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Klondike Hotel and Casino (also known as Klondike Inn) was a hotel and casino located on the Las Vegas Strip in Paradise, Nevada, in the United States. The property began as the Kona Kai Motel in 1962, and was purchased by Ralph Engelstad in 1969. The motel was sold to John Woodrum, who renamed it as the Klondike Inn in 1976. A casino was eventually added, and the Klondike became popular among local residents. In 2005, the Klondike was sold to Royal Palm Las Vegas, which planned to replace it with a casino and condo hotel resort known as Paramount Las Vegas. The Klondike closed in June 2006, and was demolished in March 2008. Royal Palm Las Vegas had difficulty obtaining financing for the Paramount project, and the land was put up for sale later in 2008. A Harley-Davidson dealership opened on the former Klondike property in 2014. The hotel sat on 5.29 acres (2.14 ha) of land on Las Vegas Boulevard, between the Welcome to Fabulous Las Vegas sign and McCarran International Airport. The Klondike was the southernmost hotel on the Las Vegas Strip until its closure. Mandalay Bay is now the southernmost hotel. Woodrum also operated a sister property, the Klondike Sunset Casino, in nearby Henderson, from 1999 until his death in 2014.

Dream Las Vegas is a boutique hotel and casino under construction on the southern Las Vegas Strip in Paradise, Nevada. It is being developed by Shopoff Realty Investments and the real estate firm Contour. Dream Las Vegas was announced in February 2020, and construction was expected to begin within a year. However, the project was delayed after the Transportation Security Administration raised numerous safety concerns, regarding its proximity with Harry Reid International Airport. The project underwent numerous design changes, and received county approval in October 2021. Construction began on July 8, 2022, with completion expected at the end of 2024. The project is expected to cost $550 million. The 20-story hotel will include 531 rooms and will be managed by Dream Hotel Group, serving as the company's flagship location.

Little Church of the West is a wedding chapel on the Las Vegas Strip in Paradise, Nevada, that is listed on the United States National Register of Historic Places. Built of redwood, it was intended to be a replica of a typical pioneer town church. It is the oldest building on the Las Vegas Strip.

Glass Pool Inn was a motel located on the Las Vegas Strip in Paradise, Nevada. It initially opened as the Mirage Motel in 1952. An above-ground swimming pool was added in 1955, and included large porthole windows that allowed outsiders to peer inside. The motel became well known for its pool, which was used in numerous films and television shows, as well as music videos and photo shoots. In 1988, the Mirage Motel was renamed as the Glass Pool Inn to avoid confusion with Steve Wynn's new Mirage resort, also located on the Las Vegas Strip. The Glass Pool Inn was closed in September 2003, and demolished a year later for a project that ultimately did not materialize.

The Shark Reef Aquarium at Mandalay Bay is a public aquarium located at and owned by the Mandalay Bay Resort and Casino in Las Vegas, Nevada. Its main tank is 1,300,000 US gallons (4,900,000 l), one of the largest in North America. The facility is 95,000 sq ft (8,800 m2), and displays numerous species of sharks, rays, fish, reptiles, and marine invertebrates. It also features a shark tunnel. The reef was developed in consultation with the Vancouver Aquarium.

Mandalay Bay is a 43-story luxury resort and casino on the Las Vegas Strip in Paradise, Nevada. It is owned by MGM Growth Properties and The Blackstone Group and operated by MGM Resorts International. One of the property's towers operates as the Delano; the Four Seasons Hotel is independently operated within the Mandalay Bay tower, occupying five floors (35–39). Mandalay Bay has 3,209 hotel rooms, 24 elevators and a casino of 135,000 square feet (12,500 m2). Adjacent to the hotel is the 2-million-square-foot (190,000 m2) Mandalay Bay Convention Center and the 12,000-seat Michelob Ultra Arena. The Mandalay Bay Tram connects the resort to its sister properties, Excalibur and Luxor, all three of which were constructed by Circus Circus Enterprises before its sale to MGM.

The Michelob Ultra Arena, formerly known as the Mandalay Bay Events Center, is a 12,000-seat indoor arena at the Mandalay Bay Resort and Casino, on the Las Vegas Strip, in Paradise, Nevada. It is owned and operated by MGM Resorts International and is the home arena for the Las Vegas Aces of the Women's National Basketball Association. In 2022, it will also be home to the Las Vegas Desert Dogs of the National Lacrosse League. The arena also hosts a variety of music, sports, and entertainment events. In 2021, MGM Resorts and Anheuser-Busch entered a naming-rights agreement for the arena to be named after Michelob Ultra.

Red Square was a Russian-themed restaurant and bar located in the Mandalay Bay Resort in Las Vegas, Nevada and at the Tropicana Atlantic City in Atlantic City, New Jersey. The Atlantic City location closed in 2012, followed by the Las Vegas restaurant closing in November 2019, after twenty years of service.

The Skyvue Las Vegas Super Wheel (also capitalized SkyVue) is an unfinished giant Ferris wheel near the Mandalay Bay Hotel and Casino on the Las Vegas Strip in Paradise, Nevada, US. As of 2019, only the concrete pillars have been built. Construction of the wheel and the proposed larger 3-phase project for the site — London, Las Vegas — have been abandoned, and the plot has been advertised for sale.London, Las Vegas, as suggested by the official website, was to be a 38.5-acre property featuring 1,300 hotel rooms, a casino, the Skyvue wheel and 550,000 square feet of restaurants and shops—all of which would be architectural replicas of various British landmarks and neighborhoods.The Skyvue wheel, being "Phase I of London, Las Vegas" was intended to feature a large display billed as the "largest outdoor advertising LED screen in the world".

Rumjungle was a popular Las Vegas restaurant and nightclub built as a part of the Mandalay Bay Resort and Casino original construction. It consistently made the Nightclub & Bar Magazine list of the Top 100 nightclubs in the United States, and was in the Top 20 of Restaurant & Institutions Top 100 Grossing Restaurants in the United States.It was the largest Brazilian (Churrascaria style) restaurant in the world, and had the largest rum list in the world; its rum bar was 144 feet long and 19 feet high.Rumjungle filed for bankruptcy in March 2010 and has since closed.

Delano Las Vegas (formerly known as THEhotel) is a 43-story 1,117-room luxury suite hotel. It is owned and operated by MGM Resorts International. It is located within the Mandalay Bay complex on the Las Vegas Strip in Paradise, Nevada. It opened on December 17, 2003, as "THEhotel at Mandalay Bay." In 2012, owner MGM Resorts International announced a partnership with Morgans Hotel Group to rebrand the hotel as Delano Las Vegas. Construction to rebrand the hotel began in April 2014. Several floors were worked on at a time, allowing much of the hotel to remain open during renovations. The Delano held its grand opening ceremonies in September 2014. The hotel includes an Alain Ducasse restaurant called "Rivea" and a lounge called "Skyfall", both located at the top of the hotel.

On October 1, 2017, Stephen Paddock, a 64-year-old man from Mesquite, Nevada, opened fire on the crowd attending the Route 91 Harvest music festival on the Las Vegas Strip in Nevada. From his 32nd-floor suites in the Mandalay Bay hotel, he fired more than 1,000 bullets, killing 60 people and wounding 411 with the ensuing panic bringing the number of injured to 867. About an hour later, Paddock was found dead in his room from a self-inflicted gunshot wound. His motive is officially undetermined. The incident is the deadliest mass shooting committed by an individual in United States history. It focused attention on firearms laws in the U.S., particularly with regard to bump stocks, which Paddock used to fire shots in rapid succession, at a rate similar to that of automatic firearms. Bump stocks were banned by the U.S. Justice Department in December 2018.