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The Franciscan Monastery is located near the Main Square in Plzeň, Czech Republic. Originally belonging to the Minorites, the later Franciscan monastery was founded at the end of the 13th century. The Church of the Assumption of the Virgin Mary, Chapterhouse and Chapel of St. Barbara also belong to the monastery complex. The Franciscan church and monastery are among the city's oldest buildings and, for all the calamities of the Hussite era and Thirty Years' War, have, in essence, preserved their original early Gothic form.

Josef Kajetán Tyl Theatre (Czech: Divadlo Josefa Kajetána Tyla) is a main theatre in Plzeň, Czech Republic. The theatre was built between 1899 and 1902 in the neo-renaissance style with some art nouveau elements to the design of Antonin Balsanek. Every year the theatre performs some 18 premieres of drama, operas, operettas, ballets or musicals. Since September 2014, actors of the theatre also perform at the New Theatre.In front of the façade stands a statue of Josef Kajetán Tyl by Alois Soper.

The siege of Pilsen lasted from 14 July 1433 to 9 May 1434 and was an important encounter of the Hussite Wars. Hussite troops led by Prokop the Great had unsuccessfully besieged the Catholic city of Pilsen for nine months and twenty three days. Failure to capture one of the last major Catholic cities in Bohemia along with the fall of New Town was a huge blow for the Hussite groups that foreshadowed their decisive defeat in the Battle of Lipany.

The Square of the Republic (in Czech Naměstí republiky) forms the historical centre of Plzeň, Czech Republic. With a size of 552 by 627 feet (168 m × 191 m) it is one of the largest medieval squares in the Czech lands. Plzeň as a town appears at the end of the 13th century, the square existing since then. Around the oblong square regular blocks of houses delimitated by a rectangular network of streets were built. Archaeologists have identified wooden pavement from the 13th century and another three layers of pavement from the 14th century. The square was cobblestoned in 1859. The stones were replaced by asphalt cover in the 20th century; this replaced again with cobblestones during 2005-2007 reconstruction. In the beginning of the 16th century the water supply became critical. A water tower with a mechanical pump was erected, the water being stored in a leaden reservoir and fed through wooden pipes to public fountains at the main square. A graveyard had existed on the square since the town was established until 1789, when Emperor Joseph II ordered to close such graveyards. The buildings in the square are of predominantly build in Gothic and Renaissance styles. In the courtyards east side remains of the medieval walls are still preserved. The best preserved part of the square is its southern part. Many buildings contain two or three levels of cellars used to preserve food, for wells or as cesspools.The most important historical landmarks are Church of St. Bartholomew (1295, since 1993 a cathedral), the city hall (the building serves as city hall since 1496) and St. Mary's plague column from 1681 by the Plzeň sculptor Kristian Widman, all in the northern part of the square.

Plzeň (Czech pronunciation: [ˈpl̩zɛɲ] (listen); German and English: Pilsen, in German pronounced [ˈpɪlzn̩] (listen)) is a city in the Czech Republic. About 90 kilometres (56 miles) west of Prague in western Bohemia, it is the fourth most populous city in the Czech Republic with about 181,000 inhabitants. The city is known worldwide for Pilsner beer, created by Bavarian brewer Josef Groll in the city in 1842.

The Cathedral of St. Bartholomew (originally the Church of St. Bartholomew) is a Gothic church located on the Main Square in Plzeň, Czech Republic. It was probably established together with the city around the year 1295. The church became a cathedral in 1993, when the Plzeň diocese was created. It was designated a national cultural monument of the Czech Republic in 1995.

The siege of Pilsen (or Plzeň) or Battle of Pilsen was a siege of the fortified city of Pilsen (Czech: Plzeň) in Bohemia carried out by the forces of the Bohemian Protestants led by Ernst von Mansfeld. It was the first major battle of the Thirty Years' War. The Protestant victory and subsequent capture of the city enlarged the Bohemian Revolt.

The Great Synagogue (Czech: Velká synagoga) in Plzeň, Czech Republic is the second largest synagogue in Europe.

Plzeň main railway station (Czech: Plzeň hlavní nádraží, abbreviated Plzeň hl.n.) is the principal railway station in Pilsen, the largest city in western Bohemia. The station is located in the Slovany district near the city center. The station was opened in 1862, together with the Czech Western Railway from Prague to Pilsen. The station has six platforms for train transport and one platform for buses. There are also tram and trolleybus stops. The station is electrified. As of 8. March 2023, the station is undergoing major reconstruction.

The New Theatre (Czech: Nové divadlo) in Plzeň is a Czech theatre. Construction of the venue cost 880 million CZK. The first performance at the New Theatre was The Bartered Bride from Bedřich Smetana.

Plzeňský Prazdroj, a. s. (pronounced [ˈpl̩zɛɲskiː ˈprazdroj a ˈɛs]), known in English as the Pilsner Urquell Brewery, is a Czech brewery opened in 1842 and headquartered in Plzeň, Czech Republic. It was the first brewery to produce pale lager, branded as Pilsner Urquell, which became so popular and was so much copied that more than two-thirds of the beer produced in the world today is pale lager, sometimes named pils, pilsner and pilsener after Pilsner Urquell. The brewery name, Pilsner Urquell, which can be roughly translated into English as "the original source at Pilsen", was adopted as a trademark in 1898. Pilsner Urquell is the largest producer and exporter of beer in the Czech Republic.The brewery was part of the SABMiller group of companies (at first South African Breweries) from 1999 to 2017. As part of the agreements made with regulators before Anheuser-Busch InBev was allowed to acquire SABMiller in October 2016, Pilsner Urquell (excluding certain geographical areas) was sold to Japan-based Asahi Breweries in March 2017.

Pilsen Plaza (Czech: Plzeň Plaza) is a 20,000-square-metre (220,000-square-foot) shopping mall and entertainment center in Plzeň, Czech Republic.