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Plaza Centro Mall is an enclosed shopping mall located in Caguas, Puerto Rico. The mall opened in 1986, and is currently anchored by a JCPenney, Sam's Club, Costco, and Burlington. It also has other major tenants such as a Party City, OfficeMax, Planet Fitness, Chuck E. Cheese, and a PetSmart. It was formerly anchored by a Kmart in its original shopping center portion which closed in 2020. The mall is divided in two portions, Plaza Centro I which opened in 1986 as an outdoor shopping center, and Plaza Centro II which opened between 1999 and 2000 as the enclosed mall portion.

The Logia Unión y Ampara No. 44, or Logia Masónica de Caguas is a masonic lodge located in Caguas, Puerto Rico which was built in 1923 and listed in the National Register of Historic Places on June 15, 1988.

The Aguayo Aldea Vocational High School (Spanish: Escuela Superior Vocacional Aguayo Aldea), popularly known as La Vocacional, is a historic school in Caguas, Puerto Rico, named after Nicolás Aguayo Aldea, a Puerto Rican writer and politician from the 19th century. The Art Deco building dates to 1939 and was designed by architects Lizardi & Díaz Diez. Although originally an elementary and intermediary school, La Vocacional became a high school in 1960. The school building was added to the National Register of Historic Places on August 4, 1987, and it still functions as a vocational school.

Primera Iglesia Bautista de Caguas, or Caguas’ First Baptist Church, was built in 1909. It was listed on the National Register of Historic Places in 2008.The church was founded in 1900.The church is notable as a "beautiful example of Romanesque Revival architecture."

Caguas Pueblo is a barrio and downtown area that serves the administrative center (seat) of the city and municipality of Caguas, a municipality of Puerto Rico. It is bordered by the Cagüitas River to the north and located two miles southwest of the Río Grande de Loíza. Its population in 2020 was 20,008.As was customary in Spain, in Puerto Rico, the municipality has a barrio called pueblo (barrio-pueblo starting with the 1990 US Census) which contains a central plaza or main town square, the municipal buildings (such as the city hall), and a Catholic church. Fiestas patronales (patron saint festivals) are held in the main town square every year. The municipal and mayoral offices were located in the City Hall building at the western edge of the main town square until 2010 when a new City Hall building located in the northwestern side of the downtown area was inaugurated.

The Cagüitas River (Spanish: Río Cagüitas) is a river of Caguas and Aguas Buenas, Puerto Rico.

Cathedral Dulce Nombre de Jesús, or in English, Sweet Name of Jesus Cathedral, is a cathedral of the Catholic Church in Caguas, Puerto Rico. It is located on the Plaza Palmer in the center of town, and next to the Colegio Católico Notre Dame Elementary. There are only five cathedrals in Puerto Rico and Cathedral Dulce Nombre de Jesús is the seat of the Diocese of Caguas. The patron saint of the church, as well as that of the city, is the Dulce Nombre de Jesús (Sweet Name of Jesus).

The Diocese of Caguas (Latin: Dioecesis Caguana) is a Latin Church ecclesiastical territory, or diocese, of the Catholic Church in southeastern Puerto Rico in the United States. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of San Juan de Puerto Rico The mother church of the Diocese of Caguas is the Catedral Dulce Nombre de Jesús (Cathedral of the Sweet Name of Jesus) in Caguas. As of 2023, the current bishop of Cagus is Eusebio Ramos Morales. The diocese was erected on November 4, 1964

The Caguas City Hall (Spanish: Casa de la Alcaldía de Caguas) consists of two buildings located in the downtown area of Caguas, Puerto Rico.

The Caguas Museum of Art (Spanish: Museo de Arte de Caguas) is an art museum in Caguas Pueblo, the downtown and administrative district of the municipality of Caguas, Puerto Rico. The first level of the museum is dedicated to Caguas native painter Carlos Osorio and the second level offers temporary exhibitions. The entrance is free and guided tours are available. The museum also host cultural events.

The Caguas Museum of History (Spanish: Museo de Historia de Caguas, also often referred to as Museo de Caguas) is a history museum located in the old city hall of the municipality of Caguas, Puerto Rico. This building is located on Muñoz Rivera Street on the western edge of Plaza Palmer, the main town square. Caguas Pueblo, which is the historic and administrative center of the municipality. The museum consists of five exhibitions each dedicated to either a historical era or a particular aspect of the Puerto Rican and local Criollo identity and history. The term Criollo, outside of its historical connotations, is often used to describe natives and residents of the city of Caguas regardless of race or ethnicity. The term comes from one of the city's nicknames: la Ciudad Criolla ('Criollo city'), which also lends the term to numerous local sports teams.

The Ana G. Méndez University (UAGM / AGMU) is a private university system with its main campus in San Juan, Puerto Rico that participates in the Puerto Rico Space Grant Consortium.