Logia Unión y Amparo No. 44

Primera Iglesia Bautista de Caguas, or Caguas’ First Baptist Church, was built in 1909. It was listed on the National Register of Historic Places in 2008.The church was founded in 1900.The church is notable as a "beautiful example of Romanesque Revival architecture."

Cathedral Dulce Nombre de Jesús, or in English, Sweet Name of Jesus Cathedral, is a cathedral of the Catholic Church in Caguas, Puerto Rico. It is located on the Plaza Palmer in the center of town, and next to the Colegio Católico Notre Dame Elementary. There are only five cathedrals in Puerto Rico and Cathedral Dulce Nombre de Jesús is the seat of the Diocese of Caguas. The patron saint of the church, as well as that of the city, is the Dulce Nombre de Jesús (Sweet Name of Jesus).

The Diocese of Caguas (Latin: Dioecesis Caguana) is a Latin Church ecclesiastical territory, or diocese, of the Catholic Church in southeastern Puerto Rico in the United States. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of San Juan de Puerto Rico The mother church of the Diocese of Caguas is the Catedral Dulce Nombre de Jesús (Cathedral of the Sweet Name of Jesus) in Caguas. As of 2023, the current bishop of Cagus is Eusebio Ramos Morales. The diocese was erected on November 4, 1964

The Caguas Museum of Art (Spanish: Museo de Arte de Caguas) is an art museum in Caguas Pueblo, the downtown and administrative district of the municipality of Caguas, Puerto Rico. The first level of the museum is dedicated to Caguas native painter Carlos Osorio and the second level offers temporary exhibitions. The entrance is free and guided tours are available. The museum also host cultural events.

The Caguas Museum of History (Spanish: Museo de Historia de Caguas, also often referred to as Museo de Caguas) is a history museum located in the old city hall of the municipality of Caguas, Puerto Rico. This building is located on Muñoz Rivera Street on the western edge of Plaza Palmer, the main town square. Caguas Pueblo, which is the historic and administrative center of the municipality. The museum consists of five exhibitions each dedicated to either a historical era or a particular aspect of the Puerto Rican and local Criollo identity and history. The term Criollo, outside of its historical connotations, is often used to describe natives and residents of the city of Caguas regardless of race or ethnicity. The term comes from one of the city's nicknames: la Ciudad Criolla ('Criollo city'), which also lends the term to numerous local sports teams.

The Caguas City Hall (Spanish: Casa de la Alcaldía de Caguas) consists of two buildings located in the downtown area of Caguas, Puerto Rico.

Caguas Pueblo is a barrio and downtown area that serves the administrative center (seat) of the city and municipality of Caguas, a municipality of Puerto Rico. It is bordered by the Cagüitas River to the north and located two miles southwest of the Río Grande de Loíza. Its population in 2020 was 20,008.As was customary in Spain, in Puerto Rico, the municipality has a barrio called pueblo (barrio-pueblo starting with the 1990 US Census) which contains a central plaza or main town square, the municipal buildings (such as the city hall), and a Catholic church. Fiestas patronales (patron saint festivals) are held in the main town square every year. The municipal and mayoral offices were located in the City Hall building at the western edge of the main town square until 2010 when a new City Hall building located in the northwestern side of the downtown area was inaugurated.

The Caguas Museum of Folk Arts (Spanish: Museo de Artes Populares de Caguas) is an art museum located in Caguas Pueblo, the downtown and administrative area of the municipality of Caguas, Puerto Rico. The museum is dedicated to Puerto Rican and Criollo artists, traditional handmade products, and local arts and crafts. The museum is divided into two areas: the first area is a permanent exhibition that showcases Puerto Rican master craftsmen and artists such as Zoilo Cajigas, Celestino Avilés, and Domingo Orta. The second area has a selective sample of eight miniature pieces by Caguas master artisan, Edwin Báez, as well as quarterly temporary exhibitions.

The Caguas Museum of Tobacco (Spanish: Museo del Tabaco de Caguas), officially the Herminio Torres Grillo Museum of Tobacco, is a museum dedicated to the history of the growth and industry of tobacco in Puerto Rico and the wider region of the Caribbean. This museum is located on an old colonial neoclassical building in Caguas Pueblo (downtown Caguas) which used to be a blacksmith shop, and it is the only of its kind in Puerto Rico. Tobacco used to be one of the most important crops in Puerto Rico until the 1960s, and Caguas used to be one of the main growers of this crop in the island.The museum contains relics from the former industry and replicas of a "tobacco ranchón", used to cure and dry tobacco leaves for the confection of cigars. The museum also hosts experienced cigarmaking artisans who sell their product on site.

The Aguayo Aldea Vocational High School (Spanish: Escuela Superior Vocacional Aguayo Aldea), popularly known as La Vocacional, is a historic school in Caguas, Puerto Rico, named after Nicolás Aguayo Aldea, a Puerto Rican writer and politician from the 19th century. The Art Deco building dates to 1939 and was designed by architects Lizardi & Díaz Diez. Although originally an elementary and intermediary school, La Vocacional became a high school in 1960. The school building was added to the National Register of Historic Places on August 4, 1987, and it still functions as a vocational school.

Shops at Caguas, formerly known as Las Catalinas Mall, is an enclosed shopping mall located in Caguas, Puerto Rico, United States. The mall opened in 1997, and is currently anchored by a Sector Sixty6 entertainment center which took up space of a vacant Kmart, one of the original anchor tenants of the mall. A former original anchor tenant, Sears, closed their store in February 2021, the anchor space has sat vacant since the closure of the store. The mall is home to the first "Large Premium Format" movie theater in Puerto Rico and second in the Caribbean region at the time of its opening, which is owned and managed by Caribbean Cinemas.

The Gautier Benitez High School, a school named after Puerto Rican poet José Gautier Benítez, was built in 1924 in Caguas, Puerto Rico and is listed on the U.S. National Register of Historic Places.It is a U-shaped, two-story concrete structure with Classical Revival elements including monumental portico with triangular pediment and use of columns.It was deemed significant for NRHP registration because it was the first high school in its area, and for its architecture. Its neo-classical style reflects Americanization of public education since the 1898 transition of Puerto Rico. It was built in a program along with the Ponce High School in Ponce and the Central High School in San Juan, both also NRHP-listed.