Robert E. Kennedy Library

The California Polytechnic State University College of Architecture and Environmental Design (or CAED) is one of Cal Poly San Luis Obispo's six colleges. Cal Poly's CAED program has nearly 1,900 students and is one of the largest programs in the United States. The college offers bachelor's degrees in five departments, as well as two master's degree programs.

The Cal Poly San Luis Obispo College of Engineering is the engineering college of the California Polytechnic State University, San Luis Obispo in San Luis Obispo, California. It has nearly 250 faculty members and more than 6,000 students enrolled in fourteen bachelor's and in eleven master's degree programs through nine engineering departments. Its facilities house more than 80 classrooms, laboratories and work spaces occupying more than 160,000 square feet. In the 2021 U.S. News & World Report's "America's Best Colleges" edition, the College of Engineering is ranked 8th out of 220 public and private undergraduate engineering schools in the U.S. where doctorates are not offered.

The Orfalea College of Business is one of six colleges at California Polytechnic State University in San Luis Obispo, California. The business school was established in 1959 and later named after Paul Orfalea, founder of Kinko’s. The Orfalea College of Business is accredited by the Association to Advance Collegiate Schools of Business (AACSB) and offers a range of undergraduate and graduate programs designed to provide students with practical, hands-on business education. The college is renowned for its strong return on investment, innovative programs, and commitment to fostering entrepreneurship and innovation through its Center for Innovation and Entrepreneurship.

The Powerhouse is a historic building located on the campus of California Polytechnic State University in San Luis Obispo, California. Built from 1909 to 1910, it is the oldest building still standing at Cal Poly. The design of the building was long mis-attributed to William H. Weeks, who had designed the original Cal Poly power house at the northern end of campus. However, the architectural plans for the 1909 building were created by the State of California Department of Engineering, under State Engineer Nat Ellery.The building is designed in the Mission Revival style. The building originally served as a power plant run by students and two full-time supervisors; it also held Mechanics and Electrical Engineering classes. The Powerhouse stopped generating power in the 1940s and was replaced entirely and abandoned in 1955. In 1967, the building found a new use when the school's College of Architecture and Environmental Design decided to hold classes there. The college continued to hold classes in the building even after the construction of a new architecture building, and only stopped in 1990 when the school's administration ordered the building to be abandoned.The Powerhouse was added to the National Register of Historic Places on July 30, 1993.

Mustang Memorial Field, formerly known as Mustang Stadium and then Alex G. Spanos Stadium, is an 11,075-seat multi-purpose stadium on the west coast of the United States, located on the campus of California Polytechnic State University (Cal Poly) in San Luis Obispo, California. It is the home field of the Cal Poly Mustangs football and soccer teams. The stadium was renovated largely from funding via the late Alex Spanos, a Cal Poly alumnus, American billionaire real estate developer, founder of the A. G. Spanos Companies, and then-majority owner of the Chargers of the National Football League (NFL).

California Polytechnic State University, San Luis Obispo (California Polytechnic State University, Cal Poly or Cal Poly San Luis Obispo,) is a public university in San Luis Obispo County, adjacent to the city of San Luis Obispo. It is the oldest of three polytechnics in the California State University system. The university is organized into six colleges offering 65 bachelor's and 39 master's degrees. Cal Poly San Luis Obispo primarily focuses on undergraduate education and as of fall 2020, Cal Poly had 21,447 undergraduate and 840 graduate students. The academic focus is on combining technical and professional curriculums with the arts and humanities. Most of the university's athletic teams participate in the Big West Conference. Cal Poly is eligible to be designated as an Asian American Native American Pacific Islander serving institution (AANAPISI).

University House is the official residence of the President of California Polytechnic State University, San Luis Obispo, located in San Luis Obispo, California.

Robin Baggett Stadium is a baseball venue located on the campus of California Polytechnic State University in San Luis Obispo, California, United States. It is home to the Cal Poly Mustangs baseball team, a member of the Division I Big West Conference. The stadium is named for Robin Baggett, a former baseball player at Cal Poly.

The Robert A. Mott Athletics Center (formerly Mott Gym) is a 3,032-seat, indoor multi-purpose arena on the campus of California Polytechnic State University in San Luis Obispo, California.

The Leaning Pine Arboretum is located on 5 acres (20,000 m2) on the north side of the California Polytechnic State University campus, in San Luis Obispo, central California. In 2022, the Arboretum received a one-million-dollar gift from a former Provost and her husband.

Sierra Vista Regional Medical Center is a 164-bed tertiary acute-care hospital in San Luis Obispo, California, United States. . It is owned by Tenet Healthcare Corporation (NYSE: THC). The hospital is a Level III Trauma Center and offers a range of other services, including neurosurgery, mechanical thrombectomy, a high risk pregnancy program, the only dedicated pediatric unit in San Luis Obispo County and the only NICU in San Luis Obispo County. The hospital is accredited by the Joint Commission on the Accreditation of Healthcare Organizations.

KJDJ is a radio station in San Luis Obispo, California, United States, broadcasting on 1030 kHz AM. It is owned by Centro Cristiano Vida Abundante and is one of three California radio stations that broadcast its Radio Vida Abundante programming with a Spanish-language Christian radio format.