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The Harbor Bridge Project (or New Harbor Bridge or US 181 Harbor Bridge) is the replacement of the existing through arch bridge that crosses the Corpus Christi Ship Channel, which serves the Port of Corpus Christi in Corpus Christi, Texas, with a modern cable-stayed bridge design. The route will connect with SH 286 (the Crosstown Expressway) at its southern terminus and US 181 on the north. Groundbreaking on construction took place on August 8, 2016 and was scheduled to be completed by the spring of 2020, but was extensively delayed due to engineering and design issues, and is tentatively planned to be completed in 2025.

The Corpus Christi Museum of Science and History is a science and history museum in Corpus Christi, Texas, near Corpus Christi Harbor Bridge and the waterfront. It was established in 1957. Among its many displays covering an area of over 40,000 square feet are many artifacts found in the wreck of the Spanish ship San Estaban, including the world's oldest mariner's astrolabe with a confirmed date of 1554. An extension to the museum opened in May 1990 to house the Shipwreck! exhibition.

The Corpus Christi Harbor Bridge is a through arch bridge located in Corpus Christi, Texas which carries six lanes of U.S. Route 181 (US 181) and Texas State Highway 35 (SH 35) from downtown Corpus Christi to Rincon Point, known to locals as North Beach. The harbor bridge crosses the Corpus Christi Ship Channel and handles nearly 26,000 vehicles daily. A new bridge called the New Harbor Bridge is currently under construction. When complete it will allow larger ships to pass beneath, permit safer pedestrian transit, and reconfigure the entire highway interchange system in the surrounding community.

The American Bank Center is an entertainment complex located in Corpus Christi, Texas. The complex consists of an auditorium, convention center and arena. The facility hosts numerous conventions, trade shows, exhibitions, live performances and sporting events. It is home to the Corpus Christi IceRays Tier II Jr. A ice hockey team and the Texas A&M–Corpus Christi Islanders men's and women's NCAA basketball teams. It is owned by the city of Corpus Christi and managed by ASM Global.

The Art Museum of South Texas, located in Corpus Christi, Texas, is an art museum which was established in 1936.

The Port of Corpus Christi is the largest port in the United States in total revenue tonnage, third largest in total waterway tonnage, and the largest crude oil export gateway in the nation. The Port of Corpus Christi is located on Corpus Christi Bay in the western Gulf of Mexico, with a 36-mile channel that is being widened and deepened to 54 feet MLLW from its current depth of 45 feet.The Port of Corpus Christi’s headquarters, the Executive Administration Building, is located near the entrance the Inner Harbor (adjacent to Downtown Corpus Christi) in Nueces County. The Port operates as an independent subdivision of the State of Texas and is governed by state Navigation Code. The Port of Corpus Christi’s operations are funded without any city, county or state tax dollars.

Old Bayview Cemetery is a cemetery located on a small hill in downtown Corpus Christi, Texas on Ramirez St. at Padre St., bordered by the I-37 access road. It is the oldest federal military cemetery in Texas. Owned by the City of Corpus Christi, it presently comprises three and a half acres as a Historic Texas Cemetery and a State Archaeological Landmark of the Texas Historical Commission. The cemetery was listed on the National Register of Historic Places in 2020.

The Texas State Aquarium is a nonprofit aquarium located in Corpus Christi, Texas, United States. It aims to promote environmental conservation and rehabilitation of the wildlife of the Gulf of Mexico. It has been accredited by the Association of Zoos and Aquariums (AZA) since 1995. It is the largest aquarium in Texas and one of the largest aquaria in the United States.

The Old Nueces County Courthouse is a historic government building in downtown Corpus Christi, Texas, United States. All functions at the courthouse relocated to the current county courthouse just a few streets away. The old courthouse was listed on the National Register of Historic Places in 1976. There are currently ongoing efforts to restore the old courthouse, which is being worked on by county government.

USS Lexington (CV/CVA/CVS/CVT/AVT-16) is an Essex-class aircraft carrier built during World War II for the United States Navy. Originally intended to be named Cabot, the new aircraft carrier was renamed while under construction to commemorate the recently-lost USS Lexington (CV-2), becoming the sixth U.S. Navy ship to bear the name in honor of the Battle of Lexington. Lexington was commissioned in February 1943 and saw extensive service through the Pacific War. For much of her service, she acted as the flagship for Admiral Marc Mitscher, and led the Fast Carrier Task Force through their battles across the Pacific. She was the recipient of 11 battle stars and the Presidential Unit Citation. Following the war, Lexington was decommissioned, but was modernized and reactivated in the early 1950s, being reclassified as an attack carrier (CVA). Later, she was reclassified as an antisubmarine carrier (CVS). In her second career, she operated both in the Atlantic/Mediterranean and the Pacific, but spent most of her time, nearly 30 years, in Pensacola, Florida, as a training carrier (CVT). Lexington was decommissioned in 1991, with an active service life longer than any other Essex-class ship. Following her decommissioning, she was donated for use as a museum ship in Corpus Christi, Texas. In 2003, Lexington was designated a National Historic Landmark. Though her surviving sister ships Yorktown, Intrepid, and Hornet carry lower hull numbers, Lexington was laid down and commissioned earlier, making Lexington the oldest remaining fleet carrier in the world.

Wells Fargo Tower (also known as Norwest Tower and Robert Driscoll Hotel) is a 20-story high-rise office building located at 615 North Upper Broadway Street in the city of Corpus Christi, Texas, United States. At the time of its completion in 1942, it was the tallest building in the city, and remained so for several decades. The building open on May 25, 1942, and it was built by Clara Driscoll and named after her father Robert Driscoll.

One Shoreline Plaza in Corpus Christi, Texas overlooks Corpus Christi Bay and consists of 2 skyscrapers, north and south, south being the tallest, and the tallest building in South Texas south of San Antonio. It is the most prominent figure in the skyline of the city.