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NYU Langone Hospital – Brooklyn is a full-service, 450-bed academic teaching hospital in the Sunset Park neighborhood of Brooklyn, New York City. Formerly named NYU Lutheran Medical Center, it functions as the hub of Lutheran Healthcare, which itself is part of the larger NYU Langone Health. Many of Lutheran's staff members are bilingual/bicultural, speaking languages such as Spanish, Chinese, Arabic, and Russian, reflecting the diversity of Sunset Park. The hospital offers a range of clinical programs, including a New York State designated Stroke Center, Regional Trauma Center, interventional and therapeutic cardiac catheterization laboratory, orthopedics and a Bariatric Center of Excellence. It treated 75,808 patients in 2011, and has one of the busiest emergency departments in Brooklyn, treating approximately 80,000 patients a year.

The Brooklyn Army Terminal (BAT) is a large warehouse complex in Sunset Park, Brooklyn, New York City. The site occupies more than 95 acres (38 ha) between 58th and 63rd Streets west of Second Avenue, on Brooklyn's western shore. The complex was originally used as a United States Army Supply Terminal called the Brooklyn Army Base or Brooklyn Army Supply Base. It is now used for commercial and light industrial purposes, and also serves a NYC Ferry stop. The Brooklyn Army Terminal was designed by Cass Gilbert. It contains two warehouses, three piers, several smaller administrative buildings, and rail sidings for loading cargo. When built, the warehouses were among the world's largest concrete structures. The Brooklyn Army Terminal adjoins the former Bush Terminal, which was used by the United States Navy. The Brooklyn Army Terminal's construction was originally approved in 1918, during World War I, and was completed the following year after the conclusion of the war. The terminal was subsequently leased out and used for various purposes, including as a dock, a military prison, and a storage space for drugs and alcohol during Prohibition. During World War II, the terminal was the United States' largest military supply base. The United States Army stopped using the Brooklyn Army Terminal in 1967, and the terminal was briefly used by the United States Postal Service and the Navy. The New York City government purchased the terminal in 1981, and it was listed on the National Register of Historic Places in 1983. Since then, the Brooklyn Army Terminal has undergone a series of renovations to make it suitable for commercial and light industrial use.

58th Street was the penultimate station on the demolished section of the BMT Fifth Avenue Line in Brooklyn, New York City. It was served by trains of the BMT Fifth Avenue Line, and had two tracks and one island platform. The station was built on October 1, 1893. The next stop to the north was 52nd Street. The next stop to the south was the 65th Street Terminal. It closed on May 31, 1940. Current rapid transit service in this area can be found one block east and then another block south at the 59th Street station on the underground BMT Fourth Avenue Line and BMT Sea Beach Line.

The 65th Street Yard, also Bay Ridge Rail Yard, is a rail yard on the Upper New York Bay in Sunset Park and Bay Ridge, Brooklyn. Equipped with two transfer bridges which allow rail cars to be loaded and unloaded onto car floats, the last of once extensive car float operations in the Port of New York and New Jersey. Located adjacent to the Brooklyn Army Terminal, it provided a major link in the city's rail freight network in the first half of the twentieth century. It was later used as a conventional railroad yard at the end of the LIRR/NY&A Bay Ridge Branch. The new transfer bridges were constructed in 1999, but remained unused until the transfer bridges were activated in July 2012.

52nd Street was a station on the demolished section of the BMT Fifth Avenue Line in Brooklyn, New York City. It was served by trains of the BMT Fifth Avenue Line, it had 2 tracks and 1 island platform. The station was opened on October 1, 1893, at the intersection of Third Avenue and 52nd Street. The next stop to the north was 46th Street. The next stop to the south was 58th Street. It closed on May 31, 1940. Current rapid transit service in this area can be found one block east and then another block south at the 53rd Street station on the underground BMT Fourth Avenue Line.

Sister Elizabeth Memorial Hospital was a hospital in the Sunset Park neighborhood of Brooklyn, New York. It was located at 362 51st Street, between Third Avenue and Fourth Avenue and was absorbed by Lutheran Medical Center during the 1980s.

The 65th Street Terminal station was a station on the demolished section of the BMT Fifth Avenue Line in Brooklyn, New York City. It was served by trains of the BMT Fifth Avenue Line, and despite the name of the line was actually located at Third Avenue and 65th Street. It had two tracks and one island platform. The station had connections to the Bay Ridge Suburban Line, Bay Ridge Line, Third Avenue Line, and 86th Street Suburban Line trolleys. Today, the western terminus of the Belt Parkway at the interchange with the Gowanus Expressway can be found in the vicinity.

The 59th Street station is an express station on the BMT Fourth Avenue Line of the New York City Subway. Located at 59th Street and Fourth Avenue in Sunset Park, Brooklyn, it is served by the N and R trains at all times. During rush hours, several W and northbound Q trains also serve the station.The 59th Street station was constructed as part of the Fourth Avenue Line, which was approved in 1905. Construction on the segment of the line that includes 59th Street started on March 15, 1913, and was completed in 1915. The station opened on June 22, 1915, as the southernmost station of the initial portion of the BMT Fourth Avenue Line. The station's platforms were lengthened in 1926–1927, and again during the 1960s. Elevator access was added in late 2020, in tandem with a station renovation between 2018 and 2020 to make the station compliant with the Americans with Disabilities Act of 1990.

On the morning of April 12, 2022, a mass shooting was committed on a northbound N train on the New York City Subway in Sunset Park, Brooklyn, New York, United States. At approximately 8:24 a.m. EDT, a man reported to be 62-year-old Black nationalist Frank Robert James put on a gas mask, threw two smoke grenades, and fired a handgun 33 times. The shooting occurred as the train was traveling between the 59th Street and 36th Street stations. Twenty-nine people were injured, ten of them from direct gunfire; the remaining injuries were from smoke inhalation. Most passengers disembarked at 36th Street, where some passengers fled onto an R train that traveled one additional stop to 25th Street. On the day after the attack, Frank James was arrested as the suspect after a large manhunt. James was charged by the U.S. Attorney's Office for the Eastern District of New York with committing a terrorist act on a mass transit system and discharging a firearm during the commission of a Crime of Violence, to which James pleaded not guilty. On January 3, 2023, James pled guilty to federal terrorism charges.

Millennium Skate Park, also known as Owl's Head Skate Park, is a skate park in Bay Ridge, Brooklyn, located in Owl's Head Park, adjacent to the Sunset Park Greenway.

The 53rd Street station is a local station on the BMT Fourth Avenue Line of the New York City Subway. Located at 53rd Street and Fourth Avenue in Sunset Park, Brooklyn, it is served by the R train at all times. The N train also stops here during late nights, and some rush-hour W trains stop here in the peak direction. The 53rd Street station was constructed as part of the Fourth Avenue Line, which was approved in 1905. Construction on the segment of the line that includes 53rd Street started on March 15, 1913, and was completed in 1915. The station opened on September 22, 1915, after the opening of the initial portion of the BMT Fourth Avenue Line to 59th Street. The station's platforms were lengthened in 1926–1927, and again during a renovation in 1968–1970. The station was renovated again in 2017.

Sunset Park is a neighborhood in the southwestern part of the borough of Brooklyn in New York City, bounded by Park Slope and Green-Wood Cemetery to the north, Borough Park to the east, Bay Ridge to the south, and Upper New York Bay to the west. The neighborhood is named after a 24.5-acre (9.9 ha) public park of the same name, located between 41st and 44th Streets and Fifth and Seventh Avenues. The region north of 36th Street is also known as Greenwood Heights or South Slope. The area was initially occupied by the Canarsee Indians until the first European settlement occurred in 1636. Through the late 19th century, Sunset Park was sparsely developed, and it was considered to be part of Bay Ridge or South Brooklyn. The arrival of elevated railways and the subway led to Sunset Park's development, with many middle-class row houses and several industrial hubs being erected in the 1890s through the 1920s. After the decline of the industrial hubs in the 1940s and 1950s, the name "Sunset Park" was given to the region north of 65th Street as part of an urban renewal initiative. Immigrant groups started moving to the neighborhood in the late 20th century due to its relative affordability, and the neighborhood's population was primarily composed of Hispanics, Chinese and Indians (along with less perceptible swaths of predominantly white young urban professionals and the remaining vestiges of earlier, working class Scandinavian, Irish and Italian communities) by the 21st century. Sunset Park is part of Brooklyn Community District 7. It is patrolled by the 72nd Precinct of the New York City Police Department. Fire services are provided by the New York City Fire Department's Engine Company 201 and Engine Company 228/Ladder Company 114. Politically, Sunset Park is represented by the New York City Council's 38th and 39th Districts.