Spring Street station (IRT Lexington Avenue Line)

Lieutenant Joseph Petrosino Square is small triangular park in lower Manhattan in New York City, bounded by Cleveland Place and Lafayette and Kenmare Streets, two blocks north of the old police headquarters at 240 Centre Street, at the juncture of the Little Italy, Nolita, and SoHo neighborhoods. Formerly Kenmare Square, it changed its name in 1987 in honor of Lieutenant Joseph Petrosino, an early 20th century NYPD official dedicated to investigating and combating, among other adversaries, the Black Hand, an early version of the Mafia in America. The park underwent a $2 million renovation in 2008–2011, and is the site of a controversial CitiBike docking station.

Storefront for Art and Architecture is an independent, non-profit art and architecture organization located in SoHo, Manhattan in New York City. The organization is committed to the advancement of innovative positions in architecture, art and design.

Balthazar is a French brasserie restaurant located at 80 Spring Street (between Broadway and Crosby Street) in SoHo in Manhattan, in New York City. It opened on April 21, 1997, and is owned by restaurateur Keith McNally.: 182 McNally also owns Pastis, Cafe Luxembourg, Lucky Strike, the Russian-themed bar and restaurant Pravda, Odeon in Tribeca, and Schiller's Liquor Bar on the Lower East Side. Balthazar Bakery was later opened, at 80 Spring Street.McNally opened Balthazar in the theater district in Covent Garden in London, in February 2013. Balthazar London will reside within a building known as The Flower Cellars, sharing the space with The London Film Museum. The general manager will be Byron Lang.

Taïm is an Israeli restaurant located at 45 Spring Street (on the corner of Mulberry Street), in NoLita in Manhattan, New York City. "Taïm" means "tasty" in Hebrew.The Spring Street location opened in October 2012. Another location is at 222 Waverly Place (near Perry Street), in the West Village since 2005. There are now 7 other restaurant locations, including 2 restaurants in the Washington, DC area as well as a newly opened location in the Park Slope neighborhood of Brooklyn.

DeSalvio Playground is a neighborhood park located on the corner of Spring Street and Mulberry Street in NoLita, in Manhattan, New York City.The playground has modular play equipment that is red, white, and green (in honor of the Italian flag), built-in stone chess tables, a basketball half-court, and benches.

The Ravenite Social Club was an Italian American heritage club at 247 Mulberry Street, in Little Italy, New York City. It was used as a mob hangout and the storefront later became a shoe store, and as of 2022 is a men's clothing store.

Soho Synagogue was a "hipster" synagogue located in the SoHo neighborhood of Manhattan, New York. On September 15, 2009, The SoHo Synagogue signed a 7-year lease for the ground floor of 43 Crosby Street, located between Spring and Broome Streets. Designer Dror Benshetrit designed the synagogue space.The SoHo Synagogue was founded in 2005 by Chabad-Lubavitch Rabbi Dovi Scheiner and his wife Esty.

Judson Health Center, founded in 1921, was an early New York City Community Health Center inspired by the Rev. Alonzo Ray Petty of the Baptist Judson Memorial Church located at 55 Washington Square South. Petty appealed to fellow Baptist and physician Eleanor A. Campbell to start the health and dental clinic, initially located in the church's basement, in order to provide care to the many Italian immigrants living on the west side of lower Manhattan. Many of these 45,000 residents suffered from poor nutrition; rickets was prevalent among many of the area's children. The health center quickly outgrew its space and in 1922 moved to Judson House at 237 Thompson Street. In 1924 the clinic provided healthcare to 22,000 visitors and also conducted 14,000 field visits, making the center the largest of its kind in the U.S. In 1950 the Center moved to 34 Spring Street and served residents living in the area bordered by Broadway, Washington Square and the Hudson River. The Center provided healthcare in over one million separate visits to residents and immigrants between 1921 and 1957, when Dr. Campbell was awarded the Star of Italian Solidarity by the Italian Government. Campbell, who refused any wages for her services throughout her lifetime, was born Eleanor Milbank Anderson, the daughter of philanthropist and public health advocate Elizabeth Milbank Anderson (1850-1921) and the artist Abraham Archibald Anderson (1846-1940). Judson Health Center continues to operate today at the Spring Street location under the auspices of the New York City Health and Hospitals Corporation.

The Church of the Divine Unity was a former Unitarian and Universalist church located on the east side of Broadway between Prince and Spring Streets, SoHo, Manhattan. It was built c.1845 and likely transferred to American Unitarian Association after c. 1854. Subsequently, it was adaptively reused as an art gallery (the Düsseldorf Gallery), then an office, and finally was demolished sometime before 1866.“On August 6, 1866, [prolific diarist George Templeton] Strong observed ‘another material change in the aspect of Broadway:’ ‘Taylor’s showy restaurant” had become the office of the American Express Company, and Capin's Universalist Church, which had been serving as an art gallery, on the east side of Broadway between Prince and Spring Streets, was demolished. Strong, neither an apologist for the past nor a dedicated futurist, took a fatalist view: ‘So things go. Let ‘em go!’

Lombardi's is a pizzeria located at 32 Spring Street on the corner of Mott Street in the Nolita neighborhood in the borough of Manhattan, New York City. Opened in 1905, it has been recognized by the Pizza Hall of Fame as the first pizzeria in the United States.

Grotta Azzura, named for the Blue Grotto on the Isle of Capri is an Italian restaurant on the corner of Mulberry Street and Broome Street in the Little Italy section of the borough of Manhattan in New York City. The dining establishment was founded in 1908 by the Davino family and reopened in October 2003 in its original space after having been shut for six years. It is noted for having been a frequent haunt of Frank Sinatra and the Rat Pack as well as Enrico Caruso. In its later incarnation, it was a hangout for Heath Ledger, the young actor who spent some of his final days living in a rented loft space at 41 Broome street just down the street from the eatery.Grotta Azzura was one of the first places to serve "Lobster Fra Diavolo" (from the devil in Italian), an Italian American dish rather than a continental Italian one. Wine expert Victor Hazan and his wife the chef Marcella Hazan once told The New York Times that they first remembered eating it there circa 1940. Marcella went on to say "You brought me to that restaurant. I remember the dish clearly because it was so heavy and typical of Italian cooking in America. We don't eat like that in Italy".In 1977, a member of the restaurant's founding family, John Davino published a book of recipes associated with the establishment called The Recipes of the Grotta Azzurra.

Staley-Wise Gallery is a fine art photography gallery located in New York City, focusing on fashion photography, as well as portraiture, landscape, still life and nudes. The gallery was founded in 1981 by Etheleen Staley and Taki Wise.