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The Lawrence Hall of Science is a public science center in Berkeley, California that offers hands-on science exhibits, designs curriculum, aids professional development, and offers after school science resources to students of all ages. The Hall was established in 1968 in honor of physicist Ernest Orlando Lawrence (1901–1958), the University of California's first Nobel laureate. The Hall is located in the hills above the University of California, Berkeley campus, less than a mile uphill from the University's Botanical Garden.

Lawrence Berkeley National Laboratory (LBNL), commonly referred to as Berkeley Lab, is a United States national laboratory that conducts scientific research on behalf of the Department of Energy. Located in the hills of Berkeley, California, the lab overlooks the campus of the University of California, Berkeley.

The Mathematical Sciences Research Institute (MSRI) is an independent nonprofit mathematical research institution in Berkeley, California. It is widely regarded as a world leading mathematical center for collaborative research, drawing thousands of leading researchers from around the world each year.MSRI was founded in 1982, and its funding sources include the National Science Foundation, foundations, corporations, and more than 90 universities and institutions. The Institute is located at 17 Gauss Way on the University of California, Berkeley campus, close to Grizzly Peak in the Berkeley Hills.Because of its contribution to the nation’s scientific potential, MSRI’s activity is supported by the National Science Foundation and the National Security Agency. Private individuals, foundations, and nearly 100 Academic Sponsor Institutions, including the top mathematics departments in the United States, provide crucial support and flexibility. James Simons, founder of Renaissance Technologies and a University of California, Berkeley alumnus, is a long-time supporter of MSRI and serves as a member of the Board of Trustees.

The Space Sciences Laboratory (SSL) is an Organized Research Unit (ORU) of the University of California, Berkeley. Founded in 1959, the laboratory is located in the Berkeley Hills above the university campus. It has developed and continues to develop many projects in the space sciences, including the search for extraterrestrial life (SETI@home).

The Advanced Light Source (ALS) is a research facility at Lawrence Berkeley National Laboratory in Berkeley, California. One of the world's brightest sources of ultraviolet and soft x-ray light, the ALS is the first "third-generation" synchrotron light source in its energy range, providing multiple extremely bright sources of intense and coherent short-wavelength light for use in scientific experiments by researchers from around the world. It is funded by the US Department of Energy (DOE) and operated by the University of California. In June 2018, Stephen Kevan became the director of the ALS.

The Molecular Foundry is a nanoscience user facility located at the Lawrence Berkeley National Laboratory in Berkeley, California, and is one of five Nanoscale Science Research Centers sponsored by the United States Department of Energy.

The U.S. Department of Energy (DOE) Joint Genome Institute (JGI), first located in Walnut Creek then Berkeley, California, was created in 1997 to unite the expertise and resources in genome mapping, DNA sequencing, technology development, and information sciences pioneered at the DOE genome centers at Lawrence Berkeley National Laboratory (Berkeley Lab), Lawrence Livermore National Laboratory (LLNL) and Los Alamos National Laboratory (LANL). As a DOE Office of Science User Facility of Berkeley Lab, the JGI staff is composed of employees from Berkeley Lab, LLNL and the HudsonAlpha Institute for Biotechnology. The JGI also collaborates with other DOE-supported programs and facilities, such as the Environmental Molecular Sciences Laboratory at Pacific Northwest National Laboratory (PNNL), the National Energy Research Scientific Computing Center, or NERSC, and the DOE Bioenergy Research Centers.

The Big "C" is a giant concrete block of the letter "C" built into Charter Hill in the Berkeley Hills overlooking the University of California, Berkeley. The very well known symbol is celebrated in a number of Cal songs and in the San Francisco Bay Area, especially on campus. It celebrates over one hundred years of athletic and academic excellence at the university. On March 23, 1905, the Big "C" was constructed on Charter Hill, where it has remained to this day.

The Bevatron was a particle accelerator — specifically, a weak-focusing proton synchrotron — at Lawrence Berkeley National Laboratory, U.S., which began operating in 1954. The antiproton was discovered there in 1955, resulting in the 1959 Nobel Prize in physics for Emilio Segrè and Owen Chamberlain. It accelerated protons into a fixed target, and was named for its ability to impart energies of billions of eV. (Billions of eV Synchrotron.)

Levine-Fricke Field is a college softball stadium in Berkeley, California, on the campus of the University of California. Opened in 1995, it is the home field of the California Golden Bears of the Pac-12, with a seating capacity of 1,204. Levine-Fricke Field is located in the Strawberry Canyon just east of California Memorial Stadium and Witter Rugby Field.

The National Center for Electron Microscopy (NCEM) was a U.S. Department of Energy national user facility at Lawrence Berkeley National Laboratory in Berkeley, California, for unclassified scientific research using advanced electron microscopy. It has since been merged with the Molecular Foundry, also located at Berkeley Lab.

The Weston Havens House is a historic Modernist and International Style house in the Panoramic Hill neighborhood of Berkeley, California, built in 1940. John Weston Havens Jr. (1903–2001) commissioned the architect Harwell Hamilton Harris (1903–1990) to design a custom house suited to Havens' interests and preferences. The Weston Havens House was listed on the National Register of Historic Places on June 11, 2008. It is recognized as an example of regional California Modernist style, with its radical design that looks outward from the hill to a view of the Pacific, along with its use of materials such as Douglas fir and redwood.