Le Cordon Bleu College of Culinary Arts in Boston

East Cambridge is a neighborhood of Cambridge, Massachusetts. Referred to in modern times as Area 1, East Cambridge is bounded by the Charles River and the Charlestown neighborhood of Boston on the east, the Somerville border on the north, Broadway and Main Street on the south, and the railroad tracks on the west. Most of the streets form a grid aligned with Cambridge Street, which was laid out to directly connect what is now the Charles River Dam Bridge with what in 1809 was the heart of Cambridge, Harvard Square. The northern part of the grid is a roughly six by eight block residential area. Cambridge Street itself is retail commercial, along with Monsignor O'Brien Highway, the Twin Cities Plaza strip mall, and the enclosed Cambridgeside Galleria. Lechmere Square is the transportation hub for the northern side. The southern half of the grid is largely office and laboratory space for hundreds of dot-com companies, research labs and startups associated with MIT, biotechnology firms including Genzyme, Biogen and Moderna, the Athenaeum Press Building, light industry, an NRG Energy power station (formerly Mirant Kendall), and various small businesses. This half of the neighborhood is generally identified with Kendall Square. Along the waterfront are several hotels and taller apartment buildings.

The building at 42 Edward J. Lopez Avenue is a rare Federal period house in East Cambridge, Massachusetts. The two story wood-frame building has a hip roof and very simple styling. It was built about 1830, during the first period of East Cambridge's development after construction of the West Boston Bridge, and was moved to its present location c. 1900, probably as part of construction work in the area. The nature of the terrain in the area at that time means it cannot have been moved very far.The house was listed on the National Register of Historic Places in 1982.

The American Net and Twine Company Factory is a historic factory at 155 2nd Street in Cambridge, Massachusetts. It was built in 1875 by the nation's first manufacturer of cotton fishing nets. It now houses corporate office space. It was listed on the National Register of Historic Places in 1982.

The Bottle House Block is a brick rowhouse in Cambridge, Massachusetts. It was built in 1826 as a tavern by Deming Jarves, owner of the New England Glass Company, and was identified as the "Bottle House Block" from its earliest days. The building is the third oldest in East Cambridge and one of a few surviving brick buildings in Cambridge from that period. At the time of its construction it stood on the main road from the West Boston Bridge to Old Cambridge (roughly Harvard Square).The building was listed on the National Register of Historic Places in 1982.

Athenæum Press is an historic building located at 215 First Street in Cambridge, Massachusetts. The structure occupies the entire block between First Street, Second Street, Athenæum Street, and Linskey Way, which was formerly known as Munroe Street. Topped by a statue of Athena sculpted by Adio diBiccari, the building is visible from the nearby Charles River and the Longfellow Bridge.

The Middlesex County Courthouse is a historic courthouse building in East Cambridge, Massachusetts. It was initially designed in 1814-1816 by noted architect Charles Bulfinch (1763–1844), and subsequently enlarged in 1848 by Ammi B. Young. The original courthouse was given by Andrew Craigie as part of his scheme to develop East Cambridge. Bulfinch created its plans, and it was erected 1814-1816 on Third Street between Otis and Thorndike Streets. His original stuccoed building is now known by only one surviving sketch, and forms the central core of today's building. In 1848 architect Young enlarged and refaced the building in brick, adding late Federal and Greek Revival details such as a monumental cupola, Palladian windows, and recessed wall arches. A later 1924 addition obscured his 1848 entry facade. In 1973 the buildings were slated for demolition to make a parking lot, but saved by a preservation effort led by architect Graham Gund. Restoration efforts removed the 1924 addition, recreated Young's entry portico, restored its large clock tower, and cleaned and repaired the cupola's gold dome, brickwork, cast-iron trim, wrought-iron fencing, and slate and copper roofs. Other buildings in the restored Bulfinch Square include the imposing Registry of Deeds and Probate Court (1896) with its four giant brick-columned porticoes, the Clerk of Courts Building (1889), and the Third District Court Built (1931, architect Charles Greco). The Middlesex County Courthouse building is situated adjacent to the iconic 16 story former Edward J. Sullivan "Hi-rise" Superior court building.

CambridgeSide (previously CambridgeSide Galleria) is an enclosed shopping mall in Cambridge, Massachusetts that opened in 1990. As of 2021, the mall is anchored by Best Buy and TJ Maxx. Previous anchors include department stores Filene's, Lechmere, Macy's, Macy's Home and Children's, and Sears.

The East Cambridge Historic District encompasses the historic center of East Cambridge, Massachusetts. It includes the major buildings that were built to house county services for Middlesex County beginning in the 1810s, and a cluster of largely vernacular Greek Revival worker housing located west of the county complex on Otis, Thorndike, Spring, and Sciarappa Streets. The district was listed on the National Register of Historic Places in 1983.

The MIT Center for Information Systems Research (CISR) is a research center at the MIT Sloan School of Management founded in 1974. MIT CISR's research focuses on the use of information technology and management in complex organizations. Its mission is to "develop concepts and frameworks to help executives address the IT-related challenges of leading increasingly dynamic, global, and information-intensive organizations."The Center for Information Systems Research has done groundbreaking research in the areas of managerial computing, executive support systems, critical success factors, IT governance, IT portfolio management, operating model, and enterprise architecture.

The Rowland Institute for Science was founded by Edwin H. Land, founder of Polaroid Corporation, as a nonprofit, privately endowed basic research organization in 1980. The institute merged with Harvard University on July 1, 2002, and is now called The Rowland Institute at Harvard. The Rowland Institute is dedicated to experimental science across a wide range of disciplines. Research subjects at the institute includes chemistry, physics and biology, and focus on interdisciplinary work and the development of new experimental tools. It is located on the Charles River near Kendall Square in Cambridge, Massachusetts, and is a few miles away from the main campus of Harvard.

The Kendall Cogeneration Station is a power station owned by Vicinity Energy that produces both steam and power for the cities of Boston and Cambridge. Owned by GenOn Energy in 2012, in 2013 Veolia Energy North America purchased the plant from NRG Energy. In 2020, Antin Infrastructure Partners acquired Veolia Energy North America and renamed it Vicinity Energy.

East Cambridge Savings Bank is a mutual savings bank in Massachusetts. Its branches serve communities north and west of Boston, Massachusetts. It was founded in 1854. The bank's Art Deco headquarters building at 292 Cambridge Street in East Cambridge, Massachusetts was built in 1931 to a design by T. M. James. It has a triple-arched front facade, an element repeated on the side with three similarly-scaled round-arch windows. Bands of carving adorn an entablature band at the top of the main wall, and on a stepped back section above. The building's interior includes sculpture by Paul Fjelde and murals painted by Alfred Rasmussen. The building was listed on the National Register of Historic Places in 1982.