Dr. Milton Wedgewood House

The Dr. Louis J. Martel House is a historic house at 122–124 Bartlett Street in Lewiston, Maine. Built in 1883, it is a fine example of Queen Anne Victorian architecture executed in brick, and is historically notable as the home of Louis Martel, Maine's first Franco-American politician to achieve statewide prominence, and a major benefactor of the Lewiston community. The house was listed on the National Register of Historic Places in 1983.

The Agora Grand Event Center is a large event venue in Lewiston, Maine. It is also the second-tallest building in the state. The Agora Grand was created by renovating the former St. Patrick's Church, a Roman Catholic church whose cornerstone was laid on July 24, 1887, by the Right Reverend Bishop Healy and last Mass was held in October 2009. At 220 feet to its taller spire, it is the second-tallest building in Maine, based on the definition of "height to architectural top" by the Council on Tall Buildings and Urban Habitat.It was purchased in March 2014, by developer Andrew Knight, who opened the Agora Grand in May 2016. Knight received an award from the Lewiston Historic Preservation Board for his work in reviving the building; his wedding was the first held at the renovated building.In 2014, Knight converted the former St. Patrick's Church Rectory, also known as the Albert Kelsey Mansion, into a boutique hotel. The former church contains a mortuary chapel and basement crypt in which the church's original builder and priest, Monsignor Thomas Wallace, was buried from 1906 to 2007, when his body was exhumed and moved to Mt. Hope Cemetery. In 2015, Knight converted the former crypt into a novelty annex of the Inn at the Agora, purportedly the world's first "crypt hotel room."

The Healy Asylum is an historic building in Lewiston, Maine. It was built in 1893 as an orphanage for boys, a role it served until about 1970. It is now known as Healy Terrace, and is used for affordable senior housing. The building was added to the National Register of Historic Places in 1979, where it is listed as Healy Asylum. It was named for Msgr. James Augustine Healy, the bishop of the Roman Catholic Diocese of Portland at the time of its construction.

The Basilica of Saints Peter and Paul in Lewiston, Maine, also known as Ss. Peter and Paul Church, is a church which is a part of the Roman Catholic Diocese of Portland.

The Bradford House was an historic house in Lewiston, Maine, United States. The three-story brick building was built in 1876 and added to the National Register of Historic Places in 1978. It was extensively damaged by fire on July 4, 2007, and was later demolished. It was removed from the National Register in 2015.

Trinity Episcopal Church is an historic church building at 247 Bates Street in Lewiston, Maine. It is a modestly sized yet handsomely decorated Gothic Revival building, designed by C.C. Haight of New York City and completed in 1882. The building was listed on the National Register of Historic Places in 1978.

The Savings Bank Block is an historic commercial building at 215 Lisbon Street in downtown Lewiston, Maine. Built in 1870, it is a fine local example of commercial Second Empire architecture, and is representative of the city's early development as an industrial center. It was added to the National Register of Historic Places in 1978.

The Lewiston Main Post Office of Lewiston, Maine is located at 49 Ash Street in downtown Lewiston. Built in 1933 and enlarged in 1975, it is a fine local example of Colonial Revival architecture. The building was listed on the National Register of Historic Places in 1986 as U.S. Post Office–Lewiston Main.

Lewiston City Hall is located at 27 Pine Street (corner of Pine and Park Streets) in downtown Lewiston, Maine. Built in 1892, to a design by John Calvin Spofford, it is a distinctive regional example of Baroque Revival architecture. It is the city's second city hall, the first succumbing to fire in 1890. The building was listed on the National Register of Historic Places in 1976.

The Dingley Building, formerly the Oak Street School, is a historic municipal building at 36 Oak Street in Lewiston, Maine. Built in 1890, it is a distinctive local example of Richardsonian Romanesque architecture, designed by local architect George M. Coombs. It was added to the National Register of Historic Places in 1976. It now houses the Lewiston school system's administrative offices.

The First Callahan Building is an historic commercial and residential building at 276 Lisbon Street in Lewiston, Maine. Built in 1892 to a design by noted local architect George M. Coombs, the Renaissance Reviva brick building was part of a major development on the city's main commercial street by the Callahan brothers, owners of a local gentleman's furnishings store. The building was listed on the National Register of Historic Places in 1986.

The College Block/Lisbon Block is an historic commercial and civic building in Lewiston, Maine, United States. Built in 1855-56, it is the oldest surviving building in the city of the Franklin Company, the city's major early developer. The building has house many local civic groups, and served as Lewiston's town hall prior to its incorporation as a city in 1863. It was listed on the National Register of Historic Places in 1986.