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Spencer Street is a major street and thoroughfare in the central business district of Melbourne, Victoria. The street was gazetted in 1837 as the westernmost boundary of the Hoddle Grid. Spencer Street is named for John Spencer, 3rd Earl Spencer, former Chancellor of the Exchequer under Lord Melbourne, Prime Minister of the United Kingdom.

West Side Place is an approved A$1 billion complex of four buildings, when built, will become some of the tallest buildings in Melbourne. The project is located on 250 Spencer Street, Melbourne.

The Melbourne Assessment Prison (MAP) is an Australian remand and reception prison located in Spencer Street, West Melbourne, Victoria. The facility is operated by the Department of Justice, part of the Victorian Government.

Spencer Street Power Station was a Victorian era coal and (later) oil-fired power station which operated on Spencer Street in central Melbourne, Victoria, Australia. The station was opened in 1894, and supplied power to the city's residents, as well as being a wholesale supplier to other municipal distributors. It came under the management of the State Electricity Commission of Victoria in 1941. By the 1960s the capacity of the station reached 109 MW, but was used only for peak load. The station was closed in 1982 after becoming redundant. Eventually deemed an eyesore, demolition commenced in 2006 and was completed in 2008.

William Angliss Institute of TAFE is a TAFE institute located in the Melbourne CBD, Victoria, Australia providing training and vocational education in Hospitality, Tourism and Culinary Arts. It is the oldest and largest provider of hospitality training in Victoria, with the capacity to train up to 1400 chefs and patissiers a year.The Institute has participated in projects in China, Vietnam, Malaysia, Cambodia, Laos, Thailand, Singapore, Tonga and Samoa. International joint venture campuses are located in China at Shanghai University, Shanghai, Nanjing Institute of Tourism and Hospitality, Nanjing, Zhejiang Tourism College, Hangzhou, China Tourism Management Institute, Tianjin.The Institute offers accredited traineeships and apprenticeships, certificates, diplomas and advanced diplomas, short courses, graduate certificates, bachelors and master degrees.

King Street is a main road in the central business district of Melbourne, Australia. It is considered a key hub of Melbourne's nightlife and is home to many pubs, nightclubs, restaurants, and adult entertainment venues.Part of the original Hoddle Grid laid out in 1837, the road has become a main traffic thoroughfare connecting Southbank and North Melbourne through the city centre. King street is named for Captain Philip Gidley King, the third Governor of New South Wales.

Wurundjeri Way is a 1.9-kilometre (1.2 mi) road running through the Docklands Development west of the Melbourne central business district. It was constructed in 1999 as part of replanning and development of the former Melbourne rail yards and docks. Wurundjeri Way runs from Montague Street, South Melbourne to Dudley Street, West Melbourne via the Charles Grimes Bridge. When the Melbourne Docklands were redeveloped in the 1990s, Footscray Road was closed as a through route and rebuilt as Harbour Esplanade. To replace the through route, Wurundjeri Way was constructed to the east. To connect to this new road Flinders Street was upgraded, and the north end of the Charles Grimes Bridge was rebuilt on a curve to connect to it. Reconstruction started in June 1999, and was completed by 2001. A feature of the road, and integral to its design and naming, is the gigantic statue of Bunjil the eagle, by Melbourne sculptor Bruce Armstrong which was constructed in the median at the south end of the road. Proposals to develop this area for new buildings including the air rights over Wurundjeri Way, may require the statue to be moved.

St James Old Cathedral, an Anglican church, is the oldest church in Melbourne, Australia, albeit not on its original site. It is one of the relatively few buildings in the central city which predate the Victorian gold rush of 1851. The building was demolished and relocated in 1914 to a corner site of King Street and Batman Street. The parish is led by the Reverend Canon Matthew Williams. The Senior Associate Minister is the Reverend Mike Raiter, who is also director of the Centre for Biblical Preaching. The Assistant Curate is The Reverend Jessica Naylor-Tatterson. The parish is served each Sunday by The Old Cathedral Voices, a semi-professional all-scholar consort choir which sings music from the Renaissance era to contemporary anthems, including regular new commissions and premieres. The organist is David Brown. More recently, the church has begun serving as the chapel for Haileybury College's City Campus. The building is listed on the Victorian Heritage Register.

Healeys Lane is a cobblestone laneway in the central business district (CBD) of Melbourne, Victoria, Australia. Located on the CBD's northern edge between King Street and William Street, Healeys Lane runs north–south between Little Lonsdale Street and Lonsdale Street, close to Melbourne's legal precinct. Previously known as Healeys Alley prior to 1915, the lane was named in the 1860s after Martin Healey. With at least 25 Korean businesses situated in the laneway or in its vicinity, Healeys Lane is known as the Koreatown of Melbourne, and is also informally referred to as "Kimchi Lane" and "Kimchi Street", with the lane attracting approximately 5000 patrons a day. Healeys Lane's designation as Melbourne's Koreatown was formalised in September 2024, with Future Melbourne Committee passing a unanimous vote in 3 September 2024 to ratify the Koreatown precinct and to approve the installation of four 3-metre tall jangseung (traditional Korean totem poles) at the entrances of the lane. The Consulate-General of the Republic of Korea in Melbourne will fund the production and installation of the jangseung, while the Melbourne City Council will cover the costs of project management and relevant approvals. In collaboration with the Melbourne Korean Business Association (MKBA), the consulate-general is aiming for an official opening ceremony for the precinct in the first half of 2025. Healeys Lane's designation as Melbourne's Koreatown sees it join Chinatown and the Greek Precinct as one of Melbourne's designated cultural precincts.

The William Booth Memorial Home fire occurred on 13 August 1966 at the William Booth Memorial Home for destitute and alcoholic men in Melbourne, Australia. With 30 dead, it remains the nation's deadliest building fire.

On 3 February 2003, a Comeng electric multiple unit train rolled away from Broadmeadows station in Melbourne, Australia, before it ran for nearly 17 kilometres (11 mi) out of control without a driver and eventually crashed into another train about to depart Spencer Street station. Train controllers attempted several times to stop or redirect the train, but were limited in their ability to intervene, instead being forced to alter the route of other trains to avert a more serious collision. Eleven people on board the stationary train were injured; authorities did not know until after the crash if any passengers were on board the runaway. An investigation identified driver error as the cause of the accident, but the runaway event prompted significant debate about the role of government authorities and private operators in ensuring safety and reliability on the Melbourne rail network.

Southern Cross railway station (until 2005 known as Spencer Street station) is a major railway station in Docklands, Melbourne. It is on Spencer Street, between Collins and La Trobe Streets, at the western edge of the Melbourne central business district. The Docklands Stadium sports arena is 500 metres north-west of the station. The station is owned, operated and maintained by Civic Nexus, a subsidiary of IFM Investors and operating as Southern Cross Station Pty Ltd, under a 30-year lease to 2036 from the Victorian State Government, as part of a public-private partnership. Southern Cross Station Pty Ltd contracts Infranexus Management Pty Ltd (Infranexus) for management services. Infranexus is also wholly owned by IFM.The station is the terminus of the state's regional railway network operated by V/Line, The Overland rail service to Adelaide, and NSW TrainLink XPT services to Sydney. It is also served by suburban rail services operated by Metro Trains, being one of five stations on the City Loop, a mostly underground railway that encircles the Central Business District. It is the second busiest railway station in Melbourne's metropolitan network, with 18.614 million passenger movements recorded in 2017/18. This figure excludes V/Line passengers who use the station. Southern Cross also has a coach terminal underneath the Spencer Outlet shopping complex. Skybus Super Shuttle services to Melbourne Airport and since 2017 to Avalon Airport operate from there, as well as Firefly Express and Greyhound Australia interstate coach services, a coach ran public bus (684) and V/Line coach services to Mildura, Yarram, Mansfield, and other parts of Victoria not served by rail.