Eastern Niagara Hospital

Lowertown Historic District is a national historic district located at Lockport in Niagara County, New York. The district is predominantly residential in nature, with some commercial structures and warehouses. The mose elegant homes are along Market Street, east of Chapel Street, facing the Erie Canal. Notable structures in this district include the Western Block Company Warehouse, a 2+1⁄2-story stone structure built before 1855; Lockport Bank Building built in 1829, and located at 315-319 Market Street; Washington Hunt House, built in 1831 and home to New York Governor Washington Hunt, and located at 363 Market Street; the former Christ Episcopal Church at 425 Market Street; and the Vine Street School, an Italianate style one-room school built in 1864.It was listed on the National Register of Historic Places in 1973.

The Nathan Comstock Jr. House (also known as the Odd Fellows Orphanage) is a historic house located at 299 Old Niagara Road in Lockport, Niagara County, New York.

Thomas Oliver House is a historic home located at Lockport in Niagara County, New York. It is a 2+1⁄2-story Queen Anne style brick dwelling built in 1891.It was listed on the National Register of Historic Places in 1998. It is located in the High and Locust Streets Historic District.

Union Station is a historic train station located at Lockport in Niagara County, New York. It was constructed in 1889, for the New York Central Railroad in the Romanesque style. It was deactivated as a station in the 1940s and lay unused until 1967. It was renovated and reopened as a restaurant in 1971. The restaurant was gutted by fire in December 1974, rebuilt and again destroyed by fire in 1978.It was listed on the National Register of Historic Places in 1977.The current owner of the building and property is Mark Davidson. He has plans for a full restoration pending state grants.

Conkey House is a historic home situated Lockport in Niagara County, New York. It is a stone structure built in 1842 in the Federal style by James Conkey, an early settler of Lockport. It was owned by his descendants until the 1960s. It is one of approximately 75 stone residences remaining in the city of Lockport.It was listed on the National Register of Historic Places in 2003.

Cold Springs Cemetery (also known as Cold Spring Cemetery) is a historic cemetery located at Lockport in Niagara County, New York. Among the prominent burials are Erie Canal proponent Jesse Hawley, Cuthbert W. Pound, Chief Judge of the New York Court of Appeals from 1932 to 1934, and World War II Medal of Honor recipient William F. Leonard. Incorporated in 1841, the cemetery was listed on the National Register of Historic Places in 2004.

Chase-Hubbard-Williams House is a historic home located at Lockport in Niagara County, New York. It is a stone structure built in 1870 in the Italianate style. A 1900 remodeling was in the Colonial Revival style. In 1958, the property was acquired by the Presbytery of Buffalo and Niagara and converted to a nursing home. It is one of approximately 75 stone residences remaining in the city of Lockport.It was listed on the National Register of Historic Places in 2008. It is located in the High and Locust Streets Historic District.

The Chase-Crowley-Keep House is a historic house located at 305 High Street in Lockport, Niagara County, New York.

The United States Post Office is a historic post office building located at Lockport in Niagara County, New York. It was designed and built 1902–1904, and is one of a number of post offices in New York State designed by the Office of the Supervising Architect of the Treasury Department, James Knox Taylor. It is a three-story brick and limestone structure in the Beaux-Arts style. The United States District Court for the Western District of New York met here from 1904 until 1916. It was listed on the National Register of Historic Places in 1989.

Lockport Industrial District is a national historic district located at Lockport in Niagara County, New York. The district features the two sets of Erie Canal locks constructed in 1859 and 1909–1918, respectively known as the Northern Tier and Southern Tier. Also in the district are the remains of industrial buildings built along the related hydraulic raceway along the north side of the canal.It was listed on the National Register of Historic Places in 1975.

Lockport is both a city and the town that surrounds it in Niagara County, New York, United States. The city is the Niagara county seat, with a population of 21,165 according to 2010 census figures, and an estimated population of 20,305 as of 2019.Its name derives from a set of Erie Canal locks (Lock Numbers 34 and 35) within the city that were built to allow canal barges to traverse the 60-foot natural drop (18 m) of the Niagara Escarpment. It is part of the Buffalo–Niagara Falls metropolitan area.

High and Locust Streets Historic District is a national historic district located at Lockport in Niagara County, New York. The district encompasses 120 contributing buildings in a predominantly residential section of Lockport. The district developed between about 1840 and 1936, and includes buildings in a variety of architectural styles including Greek Revival, Italianate, Queen Anne, Colonial Revival, Classical Revival, and Bungalow / American Craftsman. Located in the district are the separately listed Chase-Crowley-Keep House, Chase-Hubbard-Williams House, and Thomas Oliver House. Other notable buildings include the F.N. Nelson House (c. 1850), Calvin Haines/Alonzo J. Mansfield House (c. 1860), J. Dunville House (c. 1907), Ambrose S. Beverly House (c. 1875), Dr. Martin S. Kittinger House (c. 1870), and F. N. Nelson House/Lockport Home for the Friendless (c. 1850).It was listed on the National Register of Historic Places in 2014.