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Día Mundial de Ponce (Ponce World Day) is a cultural celebration held in Ponce, Puerto Rico, every year during the month of September. The celebration actually starts the Monday before Labor Day with various evening-time cultural festivities. It then culminates with the grand parade that takes place on the Sunday before Labor Day. The celebration started in 2012 and has an estimated attendance of 4,000 people. The week-long event aims to celebrate the cultural heritage of the city by giving tribute to the organizations, the people and "the great sons and daughters of the city of Ponce." The first year of this celebration, the Grand Parade took place on the last Sunday of the celebration, but starting in 2013, the week-long events ended on a Saturday and the Grand Parade was changed to take place the last Saturday. That year the celebration was also changed to occur the last weekend of September, rather than the weekend before Labor Day.

The Ponce Jazz Festival is a musical celebration that takes place every year in Ponce, Puerto Rico.

Fiestas patronales de Ponce is an annual cultural celebration held at Plaza Las Delicias in Ponce, Puerto Rico. The celebration, which commonly lasts three days, takes place in late December. Ponce's Fiestas patronales are heavily influenced by Spanish culture and religion, and are a tradition held in honor of the city's patron saint, the Virgen of Guadalupe. As such the celebration may be as old as the town itself (1692). The festivities usually include religious processions honoring its Catholic heritage. However, elements of African and local culture have been incorporated as well. They also feature parades, games, artisans, amusement rides, regional food, and live entertainment. It is attended mostly by people from the city of Ponce and its 18 surrounding barrios, but also people from all over Puerto Rico. The free event's attendance is estimated in the hundreds every day.

The Carnaval de Vejigantes, officially Carnaval de Vejigantes de La Playa de Ponce, is an annual celebration held at Barrio Playa in Ponce, Puerto Rico. The celebration, which commonly lasts three to five days, generally takes place in late January or early February. It started in 1991. It takes place at Parque Lucy Grillasca on PR-585 in Barrio Playa. The parade, one of the highlights of the carnival, usually takes off from Cancha Salvador Dijols on Avenida Hostos (PR-123) and ends at Parque Lucy Grillasca (PR-585). Attendance is estimated at over 15,000 people. It is attended by people from all over Puerto Rico, and some attendees are from as far as the United States. It is organized and operated by a community, civic, NGO group, not by any government or government agency.This carnival is different from many other carnivals in that attendees are not mere spectators, but people who are encouraged to take part in the carnival. The public is actually encouraged to come with their panderos, vejigante masks, güiros and maracas and participate ad hoc. The carnival has been called the "antesala" (gateway) to lent and to the Ponce Carnival: "This carnaval is not a fiesta patronal nor a festival. It's a town party and its essence lies in a public that participates." It aims to strengthen family bonds, create long-lasting memories, share together as a community, and keep local traditions alive.The Carnival brings together some 1,200 artists, including some 10 music bands, groups of vejigantes with over 40 people each, over 100 masked vejigantes, choreographed dancers, plus the thousands of locals who join in. This carnival has been described as a "townspeople feast of controlled chaos." Besides music, dance and food, the carnivals also features amusement rides, artisans, cheerleaders, jugglers, and arts and crafts, among other attractions. There are also workshops for children on how to make vejigante masks.

The Feria de Artesanías de Ponce (English: Ponce Crafts Fair), formally, Feria de Artesanías y Muestra de Arte de Ponce (Ponce Crafts Fair and Arts Expo), is an event that takes place every year in Ponce, Puerto Rico, where artists, craftspeople and artisans showcase their products. The products showcased are traditionally hand-made and in small quantities. The fair centers around crafts that highlight the traditional cultural background of Puerto Rico, including Taino, African, and Spanish traditions. The event started in 1974 and is reported to draw "thousands of visitors". It lasts three days and is held over a weekend during the month of April.

The Festival de Bomba y Plena de San Antón (English: San Anton’s Bomba and Plena Festival), is an annual celebration held in Ponce, Puerto Rico, as an extravaganza celebration of Bomba and Plena music genres and the traditions of Ponce's barrio San Antón. The celebration lasts 10 days and it ends on a Sunday. It is generally held in July but sometimes in November.

The Festival Nacional de la Quenepa (English: National Genip Fruit Festival) is a cultural celebration that takes place every year in Ponce, Puerto Rico. The festival centers around the genip fruit, the city's official fruit. The celebration lasts three days and takes place over a weekend (Friday through Sunday). It is generally held on the second weekend of August, but occasionally during a weekend in September. It is sponsored by the Oficina de Desarrollo Cultural (Office of Cultural Development) of the Ponce Municipal Government.

The Fiesta Nacional de la Danza (English: National Danza Festival), also known as Semana de la Danza Puertorriqueña (English: Puerto Rican Danza Week), is a cultural celebration that takes place every year in Ponce, Puerto Rico. The festival centers on the danza, a musical genre native from the city of Ponce and oftentimes called "Puerto Rico's classical music" with rhythm, tune, and cadence that are similar to the waltz. The celebration lasts a week and takes place in mid-May. It is sponsored by the Ponce Municipal Government and the Institute of Puerto Rican Culture.

The Carnaval de Ponce (English: Ponce Carnival), officially Carnaval Ponceño, is an annual celebration held in Ponce, Puerto Rico. The celebration lasts one week and it ends on the day before Ash Wednesday. Thus, it is generally held in February and sometimes in March. It is one of the oldest carnivals of the Western Hemisphere, dating back to 1858. Some authorities, such as the Smithsonian Institution, believe the Ponce Carnaval can be traced to as far back as 250 years ago. The Carnaval coincides with the Mardi Gras of New Orleans, the Carnival of Venice, and Rio de Janeiro's Carnival. The estimated attendance is 100,000. Scenes of the 2011 Carnaval Ponceño were featured in the Travel Channel on 7 August 2011.

Agüeybaná El Bravo is a stone statue to the memory of Agüeybaná II, is 1 Taíno cacique in Puerto Rico, for his bravery in fighting the Spanish invaders during the sixteenth century. It is located at Plaza Agüeybaná El Bravo in Barrio Playa, at the southeast corner of the intersection of PR-2/Ponce Bypass and Avenida Hostos, just south of sector Caracoles in Ponce, Puerto Rico.

The Ponce Health Sciences University (PHSU), formerly Ponce School of Medicine & Health Sciences, is a private, for-profit university in Ponce, Puerto Rico and St. Louis, Missouri. It awards graduate degrees in Medicine (MD), Clinical Psychology (PsyD and PhD), Biomedical Sciences (PhD), Medical Sciences (MS), and Public Health (MPH and DrPH). The university has 360 students in its medical school and, as of 11 February 2019, was authorized to increase the student body at the medical school to 600 which, when fully in place, will make it the largest private medical school in Puerto Rico and one of the largest under the American flag.

The Puente Río Portugués is a historic bridge over the former course of the Río Portugués in barrio Playa in the municipality of Ponce, Puerto Rico. The bridge was added to the U.S. National Register of Historic Places in 2015. The bridge is prominent as "the oldest longitudinal steel beams / reinforced concrete bridge built within the historic Carretera Central". It is located on Avenida Hostos, just south of its intersection with Ponce By Pass.