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WZMT (93.3 FM), branded on-air as Zeta 93, is a radio station licensed to Ponce, Puerto Rico, the station serves the Puerto Rico area. The station is currently owned by Spanish Broadcasting System Holding Company, Inc.

The Ponce Health Sciences University (PHSU), formerly Ponce School of Medicine & Health Sciences, is a private, for-profit university in Ponce, Puerto Rico and St. Louis, Missouri. It awards graduate degrees in Medicine (MD), Clinical Psychology (PsyD and PhD), Biomedical Sciences (PhD), Medical Sciences (MS), and Public Health (MPH and DrPH). The university has 360 students in its medical school and, as of 11 February 2019, was authorized to increase the student body at the medical school to 600 which, when fully in place, will make it the largest private medical school in Puerto Rico and one of the largest under the American flag.

Villa Pesquera is a sea-front fishing village in barrio Playa, in the municipality of Ponce, Puerto Rico. The site is one of the tourist attractions in the municipality of Ponce.

The Auditorio Juan Pachín Vicéns (English: Juan Pachín Vicens Auditorium), formerly, Coliseo Juan Pachín Vicéns (English: Juan Pachin Vicens Coliseum), a.k.a., Coliseo de Ponce, is a sports venue in the city of Ponce, Puerto Rico. The auditorium opened on 12 May 1972, under the mayoral administration of Juan H. Cintrón García and is named after basketball player Juan "Pachín" Vicéns (1934–2007). Initially known as "Coliseo de Ponce" from its inauguration in 1972 until the 1990s, it was baptized under the name Auditorio Juan Pachín Vicéns, to honor the MVP basketball player.

The Estadio Francisco ("Paquito") Montaner (English: Francisco ("Paquito") Montaner Stadium) is a multi-use stadium in Ponce, Puerto Rico. It is home to the Leones de Ponce team of the Puerto Rico Baseball League (LBPPR) and FC Leones of the Puerto Rico Soccer League (PRSL). The stadium has a capacity of 16,000 seats. Construction of the stadium began in 1947 and it opened on 15 October 1949. Montaner has the distinction of being the first stadium in Puerto Rico that installed an artificial surface field. The stadium lies next to the Juan Pachín Vicéns Auditorium, where the Ponce Lions (basketball) hold their games. The Stadium was named to honor Francisco "Paquito" Montaner, one of the greatest Puerto Rican pitchers of all times.

The Ponce Grand Prix de Atletismo is a track and field competition held yearly in Ponce, Puerto Rico at the Francisco Montaner Stadium. The event started in 2007, after the successful hosting of the 2006 Ibero-American Championships. It was considered among the most important athletic events in the Caribbean based on the competitive and organizational quality of the event. Starting with the 2012 season, the Ponce Grand Prix joined the IAAF World Challenge competitions until 2015 and represented the only other city in the Americas, outside Kingston, Jamaica, and Rio de Janeiro, Brazil in the circuit. The event was relaunched in 2022 named Puerto Rico International Athletics Classic as part of the silver level scheduled World Athletics Continental Tour.

The Municipal Building of Ponce Playa (Spanish: Edificio Municipal de la Playa de Ponce or Ponce Playa) is a historic building and former civic center and municipal offices of the Playa barrio (Ponce Playa) of the city of Ponce, Puerto Rico. The municipal building was intended to serve the Ponce Playa settlement which had significantly grown thanks to the economic and industrial activities of the Port of Ponce. It was designed by engineer Manuel V. Domenech and municipal chief engineer Victor A. Auffant in a Renaissance-inspired Spanish Revival style and built in 1904. It hosted municipal offices in addition to a police station, jailhouse and fire station. It also provided social services to the local community such as first aid and civic offices. Although the building is no longer in official municipal use it was added to the National Register of Historic Places in 2013 due to its architectural and local historic significance.

McCabe Memorial Church, also known as Iglesia Metodista Unida de la Playa de Ponce, is a historic church building in Barrio Playa in Ponce, Puerto Rico. It dates from 1908, and was designed by Antonin Nechodoma. It was listed on the U.S. National Register of Historic Places in 2008. It is one of four places such listed in Barrio Playa, the others being the U.S. Customs House, the Caja de Muertos Light, and the Cardona Island Light.

Puerto Rico Iron Works (founded as Porto Rico Iron Works) was a heavy industry iron foundry located in barrio La Playa in Ponce, Puerto Rico. The company was founded in 1918. The foundry "was Puerto Rico's most prolific steel bridge fabricator in the 20th Century" and the largest iron foundry in the Antilles. At its peak, it employed over 700 people. It closed in 1973.

Fuerte de San José, also known as Fuerte de la Playa de Ponce, was an 18th-19th-century Spanish fortress located in Barrio Playa in the municipality of Ponce, Puerto Rico. It was part of a three-fort system design to defend the Port of Ponce, the Barrio Playa seaport village and the City of Ponce from seaborne attacks. However, only two of the three fortifications materialized, with Fuerte San José being the largest and most complete. The fort was in operation 125 years, from 1760 to 20 March 1885, and was demolished in 1907 by order of the Puerto Rico Legislature to make room for the growing civilian population of Barrio Playa. Fuerte de San José has been compared to Fortín de San Gerónimo in San Juan, in terms of design, purpose and size.

Edificio Empresas Ferré (Spanish for 'Ferré Enterprises building'), today known as the Centros Sor Isolina Ferré Building, is a historic mid 20th-century International-style building located in the Ponce Playa area in the city of Ponce, Puerto Rico. It was designed by architect Robert M. Little as both workshop facilities and the administrative offices of Ferré Enterprises (Empresas Ferré), founded by Luis A. Ferré and the parent company of enterprises such as Ponce Cement and Puerto Rico Iron Works that boomed during the rapid industrialization period of Operation Bootstrap (Operación Manos a la Obra) in the aftermath of World War II.The building also hosts La Fundición, a mural painted by famed muralist Rafael Ríos Rey in 1953. Both the building and the mural were listed in the National Register of Historic Places in 2013 due to their architectural, artistic and historic significance. Edificio Empresas Ferré today hosts the Trinity College of Puerto Rico.

Hospital Damas, formerly called Santo Asilo de Damas, is a 331-bed teaching hospital in Ponce, Puerto Rico.