Savings Bank Block

Lewiston City Hall is located at 27 Pine Street (corner of Pine and Park Streets) in downtown Lewiston, Maine. Built in 1892, to a design by John Calvin Spofford, it is a distinctive regional example of Baroque Revival architecture. It is the city's second city hall, the first succumbing to fire in 1890. The building was listed on the National Register of Historic Places in 1976.

The Lewiston Main Post Office of Lewiston, Maine is located at 49 Ash Street in downtown Lewiston. Built in 1933 and enlarged in 1975, it is a fine local example of Colonial Revival architecture. The building was listed on the National Register of Historic Places in 1986 as U.S. Post Office–Lewiston Main.

The First Callahan Building is an historic commercial and residential building at 276 Lisbon Street in Lewiston, Maine. Built in 1892 to a design by noted local architect George M. Coombs, the Renaissance Reviva brick building was part of a major development on the city's main commercial street by the Callahan brothers, owners of a local gentleman's furnishings store. The building was listed on the National Register of Historic Places in 1986.

The College Block/Lisbon Block is an historic commercial and civic building in Lewiston, Maine, United States. Built in 1855-56, it is the oldest surviving building in the city of the Franklin Company, the city's major early developer. The building has house many local civic groups, and served as Lewiston's town hall prior to its incorporation as a city in 1863. It was listed on the National Register of Historic Places in 1986.

The Atkinson Building is an historic commercial building at 220 Lisbon Street in Lewiston, Maine, United States. Erected in 1892, the six-story Romanesque style building was the tallest in the city at the time, and is still an imposing presence in the city's central business district. It was designed by Auburn architect Elmer I. Thomas to harmonize with the adjacent Lewiston City Hall (built 1890-92), and is one of its finest Victorian commercial buildings. It was listed on the National Register of Historic Places in 1983.

The Pilsbury Block is an historic commercial building at 200-210 Lisbon Street in Lewiston, Maine. The block was built in 1870, and is a late example of Italianate architecture, exhibiting some Romanesque details. The building was added to the National Register of Historic Places in 1983.

The Odd Fellows Block is a historic commercial building at 182-190 Lisbon Street in Lewiston, Maine. Built in 1876, it is an important early work of Lewiston architect George M. Coombs, then in partnership with William H. Stevens. It is a significant local example of commercial Victorian Gothic architecture, which typified Lewiston's downtown of the period. The building was listed on the National Register of Historic Places in 1986.

The Second Callahan Block is an historic commercial building at 282 Lisbon Street in downtown Lewiston, Maine. Built in 1909 to a design by Coombs & Gibbs, it was part of a major development by brothers Timothy and Eugene Callahan. It was added to the National Register of Historic Places in 1986. Although initially developed as a commercial property, it is presently used as housing.

The Bradford House was an historic house in Lewiston, Maine, United States. The three-story brick building was built in 1876 and added to the National Register of Historic Places in 1978. It was extensively damaged by fire on July 4, 2007, and was later demolished. It was removed from the National Register in 2015.

The Lower Lisbon Street Historic District encompasses part of the earliest commercial center of Lewiston, Maine. Located on the west side of Lisbon Street, the city's main commercial area, between Cedar and Chestnut Streets are a collection of commercial buildings representing a cross section of architectural styles, built between 1850 and 1950. When the historic district was listed on the National Register of Historic Places in 1985, it included 18 buildings. Eleven of these have since been demolished, and one has a significantly altered facade.

The Lewiston Mills and Water Power System Historic District encompasses the major 19th-century mill complexes and associated water power systems in Lewiston, Maine. Developed beginning in 1850, Lewiston's canals and mills were the largest textile mill complex in the state, and one of the best-preserved mature large-scale expressions of the Lowell system of cotton textile manufacturing, perfected at Waltham and Lowell, Massachusetts earlier in the 19th century. The district includes a series power canals and mill complexes developed over a 100-year period, along with mill worker housing and transportation infrastructure. It was listed on the National Register of Historic Places in 2015.

The Manufacturer's National Bank is an historic commercial building at 145 Lisbon Street Lewiston, Maine. Built in 1914, it was the tallest commercial building in Lewiston until 1950, and was one of the last major commercial buildings erected in the city before World War I, and one of the few that exhibits Classical Revival style. It was listed on the National Register of Historic Places in 1986.