Statue of Martin Luther King Jr. (Pueblo, Colorado)

The J. L. Streit House, at 2201 Grand Ave. in Pueblo, Colorado, is a Queen Anne-style house which was built in 1888. It was listed on the National Register of Historic Places in 1984.Its front is dominated by a polygonal tower which gave rise to it being known locally as the "octagon house".It was designed by local architect Patrick P. Mills (d.1933).It was deemed significant " due to its historic role in the development of Pueblo as one of the premier model homes for the Dundee Investment Company, and for its unique octagonal frontal tower which gained, for it, local landmark status as the brainchild of pioneer architect, P. P. Mills." It has also been known as the Creel House.

Pueblo Mall is a shopping mall in Pueblo, Colorado, U.S. Opened in 1976, the mall features Dillard's and J. C. Penney as its anchor stores. Other major tenants of the mall include Jo-Ann Fabrics, Planet Fitness, and Altitude Trampoline Park. The mall is managed and owned by Centennial Real Estate.

The R.T. Frazier House is a historic Craftsman style residence built in 1915 in Pueblo, Colorado. It was listed on the National Register of Historic Places in 1985. It was deemed significant for its association with R.T. Frazier and as an architectural work.

Parkview Medical Center is a private, non-profit teaching hospital located in Pueblo, Colorado. The hospital has 370 licensed beds. In the last year with available data, the hospital had 14,617 admissions, 69,023 emergency department visits, performed 5,963 inpatient surgeries, and 6,657 outpatient surgeries. Parkview Medical Center is accredited by the Commission on Accreditation of Rehabilitation Facilities.

The Rosemount Museum, pronounced "Rosemont" is a historic house museum in Pueblo, Colorado, it is situated on a square block at the corner of one of the highest points in north Pueblo and across the street from Parkview Medical Center. It is a 24,000-square-foot, three story mansion with attic and basement and contains thirty-seven rooms. It was begun in 1891 and completed in 1893 for John A. Thatcher and his family. A 6,000-square-foot carriage house was also built on the property.

The Temple Emanuel in Pueblo, Colorado, is a Reform Jewish synagogue which was built in 1900. It is located in one of the oldest neighborhoods in the city of Pueblo. The Temple Emanuel was listed on the National Register of Historic Places (NRHP) in 1996, for the architecture.

The Nathaniel W. Duke House, at 1409 Craig St. in Pueblo, Colorado, was built in 1889. It was listed on the National Register of Historic Places in 1985.It was deemed significant as a good example of Queen Anne-style residential architecture, and for its association with pioneer-era businessman Nathaniel W. Duke (1846-1893).The house was designed by Denver architect Fred A. Hale and is prominent as the largest house in the Craig subdivision. It was built by contractors Pierson and Rinetsen under supervision of Weston & Bicknell as Superintendent of Construction.Duke moved to Pueblo in 1868 and joined the Thatcher Brothers in their general mercantile store. In 1879, Duke ran for county treasurer and remained in that office for two years. He then formed a partnership with William Orman in the Dexter Livery Stable. Fire destroyed the stable in July, 1875, and the firm was dissolved. In 1876, Duke entered into the grocery business with Charles Henkel as a junior partner with the firm known as the Charles Henkel and Company. As the business grew it evolved into a wholesale grocery operation. Together, Henkel and Duke built one of the most successful wholesale grocery businesses in southern Colorado, serving both Colorado and adjacent territories. The firm carried a stock of $200,000 and did an annual business of one quarter of a million dollars. Duke died on December 18, 1893. In his obituary he was eulogized as "one of the best known wholesale grocerymen in the country, his acquaintance being large throughout the East and West. As a businessman, he showed himself to be possessed of unusual judgement and sagacity. In his death, Pueblo loses one of her most highly respected and public spirited citizens" (Pueblo Daily Chieftain, December 18, 1893, p.5). In a letter written by Charles Henkel to the Southern Colorado Pioneers Association on May 25, 1917, Mr, Henkel referred to Duke as "one of the most brilliant businessmen in the State of Colorado." Following his death, the Duke family continued in the business with Mr. Henkel. Ella, his wife, and son Thomas became officers, and the firm became known as the Henkel-Duke Mercantile Company.Its tower provides fine views.

The Colorado State Mental Hospital at Pueblo was Colorado state's largest institution dedicated to caring for the mentally ill until 1962, when the process of regional decentralization resulted in it only serving the Pueblo area. The hospital itself first began operating in the 1880s. The main building of the hospital was opened on November 20, 1883. This early iteration of the Asylum was capable of holding 210 people across 6 wards and was generally equally divided between male and female patients. Asylum leadership consistently had to deal with overcrowding. To combat this, many additions were made to the hospital throughout the late 19th and early 20th centuries. In early 1889 it was reported in the Leadville Daily Times that the hospital had requested a total of $93,436.27 for new constructions on their grounds. These additions did not permanently solve the overcrowding issue, which was addressed through new constructions up until the 1960s. In 1946, the hospital had 4,811 patients enrolled. The majority of the patients came from Colorado's three largest cities, Denver, Pueblo, and Colorado Springs, which made up over half of those receiving care at the hospital and their respective counties totaled 3,183 patients. Patient care and the constant need for new constructions led the hospital towards a difficult financial situation. In 1947, a special legislative committee indicated that they would be selling the Woodcroft portion of the hospital due to its poor condition and financial burdenThe hospital continued to expand up until 1962, when geographic decentralization led to the establishment of regional treatment hospitals that were located close to the patients home community. This resulted in smaller hospital units that were more able to provide intimate and personalized care. Currently, the hospital encompasses a 300-acre campus with numerous buildings for mental healthcare. In 2022, the hospital is capable of caring for 516 patients and cares for children, adults, and the elderly. The hospital also cares for those who were deemed incompetent after criminal proceedings or are still pending such a judgement.

Pueblo School District 60 (D60), formerly Pueblo City Schools, is a school district serving Pueblo, Colorado. Its headquarters, the Administrative Services Center, are in Pueblo.

The Cathedral of the Sacred Heart or Sacred Heart Church is a historic church located at 414 West 11th Street in Pueblo, Colorado. It is the mother church of the Diocese of Pueblo. Its building, built in 1912-13, was listed on the National Register of Historic Places in 1989. It was deemed "an outstanding example of Gothic Revival architecture, includes an inspiring spire, pointed arch windows, and soaring interior vaulting".

The Pueblo County Courthouse is a historic courthouse in Pueblo, Colorado. The building, designed by New Yorker Albert Ross, and executed in 1908–12 in brick and white sandstone, was the third building to serve as the county courthouse. It has a very unusual double dome, i.e. there is an area between interior and exterior domes.The stones are set in stretcher bond.Portions of its interior are decorated by stencil wall painting and murals by J. Charles Schnorr, some with gold leaf work. These decorate the rotunda walls, the County Commissions' Chambers and the building's three courtrooms, including their canvas ceilings of the courtrooms. Schnorr was a regionally known painter who lived in Pueblo. He studied in New York, Vienna, and Paris. The pediment over the main entry has an elaborate tympanum.

La Vista Correctional Facility (LVCF) is a state prison located in Pueblo, Pueblo County, Colorado, owned and operated by the Colorado Department of Corrections. The facility partially opened in April 2006, ramping up to its maximum capacity of 564 inmates. La Vista is primarily a medium security facility for women. LVCF formerly housed a small number of transgender inmates and a small number of male inmates with medical conditions that require constant care or hospice; however, they were moved to Colorado Territorial Correctional Facility. LVCF also has a small Administrative Segregation (AdSeg, or solitary confinement) tower where LVCF female inmates, as well as male and female offenders from the Youthful Offender System (YOS) prison, can be temporarily housed for administrative or behavioral issues. All new YOS offenders spend the first 28 days of their YOS sentence in LVCF's AdSeg tower, where they undergo the orientation training phase of (YOS).Since 2006 La Vista has implemented a program where inmates may volunteer to work in the surrounding farm fields at harvest time, replacing foreign migrant labor, which has been increasingly hard to find due to immigration crackdowns. As of 2010 farmers were paying the DOC $9.60 per person per hour. A portion of that rate goes to the inmate.