Museo Colonial

The San Francisco Church (Spanish: Iglesia de San Francisco) is a Franciscan church on Avenida Libertador General Bernardo O'Higgins, in the downtown of Santiago de Chile. The church, along with the adjacent convent, is one of the oldest colonial-era buildings in the country. It has been resistant to about 15 earthquakes of magnitude over 7.

Londres 38 is a building that was used by the National Intelligence Directorate (DINA) as a detention and torture center for opponents of Augusto Pinochet's dictatorship. The facility is located in downtown Santiago, Chile, and was known in DINA's jargon by the code name Yucatán.

Barrio París-Londres is a barrio located in Santiago, Chile. The neighborhood intersects at Calle Londres and Calle París, located behind the San Francisco Church, in its former orchard. Barrio París-Londres features shops, hostels, hotels and cobble stone streets with renovated mansions, reminiscent of the Latin Quarter in Paris, France. The barrio was developed in 1923 by a group of architects, and consists of only two streets. The building at Calle Londres 38/40 is a former jail and torture facility, used during the Pinochet regime. Tiles in front of the building depict the names of former political prisoners who were held there.

Universidad de Chile (in Spanish: University of Chile) station is a transfer station between the Line 1 and Line 3 of the Santiago Metro. It is an underground station located between La Moneda and Santa Lucía stations on the same line. It is located at the junction of Avenida Libertador General Bernardo O'Higgins, also known as "Alameda", and Paseo Ahumada in the commune of Santiago. The Line 1 station was opened on 31 March 1977 as part of the extension of the line from La Moneda to Salvador. The Line 3 station was opened on 22 January 2019 as part of the inaugural section of the line, from Los Libertadores to Fernando Castillo Velasco.

The National Library of Chile (Spanish: Biblioteca Nacional de Chile) is the national library of Chile. It is located on the Avenida Libertador General Bernardo O'Higgins in Santiago, in a building completed in 1925, though its history reaches to the early nineteenth century before it was relocated to its current home.

The Teatro Municipal, National Opera of Chile is the most important stage theatre and opera house in Santiago, Chile.

Santa Lucia (in Spanish: Saint Lucy), is a station on the Santiago Metro in Santiago, Chile. It is underground, between the stations Universidad de Chile and Universidad Católica on the same line. It is located on Avenida Libertador General Bernardo O'Higgins, in the commune of Santiago. The station was opened on 31 March 1977 as part of the extension of the line from La Moneda to Salvador.It has a regular flow of passengers that increases during the Metro's rush hours (mornings and afternoons). The station is in a mix of residential, business and educational zones. In the immediate surroundings of the station, to the northeast is Santa Lucia Hill, and just by the North exit also is the National Library of Chile, a National Monument building located along the North sidewalk of Avenida Libertador General Bernardo O'Higgins. The station also is to the Avenida Miraflores and Avenida Santa Rosa, this latter being a major traffic axis.

Instituto Nacional General José Miguel Carrera, often shortened to Instituto Nacional (National Institute), is a public boys' school in downtown Santiago, Chile which teaches 4.400 students between 7th and 12th grade. 170 teachers are employed.The school was founded on August 10, 1813 by José Miguel Carrera. Its official name is Liceo Ex A-0 - Instituto Nacional General José Miguel Carrera. The Instituto Nacional is one of the few public schools in Chile's largely privatized educational landscape. The school played a role in the long-running student protests for fairer education policies in 2006. When the protests began in 2019 with the increase in metro prices, the students at the Instituto Nacional called for collective fare evasion.

Iglesia de San Agustín — Our Lady of Grace, commonly known as Church of St Augustine or Templo de San Agustín, is owned by the Order of Saint Augustine. It is a Catholic church, located at the southeast corner of Agustinas and Estado streets, in downtown Santiago, Chile.

The Casa Central de la Universidad de Chile, also known as Palacio de la Universidad de Chile, is the main building for the Universidad de Chile, and is located at 1058 Alameda Libertador Bernardo O'Higgins, in Santiago, Chile. The building dates from 1872, and currently houses the rectorate, rooms used for ceremonial events and the Andrés Bello Archives, so-named to honor the lawyer who founded the university. It was declared a National Monument of Chile in 1974. The adjacent Universidad de Chile metro station was named after the building.

The National Archives of Chile (Spanish: Archivo Nacional de Chile) is a public organization of the Chilean state, created in 1927 with the goal to "collect and conserve the archives of the Departments of State and all the documents and manucsrpits related to the national history, and to oversee their organization and use.". It is treated as a dependent organization of the Dirección de Bibliotecas, Archivos y Museos (Direction of Libraries, Archives, and Museums), which is administered by the Consejo Nacional de la Cultura y las Artes de Chile (National Council on Culture and the Arts).

Edificio Ariztía is a building located at 52 Nueva York Street in downtown Santiago, Chile, on a wedge-shaped city block. It was completed in 1921 and is considered the first "skyscraper" in Santiago. The building, constructed in reinforced concrete, was the first office building in Santiago with an elevator.