Lucy Addison High School

Harrison School is a historic public school building for African-American students located at Roanoke, Virginia. It is a rectangular, 13-bay brick building done in modified Georgian Revival architecture. The school was built in 1916 with two-story wings added in 1922. It was the first school in the city to educate black students beyond the seventh grade level, and its first principal was the noted educator Lucy Addison. After closing as a school in the 1960s, the building served as a child care center and later low-income housing as well as the home of the Harrison Museum of African American Culture. It was listed on the National Register of Historic Places in 1982.

Melrose–Rugby Historic District is a national historic district located in the Melrose–Rugby neighborhood of Roanoke, Virginia. It encompasses 111 contributing buildings and 2 contributing objects in a planned residential subdivision, with most of the dwellings being built between the late 1910s and late 1940s. It is a primarily residential district with single-family dwellings. The houses include American Craftsman-style bungalow, American Foursquare, and Cape Cod style.It was listed on the National Register of Historic Places in 2013.

The Basilica of St. Andrew, also known as St. Andrew's Catholic Church, is a historic Roman Catholic church and rectory in Roanoke, Virginia, United States. It was built in 1900-1902, and is a buff brick church on a stone foundation in the High Victorian Gothic style. It has a cruciform plan and features two tall Gothic towers which flank the main entrance and are square in plan. On each tower are two small lancet windows, two large pointed-arch stained-glass tracery windows, and sets of double pointed-arch openings at the belfry. Also on the property is a rectory built in 1887. The church replaced an earlier small brick church built in 1883.The building cost $60,000 to construct, with another $40,000 budgeted for interior appointments and trim. "The buff brick edifice with stone trimming, designed by W. P. Genter of Akron, Ohio, would become a Roanoke landmark."It was listed on the National Register of Historic Places in 1973.The church has had two major renovations since its completion. The first renovations took place after the Second Vatican Council authorized certain liturgical alterations. A freestanding altar was installed so that Mass could be celebrated versus populum, the priest facing the people. The ornate high altar was left in place and intact. Later, the original freestanding altar was replaced with a more ornate, marble one that remains in use to this day. At the same time the interior was radically modified to remove two side altars, a long altar rail, and a select portion of iconography. The lighting of the church was also renovated to allow a brighter hue. From 2010 to 2014, St. Andrew's saw its most expensive long-term renovation. The large pipe organ, being an object of much effort to maintain, was replaced with an electric organ. The pipes, however, were retained for decoration. In 2014, the steeples, originals from the construction of the church, were removed and renovated. On September 6, 2023, the Dicastery for Divine Worship and the Discipline of the Sacraments granted the title of minor basilica to the parish.

The Gainsboro Branch of the Roanoke City Public Library, also known as the Gainsboro Library, is a historic library building located in the African-American neighborhood of Gainsboro in Northwest Roanoke, Virginia. It was built in 1941–1942, and is a one-story, seven-bay, L-plan Tudor Revival style brick building. The library provided African-American residents of Roanoke's segregated Gainsboro neighborhood with a library facility where children and adults could pursue self-education with advice and assistance from competent and dedicated librarians. It replaced Roanoke's first African-American library which had been established in 1921 in a rented commercial storefront space. Land for the new building was purchased from St. Andrew's Catholic Church. "...Mrs. Lee asked Father Thomas of St. Andrew's Catholic Church about leasing church land in the Gainsboro area for a library. He didn't have the authority to do that himself, but instead helped Mrs. Virginia Dare Young Lee draft a letter to Pope Pius XII in Rome about the matter. The Pope's response was beyond all expectations. Land was granted '...for ninety-nine years for the use of the Public Library.'"The deep slate roof and large bay windows give the library building a home-like appearance, as does the high ceilings and large rooms.It was listed on the National Register of Historic Places in 1996, and is part of the Gainsboro Historic District. It underwent significant renovations in 2009 and 2020.

Gainsboro Historic District is a national historic district located of Roanoke, Virginia. It encompasses 202 contributing buildings and 1 contributing structure in the African-American neighborhood of Gainsboro in Northwest Roanoke. They include single- and multiple-family dwellings, three churches; one parish hall, the Gainsboro Library, a theater, a hotel, two medical office buildings, six commercial buildings, one industry and one bridge. The buildings were primarily built between 1890 and 1925. Located in the district are the separately listed Gainsboro Branch of the Roanoke City Public Library and Henry Street Historic District.It was listed on the National Register of Historic Places in 2005.

Gilmer is a neighborhood in central Roanoke, Virginia, USA, abutting the Norfolk Southern rail yard that initially developed in the 1920s as an early Roanoke suburb. It borders the neighborhoods of Harrison on the north, Gainsboro to the east and Loudon-Melrose to the west. Both the West End and Hurt Park are to the south and can be accessed via the 10th Street Bridge across the railroad gulch. Founded in 1980, the Northwest Neighborhood Environmental Organization is the community development corporation active within the Gilmer neighborhood.

Roanoke Catholic School is a private, Roman Catholic K-12 school in Roanoke, Virginia, United States.

Henry Street Historic District is a national historic district located at Roanoke, Virginia. It encompasses four contributing buildings constructed between 1917 and 1951. They were developed as the central business and entertainment district for the African-American neighborhood of Gainsboro in Northwest Roanoke. They are the Hotel Dumas (1917), The Strand Theatre (1923), Dr. Lylburn Downing office (c. 1945), and a commercial building (1951).It was listed on the National Register of Historic Places in 2004. The buildings are also included in the Gainsboro Historic District.

The Virginia Museum of Transportation (VMT) is a museum in Downtown Roanoke, Virginia, that is devoted to the topic of transportation.

Norfolk and Western Railway Freight Station is a historic freight depot located in the Melrose-Rugby neighborhood of Roanoke, Virginia. It encompasses 111 contributing buildings and 2 contributing objects in a planned residential subdivision, with most of the dwellings being built between the late 1910s and late 1940s. It is a primarily residential district with single-family dwellings. The houses include American Craftsman-style bungalow, American Foursquare, and Cape Cod style. The building houses the Virginia Museum of TransportationIt was listed on the National Register of Historic Places in 2013.

Norfolk and Western 1218 is a preserved four-cylinder simple articulated 2-6-6-4 steam locomotive, built in June 1943 by the Norfolk and Western's (N&W) Roanoke (East End) Shops in Roanoke, Virginia as part of the N&W's class "A" fleet of fast freight locomotives. It was retired from regular revenue service in July 1959, and was later restored by Norfolk Southern for excursion service for their steam program, pulling excursions throughout the eastern United States from 1987 to 1991. It is currently on display at the Virginia Museum of Transportation in Roanoke, Virginia.

Gainsboro is a Roanoke, Virginia neighborhood located in central Roanoke immediately north of Downtown, across the Norfolk Southern Railway right of way, between Interstate 581 and Orange Avenue. It borders the neighborhoods of Harrison and Gilmer on the west, Washington Park on the north, Williamson Road on the east and Downtown Roanoke on the south. As of the 2000 U.S. Census, Gainsboro has a population of 967 residents.