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Ralph L. Fike High School is a high school in Wilson, North Carolina. Fike High School opened its doors to students on October 9, 1958. It is named for Dr. Ralph Llewellyn Fike (1905–1959), a physician, educator, and community leader. Fike High School is the sole International Baccalaureate school in Wilson County.

Wilson is a city in and the county seat of Wilson County, North Carolina, United States. It is the 23rd most populous city in North Carolina. Located approximately 40 mi (64 km) east of the capital city of Raleigh, it is served by the interchange of Interstate 95 and U.S. Route 264. Wilson had an estimated population of 49,459 in 2019, according to the U.S. Census Bureau, and is also an anchor city of the Rocky Mount-Wilson-Roanoke Rapids CSA, with a total population of 297,726 as of 2018. In the early 21st century, Wilson was ranked as 18th in size among North Carolina's 500-plus municipalities. From 1990 to 2010, the city population increased by more than 40 percent, primarily due to construction of new subdivisions that attracted many new residents. This has been accompanied by new retail and shopping construction, primarily in the northwestern parts of the city. Wilson is a diverse community; in 2012, the US Census estimated that 48% of the population identified as African American, and 43% as Whites; the remaining 9% includes Latinos and Asians, such as Vietnamese, Chinese and Indians. The U.S. Census Bureau estimated in 2012 that nearly 5,000 county residents (7.5 percent) were foreign-born. Of those, nearly 3,000 people, or 62 percent, had entered the U.S. since 2000. Once a center of tobacco cultivation, the city was widely known as "The World’s Greatest Tobacco Market" in the 19th century. In the 21st century, Wilson enjoys a diverse economy based on agriculture, manufacturing, commercial, and service businesses.

West Nash Street Historic District is a national historic district located at Wilson, Wilson County, North Carolina. It encompasses 79 contributing buildings in a predominantly residential section of Wilson. The district largely developed during the 1910s and 1920s and includes notable examples of Colonial Revival and Bungalow / American Craftsman style architecture. Notable buildings include the William W. Graves House, Selby Hurt· Anderson House, Williams-Cozart House, John T. Barnes House, Graham-Woodard House, M. Douglas Aycock House (1925-1928), John D. Gold House, Boykin's Filling Station, and West End Grocery. It was listed on the National Register of Historic Places in 1984.

Wilson Medical Center is a 294-bed hospital located in Wilson, North Carolina, serving Wilson and the surrounding counties. It was established in the 1960s and is the only hospital located in Wilson County. The hospital's chief executive is Christopher Munton.

The Wilson Central Business–Tobacco Warehouse District is a national historic district located at Wilson, Wilson County, North Carolina. It encompasses 152 contributing buildings, 20 contributing sites, and 2 contributing structures in the central business district of Wilson. The district includes notable examples of Late Victorian and Art Deco style architecture. Located in the district are the separately listed Branch Banking Building, Cherry Hotel, and Wilson County Courthouse. Other notable buildings include the Woodard-Watson Warehouse, Planter's Warehouse, Passenger Station and Freight Depot (1924), Jackson Chapel First Baptist Church (1913), St. John's African Methodist Episcopal Church (1915), Imperial Tobacco Company (c. 1903, c. 1910, 1919), Winstead-Hardy Building (c. 1866), Rountree Building (1870s), Planter's Bank Building (1920), United States Post Office and Courthouse (1927), Charles L. Coon High School (1922), First National Bank of Wilson Building (1927), Wilson Theatre (1922), Odd Fellows Lodge (1896), and the Works Projects Administration financed Wilson Municipal Building (1938). It was listed on the National Register of Historic Places in 1984.

Moses Rountree House is a historic home located at Wilson, Wilson County, North Carolina. It was built about 1869, and is a two-story, three bays wide by two bays deep, Gothic Revival style frame house. It has a two-story rear ell. It has a steep gable roof and is sheathed in weatherboard. The house was moved in 1890 and about 1920, and was renovated in the 1930s adding Colonial Revival style design elements. It was listed on the National Register of Historic Places in 1982.

Olzie Whitehead Williams House is a historic home located near Wilson, Wilson County, North Carolina. It was built about 1860, and is a single-story, six-bay, L-shaped, Italianate style frame house with a gabled projecting end pavilion. It rests on a low brick pier foundation and is sheathed in weatherboard. The front facade features a shed roofed verandah. It was listed on the National Register of Historic Places in 1983.

Davis-Whitehead-Harriss House is a historic home located at Wilson, Wilson County, North Carolina. It was built in 1858, and renovated in 1872 in the Italianate style. It is a two-story, three bays wide, "T"-plan, frame dwelling, with a rear ell. It has single-shouldered, brick end chimneys with stuccoed stacks and a one-story, hipped roof front porch. Also on the property is a two-story frame carriage house built in 1925. It was listed on the National Register of Historic Places in 1982.

Barton College is a private liberal arts college in Wilson, North Carolina. It is affiliated with the Christian Church (Disciples of Christ). It offers 29 majors and 7 minors as well as 6 master's degrees.

Broad–Kenan Streets Historic District is a national historic district located at Wilson, Wilson County, North Carolina. It encompasses 293 contributing buildings in a predominantly residential section of Wilson. The district developed between about 1890 to 1940 and includes notable examples of Colonial Revival, Bungalow / American Craftsman, and Queen Anne style architecture. Notable buildings include the Woman's Club of Wilson (1922). It was listed on the National Register of Historic Places in 1988.

Montclair is an unincorporated community in Wilson County, North Carolina, United States. It lies at an elevation of 108 feet (33 m).

The Old Wilson Historic District in Wilson, North Carolina is a 164-acre (66 ha) historic district that was listed on the National Register of Historic Places (NRHP) in 1984. It includes work dating from 1853 and work designed by architect Solon Balias Moore and others. The listing included 263 contributing buildings, one contributing site, one contributing structure, and three contributing objects. It includes the separately NRHP-listed Moses Rountree House and the NRHP-listed Davis-Whitehead-Harriss House.