Parque Urbano Dora Colón Clavell

Monumento a la Mujer is a bronze statue commemorating the contributions of the Puerto Rican women to the Puerto Rican society. It is located at the fork of Calle Marina and Calle Mayor Cantera, in Ponce, Puerto Rico, next to Parque Urbano Dora Colón Clavell, in Barrio Cuarto. It was unveiled in 2002. Its sculptor was Maria Elena Perales. The monument was the first and, at the time, the only one of its kind "in Puerto Rico and the Caribbean."

The Escuela Hemeterio Colón y Warens (English: Hemeterio Colón y Warens School), also widely referred to as La Hemeterio or La Colón, is a public, intermediate school serving the city of Ponce, Puerto Rico. Its original, main building, built in 1913, is architecturally significant as a well-preserved example of the Puerto Rican school buildings of the early 20th century, a period of great transformation in Puerto Rico under the American administration. It was designed by insular architect Albert B. McCulloch using the California Mission Revival and Classical Revival styles, as well as some Modernist elements associated with the work of Antonin Nechodoma.The school was entered on the U.S. National Register of Historic Places in 2022.

The Museo de la Masacre de Ponce (the Ponce Massacre Museum) is a human rights museum and historic building in Ponce, Puerto Rico. It depicts the history and events surrounding the Ponce massacre, which occurred in broad daylight on Palm Sunday in 1937. The museum is housed inside the building where the event itself occurred, with one of its sections devoted to the Nationalist leader, Pedro Albizu Campos. It also documents the blacklisting of Puerto Rican Nationalists performed by the United States, as well as hosting a considerable number of photos from the Nationalist era.The museum is listed in the U.S. National Register of Historic Places in as Casa de la Masacre (the Massacre House).

The Ponce massacre was an event that took place on Palm Sunday, March 21, 1937, in Ponce, Puerto Rico, when a peaceful civilian march turned into a police shooting in which 19 civilians and two policemen were killed, and more than 200 civilians wounded. None of the civilians were armed and most of the dead were reportedly shot in their backs. The march had been organized by the Puerto Rican Nationalist Party to commemorate the abolition of slavery in Puerto Rico by the governing Spanish National Assembly in 1873, and to protest the U.S. government's imprisonment of the Party's leader, Pedro Albizu Campos, on sedition charges.An investigation led by the United States Commission on Civil Rights put the blame for the massacre squarely on the U.S.-appointed governor of Puerto Rico, Blanton Winship. Further criticism by members of the U.S. Congress led President Franklin D. Roosevelt to remove Whinship as governor in 1939.Governor Winship was never prosecuted for the massacre and no one under his chain of command – including the police who took part in the event, and admitted to the mass shooting – was prosecuted or reprimanded.The Ponce massacre remains the largest massacre in US imperial history in Puerto Rico. It has been the source of many articles, books, paintings, films, and theatrical works.

The Iglesia de la Santísima Trinidad (Holy Trinity Church) was organized by British residents in Ponce, Puerto Rico, as an Anglican congregation in 1869. They built their first church of wood and metal at this site in 1873, aided by materials sent by Queen Victoria's government, including a bell cast in England in 1870. Located at the intersection of Marina, Mayor, and Abolicion streets, it was the first Anglican church built on the island. Holy Trinity was still the only Protestant church in Puerto Rico at the time of the United States invasion in 1898. Because the old church had deteriorated, it was taken down; and a new church building was constructed on the same site in 1926. It has a synthesis of English neo-Gothic and Spanish-colonial styles. The 1870 bell was installed in the new church. The architect or designer is unknown. The church was listed on the U.S. National Register of Historic Places on 29 September 1986.

The Zaldo de Nebot Residence (Spanish: Residencia Zaldo de Nebot), also known as the Fornaris Residence, is a historic house in Ponce, Puerto Rico. Built to a Neoclassical design in 1895, it is one of the fullest expressions of 19th century architecture for Ponce's wealthy creole class. Notable are the trompe-l'œil interior wall paintings of Parisian landmarks and fin de siècle decorative detailing.The house was entered on the National Register of Historic Places in 1988.

Casa Paoli (English: Paoli House) is a historic house and biographical museum in barrio Cuarto, Ponce, Puerto Rico, in the Ponce Historic Zone. The house is significant as the birthplace of Antonio Paoli (1871–1946), a tenor who was the "first Puerto Rican to reach international recognition in the performing arts" and "one of the most outstanding opera singers of all times". The house was the childhood home of the artist and he was introduced to art and opera at this house during his formative years. In 1987, the house was turned into a museum to honor the career of Antonio Paoli. The building was listed on the U.S. National Register of Historic Places in 2009.

The Antiguo Casino de Ponce (English: Old Ponce Casino), or simply the Casino de Ponce, is a historic structure, built in 1922 and located in Barrio Cuarto, Ponce, Puerto Rico. Originally built as a social club for Ponce's elite, it is currently used as the premier reception center of "The Noble City of Puerto Rico". The building, designed by Agustin Camilo Gonzalez in the Second Empire and Neo-Rococo styles, has a French facade and tones. It was listed in the National Register of Historic Places on 28 October 1987. It is located at the corner of Marina and Luna streets. The building has been called "an icon of Ponce's architecture, history, and identity." It is owned and administered by the Ponce Municipal Government. In 1936, during the Great Depression, the Casino declared bankruptcy and shut down. It subsequently had various uses: a postal office, a public health unit, tax collector's office, and even a temporary city hall. In 1990 it was restored by the Ponce Municipal Government, and has since been used for high-ranking official municipal business. For example, it was here where the dinner to honor Prince of Asturias, His Majesty Felipe de Borbon, took place.

Parque de la Abolición (English: Abolition Park) is a city park in Barrio Cuarto, Ponce, Puerto Rico. It was the first park in the Caribbean to commemorate the abolition of slavery. It was built in 1874 and renovated in 1956.

Concha Acústica de Ponce (English: Ponce Acoustic Shell) is an open-air music and performing arts amphitheater venue in Barrio Cuarto, Ponce, Puerto Rico, owned and managed by the Ponce Municipal Government. It is located on the grounds of Parque de la Abolición. The open-air auditorium-amphitheater is used primarily for cultural events. It is open from Monday through Friday, 8:00AM to 4:30PM. Concha Acústica, as it is known today (2017), is the result of a 1956 redesign that also included the adjacent Monumento a la abolición de la esclavitud. The original design was augmented by this 1956 redesign/renovation by Francisco Porrata-Doría (1890–1971).

Casa Oppenheimer (English: Oppenheimer House) is a historic house in Ponce, Puerto Rico, designed in 1913 by famed Puerto Rican architect Alfredo B. Wiechers. The house is unique among other historic structures in historic Ponce for its skillful incorporation of front gardens in a very limited urban space. The historic building is located at 47 Salud Street, in the city's historic district, at the northwest corner of Salud and Aurora streets. The house is also known as Casa del Abogado (House of the Attorney). In April 2019, the house was turned into Casa Mujer by MedCentro, a women's health business concern.

El Hombre Redimido (English: Man redeemed) is a bronze statue by Victor Cott that commemorates the abolition of slavery in Puerto Rico. It is located on Avenida Hostos at the fork of Calle Salud and Calle Marina streets, in Barrio Cuarto, Ponce, Puerto Rico.