Plaza del Quinto Centenario

Galería Nacional (National Gallery) located in Old San Juan within the historic colonial section of the capital of Puerto Rico, houses the largest collection of Puerto Rican paintings from the eighteenth century to the 1960s. The museum is located in the restored Saint Aquinas monastery of the Dominican Order. The monastery along with the adjoining San José Church is one of the first significant works of architecture on the island. The museum's holdings include many important works by José Campeche, Francisco Oller, Ramón Frade, and Rafael Tufiño. The museum is administered by the Institute of Puerto Rican Culture.

The Roman Catholic Archdiocese of San Juan de Puerto Rico (Latin: Archidiœcesis Sancti Joannis Portoricensis) is an ecclesiastical territory or diocese of the Catholic Church in the United States, comprising the northeast portion of the island of Puerto Rico. Its jurisdiction includes the municipalities of Dorado, Toa Baja, Cataño, Toa Alta, Bayamón, Guaynabo, San Juan, Trujillo Alto, and Carolina.

San José Church (Spanish: Iglesia de San José), located in Old San Juan within the historic colonial zone of the capital of Puerto Rico, is one of the first significant works of architecture on the island. The church is one of the earliest surviving examples of 16th-century Spanish Gothic architecture in the Western hemisphere.In 2013 it was added to the National Trust for Historic Preservation's list of 11 Most Endangered Historic Places of 2013.

The Academia Puertorriqueña de la Lengua Española (Spanish for Puerto Rican Academy of the Spanish Language) is an association of academics and experts on the use of the Spanish language in Puerto Rico. It was founded in San Juan on January 28, 1955. It is a member of the Association of Spanish Language Academies. The association works with the Royal Spanish Academy to add new words to the Spanish lexicon. In 2017, the academy was instrumental in adding the word "reguetón" to the official Spanish dictionary.The academy put together a website with Puerto Rican vocabulary which can be searched by themes.

Museo de las Américas is a multidisciplinary museum in San Juan, Puerto Rico dedicated to the arts, folklore, architecture and broader history of the Americas. Its mission is to offer a synoptic view of the history and culture of the Americas from ancient to contemporary, emphasizing in Puerto Rico and its relationship to the continent, through exhibition programs and cultural activities. Founded in 1992 by Ricardo Enrique Alegría Gallardo, a professor at the Universidad de Puerto Rico and founder of the Institute of Puerto Rican Culture, the museum is dedicated to its role in preserving and perpetuating Puerto Rican arts and culture, both within the territory and abroad. Among its temporary exhibitions, the museum has four permanent exhibitions: The Popular Arts in the Americas, The African Heritage, The Indigenous of America and Conquest and Colonization: Birth and Evolution of the Puerto Rican Nation. Museo de Las Americas is a multidisciplinary, multicultural and multidimensional learning museum, responding to a diverse community, which allows it to consolidate itself as a cutting-edge institution in Puerto Rico. It is currently housed in the former Ballajá Barracks, built between 1854 and 1864 as one of the last major architectural projects of the Spanish colonial rule over the island before it was annexed by the United States in 1898. Initially, when Puerto Rico was annexed by the United States, the federal government paid the Catholic Church for this property, among others in the area. Ownership of the property, claimed by the Catholic Church, was not a straightforward matter and had to be resolved by the Supreme Court. The Government of Puerto Rico acquired the building in 1976 through a transfer from the Government of the United States with the commitment of restoring it and using it for cultural, educative, and touristic purposes. In 1986, a reform plan for the San Juan Historic Zone was sketched and the building was restored from 1990 to 1993.

The Center for Advanced Studies on Puerto Rico and the Caribbean (Spanish: Centro de Estudios Avanzados de Puerto Rico y El Caribe) is a private institute housed in the former San Ildefonso Conciliar Seminary in Old San Juan, San Juan, Puerto Rico that offers graduate studies in arts and philosophy. It was incorporated on February 28, 1968, by Pablo Casals, Luis Muñoz Marín, Roberto Busó Carrasquillo, and Jaime Benítez. However, it remained inactive and without organization until 1976, when Ricardo Alegría made a request before the Council on Higher Education of Puerto Rico to transform the center into an academic institution. The center is currently accredited by the Middle States Association of Colleges and Schools and it publishes La Revista del Centro de Estudios Avanzados de Puerto Rico y el Caribe.

The Institute of Puerto Rican Culture (Spanish: Instituto de Cultura Puertorriqueña), or ICP, for short, is an institution of the Government of Puerto Rico responsible for the establishment of the cultural policies required in order to study, preserve, promote, enrich, and diffuse the cultural values of Puerto Rico. Since October 1992, its headquarters have been located at the site of the old colonial Spanish Welfare House in Old San Juan. The ICP was created by order of Law Number 89, signed June 21, 1955, and it started operating in November of that year. Its first Executive Director was Dr. Ricardo Alegría.

Casa Blanca is a house museum located in Old San Juan within the historic colonial section of the capital of Puerto Rico.

The Pablo Casals Museum (Spanish: Museo Pablo Casals), located on San José Square in Old San Juan, San Juan, Puerto Rico, is a museum dedicated to the Catalan Puerto Rican cellist, composer and conductor Pablo Casals, who lived the last 17 years of his life in San Juan where he composed his masterpiece El Pessebre. In addition to his piano, his cello, historical photographs, some of his musical instruments and personal belongings, the museum also has a media and music library which visitors can browse.

The Ballajá Barracks (Cuartel de Ballajá in Spanish) is a historic building and former military barracks located in the Ballajá section of Old San Juan, in the city of San Juan, Puerto Rico. It is located close to El Morro and its esplanade, between the Morovis, Beneficiencia and Norzagaray streets. It was built from 1854 to 1864 to house Spanish and Puerto Rican regiments. The Ballajá Barracks were the last large-scale construction project made by the Spanish Crown in the Americas.The building has been owned by the government of Puerto Rico since 1976 and today it houses the Museum of the Americas and the Puerto Rican Academy of the Spanish Language, in addition to several businesses and institutions such as a dance school, exhibition spaces, restaurants and the State Office of Historic Conservation.

The Santa María Magdalena de Pazzis Cemetery is a colonial-era cemetery located in Old San Juan, Puerto Rico. It is the final resting place of many of Puerto Rico's most prominent natives and residents. Construction began in 1863 under the auspices of Ignacio Mascaro. The cemetery is located outside the walls of Fort San Felipe del Morro fortress, one of the island's most famous landmarks. The average height of the wall is 40 feet and the width ranges from 15 to 20 feet. It was named in honor of Saint Maria Magdalena de Pazzi. According to Rafael Rodríguez, Chaplain and director of pastoral services at the Universidad del Sagrado Corazón located in the Santurce district of the capital, the location of the cemetery is central to the Puerto Rican belief in the separation of death and life. The colonial Spanish government at the time construction of the cemetery commenced, viewed death with fear because it was a mystery. Therefore, they decided to build the cemetery to overlook the Atlantic Ocean to symbolize the spirit's journey to cross over to the afterlife.

Mercado, located within Old San Juan, is one of 7 subbarrios in San Juan Antiguo barrio in the municipality of San Juan in Puerto Rico.