Lower Towns, located along the Keowee River (Colonists referred to the lower reaches of the river as the Savannah in its lower reaches, with its mouth at the city they named Savannah). Keowee was situated on the Lower Cherokee Traders' Path, part of the Upper Road through the Piedmont. In 1752 the Cherokee established New Keowee Town nearby, off the traders' path but in a more defensible location. Both historic sites are within present-day Oconee County, South Carolina at the foot of the Blue Ridge Mountains. European Americans developed the town of Clemson, South Carolina, south of here after they began to populate the area. When the Keowee River was dammed in a mid-20th century hydropower project, both former Keowee sites were submerged in the early 1970s beneath the waters of Lake Keowee. Before that, archeological excavation was conducted by specialists from the University of South Carolina to establish history and recover thousands of artifacts. Human and animal remains were also discovered at the site.

The Little River originally flowed 27.0 miles (43.5 km) from its headwaters in northern Oconee County, South Carolina near Salem into the Keowee River northeast of Seneca.The Little River was dammed at Newry, South Carolina in the 1890s to power the Newry Mill of the Courtenay Manufacturing Company.In the early 1960s, the lower part of the Little River was flooded by the Lake Hartwell reservoir. In the early 1970s, the Little River Dam was built upstream of Newry as one of two dams to form Lake Keowee. The upstream portion of the Little River remains free flowing.The Little River was in the heart of the Cherokee Lower Towns region. Several Cherokee towns were located along the river.

Fort Prince George was a fort constructed in 1753 in the Province of South Carolina, on the Cherokee Path across the Keowee River from the Cherokee town of Keowee. The fort was named for the Prince of Wales, who would later become King George III of the United Kingdom. It was the principal Carolinian trading post among the Cherokee "Lower Towns".

Newry is a census-designated place in Oconee County, South Carolina. According to the 2020 United States Census, the population of the CDP was 199.

The Issaqueena Bombing Range was a World War II target range used for training flight crews from Greenville Army Air Base, later renamed Donaldson Air Force Base. The Army Air Field was established in 1942 for the preparation of aircrew using North American B-25 Mitchell twin-engine bombers, and a suitable target area was established using Lake Issaqueena, northwest of Calhoun, South Carolina and Clemson University, completely within the Clemson Experimental Forest. Bombing Range Road is still located off of State Highway S-39-291, southwest of Six Mile, South Carolina and west of Lake Issaqueena.

Corinth is an unincorporated community in Oconee County, South Carolina, United States, located 3.7 miles (6.0 km) east-northeast of Seneca.

Salem is a U.S. town in Oconee County, South Carolina. The population was 135 at the 2010 United States Census.

The Keowee River is created by the confluence of the Toxaway River and the Whitewater River in northern Oconee County, South Carolina. The confluence is today submerged beneath the waters of Lake Jocassee, a reservoir created by Lake Jocassee Dam. The Keowee River flows out of Lake Jocassee Dam and into Lake Keowee, a reservoir created by Keowee Dam and Little River Dam. The Keowee River flows out of Keowee Dam to join Twelvemile Creek near Clemson, South Carolina, forming the beginning of the Seneca River, a tributary of the Savannah River. The Keowee River is 25.7 miles (41.4 km) long.The boundary between the Seneca River and the Keowee River has changed over time. In the Revolutionary War period and early eighteenth century, the upper part of the Seneca River was often called the Keowee River, as it was part of the Cherokee homeland. They also had a town named Keowee.In current times, the section of the Keowee River between the Keowee Dam and its confluence with Twelvemile Creek is called the Seneca River on many maps, including the official county highway map. Since this area is flooded by Lake Hartwell, formed by damming the Seneca and Tugaloo rivers, it is natural to refer to this section as the Seneca instead of its proper name. By the early eighteenth century the Cherokee occupied several towns along the upper Keowee River, which were referred to as the Lower Towns. These had long been occupied by indigenous peoples, and each of the larger towns had an earthwork platform mounds built by ancestral people of the South Appalachian Mississippian culture era. The Cherokee typically constructed townhouses, which were their form of public architecture, on top of such mounds if available. Keowee was the principal town of the Lower Towns. Other Cherokee towns on the Keowee River included Etastoe (also spelled Estatoe), and Sugartown (Kulsetsiyi).