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The Charleston Arsenal was a United States Army arsenal facility in Charleston, South Carolina, seized by state militia at the outbreak of the American Civil War.The arsenal was constructed between 1825 and 1832 by the United States government near the intersection of Ashley Avenue and Mill Street in Charleston. It served as a storage place for weapons, ordnance, and ammunition for the U.S. Army in antebellum days. (An earlier Federal arsenal, the Old Citadel, was taken out of service and after became a part of The Citadel.) The Charleston arsenal produced a considerable amount of artillery and small arms ammunition during the Mexican–American War and up to the Civil War. With the secession of South Carolina in December 1860, the Arsenal became a target for Charleston militia. South Carolina troops seized the arsenal in late December, and the Confederates held it for much of the war. Josiah Gorgas had the arsenal enlarged and modernized with the installation of steam power. For a time, it was used a barracks to house Confederate troops, including the 26th South Carolina. The arsenal was retaken by Union troops in 1865 when Charleston finally fell. On July 16, 1866, the U.S. government designated the 11.26-acre (4.56 ha) site as a Federal Military Reservation, but in 1879 the Army closed the arsenal. The building and land were sold in 1888, to the Porter Military Academy which occupied the site until it built a new campus west of the Ashley River, and in 1963 the site became part of the Medical University of South Carolina.

The College of Dental Medicine is the dental school of the Medical University of South Carolina. It is located in the city of Charleston, South Carolina, United States. It is the only dental school in South Carolina.

The William Robb House is a mid 19th-century house in Charleston, South Carolina situated at No.12 (formerly No.4) Bee Street.

The James Nicholson House is a notable early 19th-century residence in Charleston, South Carolina which has housed the Ashley Hall school since 1909. The house was built ca. 1816 for Patrick Duncan. The architect for the house is not known, but authorities cite William Jay as its possible designer; he worked in Charleston and Savannah between 1817 and 1822. James Nicholson owned the property from 1829 to 1838 when James R. Pringle bought it; after Pringle's death, his family sold it in 1845 to Secretary of the Confederate Treasury General George Trenholm. From 1877 to 1909, it was the home of Charles Otto Witte's family, the foremost banker in South Carolina. Many characters in Margaret Mitchell's Gone with the Wind novel, including Rhett Butler, were based upon residents of this historic homestead, and the O'Hara plantation itself was modeled on its grounds. The Classical Revival building is stuccoed brick. The main two floors are above a high, rusticated basement. The portico is supported by four giant-order Ionic columns with Renaissance capitals. The pediment has a three-part Gothic window. Originally open (as seen in the 1876 photograph to the left), the arches of the basement have been enclosed with windows. The house was listed in the National Register August 30, 1974.

Hominy Grill was a restaurant in Charleston, South Carolina. It was located at 207 Rutledge Avenue, in the heart of historic downtown Charleston. Just a few blocks away from the iconic Rainbow Row, the restaurant has been delighting tourists and locals alike for almost 24 years. Chef Robert Stehling has been honored by the James Beard Foundation Award as the best chef in the Southeastern United States in 2008 and the restaurant has been featured on The Best Thing I Ever Ate (Chocolate Souffle), No Reservations with Anthony Bourdain, Amazing Eats (shrimp & grits and the "Big Nasty" (a fried chicken breast between two buttery biscuits smothered in sausage gravy) and Man v. Food (season 2) (shrimp & grits and the "Big Nasty"). The restaurant features amped-up Southern classics and Lowcountry cuisine with an elevated twist.

Ashley Hall is a private school for girls located in downtown Charleston, South Carolina, United States for students in pre-kindergarten-grade 12. It was founded in 1909 by Mary Vardrine McBee, who headed the institution for many years. It is the only all-girls' independent private school in South Carolina. Ashley Hall enrolls girls 2 years to grade 12 with a coeducational preschool. For the 2019-2020 school year, Ashley Hall enrolled 640 students. The school motto is Possunt Quae Volunt, or "Girls who have the will have the ability." Ashley Hall's campus features three historic properties: James Nicholson House (McBee House), 172 Rutledge Avenue (c.1816-1820), Warren Street House, 89 Warren Street (c.1823), The Elizabeth Rivers Lewine ’54 House for Global Studies, 79 Rutledge Avenue (c.1876)

The Medical University of South Carolina (MUSC) is a public medical school in Charleston, South Carolina. It opened in 1824 as a small private college aimed at training physicians and has since established hospitals and medical facilities across the state. It is one of the oldest continually operating schools of medicine in the United States and the oldest in the Deep South. The school has expanded into a state university with a medical center and six colleges for the education of health professionals, biomedical scientists, and other health care personnel. It also operates as a center for research and has a public hospital.

The Jonathan Lucas House is a historic house in Charleston, South Carolina. Jonathan Lucas, Jr., the builder of the house, was born in England and developed milling machines for rice, which led to a boom in rice planting in South Carolina.In 1893, the home began operating as medical facility called Riverside Infirmary, part of Memorial Hospital. It was also, for time, referred to as the Old Jennings House. The National Historic Landmark house Hopsewee on the Santee River was also owned by family members, being purchased by John Hume Lucas in 1844.

Cannon Park is a 2.7 acre public park located in peninsular Charleston, South Carolina. It is bound to the north by Calhoun St. and to the south by Bennett St. To the east and west are Rutledge Ave. and Ashley Ave. respectively.

The Gov. Thomas Bennett House is a National Register property located at 69 Barre St. in Charleston, South Carolina. It was built in approximately 1825 on land which had once belonged to architect and builder Thomas Bennett, Sr. (1754-1814). It was named to the National Register of Historic Places in 1978.

The James Sparrow House is an excellent example of a Charleston single house in the late Federal style. It is named for a Charleston butcher who acquired the property at 65 Cannon St. in 1797. Several other butchers owned and lived in the house by 1825 when Christian David Happoldt bought the house. (Charleston County deed book O9, page 366) It remained in his family until 1907. (Charleston County deed book U24, page 538) It is a two and one-half story stuccoed brick house, raised on a basement of the same material. The masonry has an embellished by a dog-tooth cornice, with full return, repeated in the rake of the gable end. Quoins of stuccoed brick articulate the corners and a stringcourse of the same material delineates the floor levels. Two interior chimneys, with Gothic arched hoods, on the east side of the house were reconstructed after the earthquake of 1886. The house was listed in the National Register January 30, 1998.By 1995, the house was in terrible condition. Many of its interior details had been lost, and the exterior had suffered the loss of its piazzas. Robert and Nancy Mikell purchased the house and undertook a restoration. An addition to the rear was designed by Charleston architect Randolph Martz.

MUSC Shawn Jenkins Children's Hospital is a nationally ranked, freestanding acute care women's and children's hospital in Charleston, South Carolina. It is affiliated with the Medical University of South Carolina. The hospital features all private rooms that consist of 250 pediatric beds and 29 beds for women. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout the Carolinas. The hospital also sometimes treats adults that require pediatric care. The hospital has a rooftop helipad and is an ACS verified level I pediatric trauma center, the only one in South Carolina. The hospital features a regional pediatric intensive-care unit and an American Academy of Pediatrics verified level IV neonatal intensive care unit.Along with the main hospital in Charleston, MUSC Children's operates the ambulatory R. Keith Summey Medical Pavilion with 4 operating rooms and 2 procedure rooms.