The Culinary Institute of America at Greystone

The Charles Krug Winery is a winery founded by Charles Krug in 1861. It was named to the National Register of Historic Places on November 8, 1974.

Beringer Vineyards is a large winery in St. Helena, California. Founded in 1876, Beringer Vineyards is "the oldest continuously operating winery in the Napa Valley", and is listed under both the National Register of Historic Places and as a California Historical Landmark. In 1934 it was the first California winery to offer public tours and wine tasting following the repeal of Prohibition. In 1939, Beringer invited attendees of the Golden Gate International Exposition to visit the winery; the winery also invited Hollywood stars including Clark Gable, Charles Laughton, and Carole Lombard to visit.

Rancho Carne Humana was a 17,962-acre (72.69 km2) Mexican land grant in present-day Napa County, California, given in 1841 by Governor Juan Alvarado to Edward Turner Bale. The name means "human flesh" in Spanish. There is speculation as to why the name was chosen. The grant was originally known to the native residents as "Huilic Noma" and also "Colijolmanoc". One naming theory speculates that Bale, in a bit of black humor, twisted "Colijolmanoc" into the similar-sounding Spanish "Carne Humana". Rancho Carne Humana was at the northern end of the Napa Valley, stretching from present-day Rutherford northward to Calistoga, ending at Tubbs Lane and including present-day St. Helena.

The J.C. Weinberger Winery, at 2849 St. Helena Hwy. in or near St. Helena, California, was listed on the National Register of Historic Places in 2015.It is now the William Cole Vineyards.It was started with construction of its two-and-a-half-story stone masonry building around 1876, which has a front gable plan, and is 63 by 41 feet (19 m × 12 m) in dimension. A two-story addition, 81 by 29 feet (24.7 m × 8.8 m) in plan, was attached around 1878. It is built of rough cut irregular coursed sandstone, 2 feet (0.61 m) thick.It was renovated in 1938 and in 2002.

The Saint Helena Southern Pacific Railroad Depot is a former train station in St. Helena, California.

Spottswoode Estate Vineyard & Winery is a winery in the southern outskirts of St. Helena, California, in the St. Helena AVA of the Napa Valley, in the United States. The estate was established in 1882. The winery is a producer of Cabernet Sauvignon and Sauvignon Blanc. As of 2021, about 40 acres are under cultivation, which typically produces around 5,000 cases of wine per year.

Freemark Abbey Winery, located between St. Helena and Calistoga in California's Napa Valley, traces its roots to 1886. Today, Freemark Abbey produces Cabernet Sauvignon, Merlot, Chardonnay, and Sauvignon Blanc, as well as very limited production wines, such as Viognier, Malbec, and Cabernet Franc. Depending on conditions, the winery sometimes makes a late harvest Riesling known as "Edelwein Gold".

Kosta Browne is a winery in Sebastopol, California, specializing in Pinot Noir. Kosta Browne was founded in 1997 and is currently owned by Duckhorn Wine Company.

Woodhouse Chocolate is an upscale chocolate shop in St. Helena, a city in Napa Valley, California. The shop is popular with celebrities such as Steven Spielberg. Founded by John Anderson, a former winemaker and graduate of Claremont McKenna College, and his wife chocolate chef Tracy Wood Anderson, a graduate of Scripps College. The store was inspired by the movie Chocolat.

St. Helena Catholic Church is a parish of the Roman Catholic Church in St. Helena, California. Founded in 1866 by Fr. Peter Deyaert, it remains an active congregation in the Diocese of Santa Rosa. The church, like the town and nearby Mount Saint Helena, is dedicated to St Helena of Constantinople. It is noted for its historic parish church located at Oak and Tainter Streets, the third such building used by the parish. Built from 1889 to 1890, the church was constructed with stone, a common building material among early settlers of the Napa Valley. The church was designed in an English Medieval style with a Gothic tower. The church was restored in 1945 after a fire burned its interior; during the renovations, the tower was also redesigned and two sacristies were added. The church is now the only remaining entirely stone church in Napa County.The church was added to the National Register of Historic Places on May 23, 1978.

The Restaurant at Meadowood was a Michelin Guide 3-star restaurant at the Meadowood Napa Valley resort in Napa Valley, California which specialized in local, sustainable California cuisine. The restaurant applied a "slightly more modern approach" with the use of emulsifiers, gelling agents and stabilizers.On September 28, 2020, The Restaurant at Meadowood was destroyed in the Glass Fire. In the immediate aftermath of the fire, the resort owners said they intend to ultimately rebuild the restaurant. Since the fire, the restaurant staff has been establishing temporary residencies and serving dinners at a few places around California and the United States, including the Ojai Valley Inn in Southern California.

Grace Episcopal Church is an Episcopal congregation in Saint Helena, California. It is part of the Episcopal Diocese of Northern California..