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Portland Street is a street in Manchester, England, which runs from Piccadilly at its junction with Newton Street south-westwards to Oxford Street at its junction with Chepstow Street. The major buildings of Portland Street include the largest former warehouse in the city centre, Watts Warehouse (grade II* listed), the former Bank of England Building and other former warehouses on the corners of Princess Street.

Guardian Exchange was an underground telephone exchange built in Manchester from 1954 to 1957. It was built together with the Anchor exchange in Birmingham and the Kingsway exchange in London – all believed to provide hardened communications in the event of nuclear war; as well as linking the UK government in London to the US Government in Washington, D.C. by means of a secure and hardened transatlantic telephone cable making landfall near Oban and running through Glasgow, Manchester and Birmingham. Today, the underground site is used for telephone cabling. Constructed at a depth of below 35 metres (115 ft), the tunnels are about 2 metres (80 in) in diameter. The exchange cost around £4 million (approximately £126 million in 2015 prices), part of which was funded by the United Kingdom's NATO partners.

The Circus Tavern in Portland Street, Manchester, England, is the smallest public house in the city, with one of the smallest bars in the country. Built in about 1790, it is also one of the oldest pubs in Manchester, although it only became a pub in about 1840. The pub is owned by Tetley's, a Yorkshire brewery, and contains photographs of former Manchester United players who frequented the pub, including George Best. It was listed as a Grade II building in 1994.

St James Buildings is a high-rise, Grade II listed building on Oxford Street, Manchester, England, completed in 1912. The building was constructed in the Edwardian Baroque style and has a Portland stone exterior reaching a maximum height of 60m.

Cruz 101 (better known simply as Cruz) is a nightclub and music venue situated in Manchester's Gay Village which is centred on Canal Street, England. It is one of the most popular and longest-running gay clubs in Greater Manchester, often boasting itself as "Manchester's Favourite Gay Venue".

Rafters, later known as Jilly's, was a nightclub located in St. James Buildings, Oxford Street, Manchester, England. Some well-known bands played concerts at Rafters in the 1970s and 1980s. Rob Gretton, who went on to become the manager of Joy Division, worked at Rafters. It featured in the 2007 film Control. The Depeche Mode albums An Futurist Night and A Second Now in Manchester were recorded at Rafters in 1981. A Second Now In Manchester was released on CD on Vertigo Records in 1990.

The Peveril of the Peak is a historic public house in Manchester, England. The Campaign for Real Ale considers it to have an "interior of exceptional national historic importance."

The Mechanics' Institute, 103 Princess Street, Manchester, is notable as the building in which three significant British institutions were founded: the Trades Union Congress (TUC), the Co-operative Insurance Society (CIS) and the University of Manchester Institute of Science and Technology (UMIST). In the 1960s it was occupied by the Manchester College of Commerce. It has been a Grade II* listed building since 11 May 1972.

55 Faulkner Street (also 18 Nicholas Street) is a historic building in the Chinatown district of Manchester, United Kingdom. Constructed in 1870, and Grade II listed in June 1994, it caught fire and was gutted in November 2016.

The Palace Theatre, Manchester, is one of the main theatres in Manchester, England. It is situated on Oxford Street, on the north-east corner of the intersection with Whitworth Street. The Palace and its sister theatre the Opera House on Quay Street are operated by the same parent company, Ambassador Theatre Group. The original capacity of 3,675 has been reduced to its current 1,955.

The Odeon Cinema, Manchester (originally known as the Paramount Theatre or the Paramount Cinema) was a former Odeon Cinema located on Oxford Street, Manchester, England. It was close to St. Peter's Square, within the Civic Quarter of Manchester city centre. It was demolished in April 2017, and replaced by Landmark, a 14-storey office building, as part of a major transformation of the area.

Princess Street is one of the main streets in the city centre of Manchester, England. It begins at Cross Street and runs approximately eastwards across Mosley Street, Portland Street and Whitworth Street until the point where it continues as Brook Street and eventually joins the A34.