Sanseer Mill

The Russell Company Upper Mill is an historic structure in Middletown, Connecticut, at the junction of Russell Street and East Main Street in South Farms, at the end of East Main Street's commercial and industrial development areas. Built in 1836, it is listed on the National Register of Historic Places. There is a small pond to the south. Small businesses border the street to the north, followed by the buildings of Russell Manufacturing Company, the area's most dominant feature. Russell Street crosses Sumner Brook nearby and ascends to a large residential district to the west. The mill is currently a condo-apartment complex.

Middlesex Hospital is a non-profit, acute care community hospital in Middletown, Connecticut. Its service area includes Middlesex County, Connecticut, and the lower Connecticut River Valley region. In 2015 Middlesex became the first hospital in Connecticut to join the Mayo Clinic Care Network.

Pameacha Creek is a stream in Middletown, Connecticut.

Mansfield Club Grounds, also known as Mansfield Park and Fort Hill Grounds, was a baseball ballpark located in Middletown, Connecticut. The ballpark was home to the Middletown Mansfields baseball club during the 1872 season, from May 2nd until July 4th. Like the team, it was named after Civil War General Joseph K. Mansfield. The land for the ballpark, which overlooked Middletown, the Connecticut River, and the Valley Railroad, was donated in 1871 by Dewitt Clinton Sage who owned a nearby brick factory. The former site is now a residential development.

The Wilcox, Crittenden Mill, also known as Wilcox, Crittenden Mill Historic District, is a 17-acre (6.9 ha) property in Middletown, Connecticut that was listed on the National Register of Historic Places in 1986. It was the location of the Wilcox, Crittenden company, a marine hardware firm. The historic district listing included four contributing buildings and three other contributing sites.

St. Mary of Czestochowa Parish (Polish: Parafia św. Marii Częstochowskiej w Middletown) is a Catholic church parish in Middletown, Connecticut that was founded for Polish immigrants. The St. Mary of Czestochowa Church is a church building at 79 South Main Street in Middletown. The parish was founded in 1903. It is one of the Polish-American Roman Catholic parishes in New England in the Roman Catholic Diocese of Norwich.

The Metro South Historic District encompasses a portion of the downtown area of Middletown, Connecticut. Extending south from Main and College Streets for two blocks, this area was developed in the 19th century, and contains a diversity of well-preserved architecture from that period, some with association to locally important individuals. It was listed on the National Register of Historic Places in 1980.

Located in Middletown, Connecticut, the Middletown South Green Historic District was created to preserved the historic character of the city's South Green and the historic buildings that surround it. It is a 90-acre (36 ha) historic district that includes a concentration of predominantly residential high-quality architecture from the late 19th century. It was listed on the National Register of Historic Places in 1975.

The Middletown, Connecticut Christopher Columbus statue was a memorial to Columbus that was installed in the city's Harbor Park. The sculpture was donated to the city in 1996 by the Italian American Civic Order, the Italian Society of Middletown and local Italian-American families.The statue has been repeatedly vandalized. In 2016 the test on its plinth, reading "discoverer of America" was changed to "looter of America". It was damaged in 2017 when vandals chipped away the sculpture's nose. Also in 2017, vandals painted the statue's hands in red, and left the spray-painted text "kill the colonizer" on the statue's base. In 2019 it was vandalized again with red spray-paint.The statue was removed in June 2020.

The Middletown Alms House is a historic building at 53 Warwick Street in Middletown, Connecticut, constructed in 1813–1814. It was originally used as a poorhouse and is the oldest surviving building built for housing the poor in Connecticut, as well as one of the oldest such in the United States.: 6  One of the largest structures of the Federal period in Middletown, it was listed on the National Register of Historic Places in 1982.

The Middletown Woodrow Wilson High School is a former high school, now used as residential apartments, located at 339 Hunting Hill Avenue, Middletown, Connecticut. Built in 1931, it was the city's first unified high school, a role it served until 1958. It then served as a junior high school before being adapted to its present residential use. The building was listed on the National Register of Historic Places in 1986.

Connecticut Valley Hospital in Middletown, Connecticut, is a public hospital operated by the state of Connecticut to treat people with mental illness. It was historically known as Connecticut General Hospital for the Insane. It is a 100-acre (40 ha) historic district that was listed on the National Register of Historic Places in 1985.The historic district includes late 19th and 20th century revival and late Victorian architecture. When listed on the National Register, the district included 27 contributing buildings. Also included were 25 non-contributing buildings.