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The Soldiers' Home in Holyoke is a full-service veterans center and hospital located in Holyoke, Massachusetts, which maintains 247 beds in its main nursing facility, and a separate domiciliary care building with 30 full-time residents. The facility provides long-term care and outpatient medical services, as well as dental and social services, and programming and events for veterans. Operated by the Massachusetts Department of Veterans' Services, it is inspected annually by both the state and the United States Department of Veterans' Affairs.In April 2020, at least 68 veterans—nearly 30 percent of the home's residents—died of COVID-19 in the deadliest outbreak at a long-term care facility in the U.S. during the COVID-19 pandemic. A subsequent independent report found that poor infection control practices and chaotic decisionmaking promoted the spread of the virus within the home. In response to the outbreak the facility is implementing a $2 million overhaul to redesign its floors, reducing the number of beds to 160 in compliance with distancing guidelines.

Holyoke Community College (HCC) is a public community college in Holyoke, Massachusetts. It offers associate degrees and certificate programs, as well as a transfer program for students to earn credits for transfer to other colleges. It was the first community college established in Massachusetts, as it was founded by the city's school board in 1946, while others were subsequently chartered under state jurisdiction after 1960. HCC currently offers more than 100 associate degree and certificate options, as well as adult basic education/GED programs, education and training for business and industry, and noncredit community education classes. In a 2016 report on community colleges in the United States, the Aspen Institute and Columbia University's Community College Research Center cited HCC as among 2-year community colleges with best practices for student transfers to 4 year institutions such as the University of Massachusetts Amherst. Additionally among the 15 community colleges in Massachusetts, HCC has the highest percentage of student graduates completing associate degrees and certificate programs.HCC is located on a 135-acre (0.55 km2) campus, and has satellite locations throughout the Pioneer Valley, including the HCC-MGM Culinary Arts Institute, the only culinary arts program at a Massachusetts college accredited by the American Culinary Federation.The college participates in the Commonwealth Dual Enrollment Partnership (CDEP) and allows high school applicants to opt for full or part-time coursework to receive both high school and transferable college credit. Enrolled students may also complete certain coursework at Mount Holyoke and Smith College, as both share faculty with the community college. Holyoke Community College is accredited by the New England Commission of Higher Education.

First Lutheran Church and School (FLCS) is a member of the Lutheran Church–Missouri Synod located at 1810 Northampton St. in Holyoke, Massachusetts. The school is a Christian-based Pre-K to 8th grade school with around 100 students.

The Walter Scott Memorial Tower, often referred to as Scott Tower, is a stone tower built in 1940 in Holyoke, Massachusetts, United States. The tower was constructed in Anniversary Hill Park and was named after the original owner and donor of the land Colonel Walter Scott. Improvements in the 1940s by the Civilian Conservation Corps and Works Progress Administration allowed for access via trails and footbridges, but since the 2000s the tower has been subject to graffiti and vandalism. Further improvements in 2023 were slated to allow for wheelchair access to the tower.

Holyoke Medical Center, formerly known as Holyoke City Hospital, is a full-service, community and regional non-profit medical center located in Holyoke, Massachusetts. Holyoke Medical has 198 beds in the main hospital and runs a comprehensive healthcare system that includes the VNA, River Valley Counseling Center and Western Mass Physician Associates, a physician practice group. The service area for hospital covers Greater Holyoke area, with towns in both Hampshire and Hampden County including Holyoke, Chicopee, South Hadley, Granby, Easthampton, Southampton, West Springfield, and Belchertown.

Whiting Farms is a neighborhood in Holyoke, Massachusetts, located to the southwest of the city center, approximately 2 miles (3.2 km) from downtown. Following the construction of Whiting Farms Road in 1961, the area was developed as a residential and commercial area in the 1960s and 1970s. Its name derives from its original use as site of the farm of William Whiting, where the former mayor and papermaker bred a prizewinning herd of Jersey cattle in the late 19th and early 20th century, many of which were sold for breeding to all parts of the country. A disastrous fire caused by arson in 1919 would kill off the entire herd of 75 head, and following this the farm, then-owned by William F. Whiting, became largely defunct. At the end of the Second World War it was proposed that the property be redeveloped into an airpark, however these plans would never come to fruition. Shortly after another case of arson in 1967 which destroyed a remaining barn, the property began to see the medium-density residential development that characterizes it today, with the First Whiting Farms Cooperative Housing breaking ground later that year. Initially criticized as the "Road to Nowhere" during Samuel Resnic's administration in the early 1960s, Whiting Farms Road today serves as a major artery for retail businesses and traffic to I-91 in the area.

Elmwood is a neighborhood in Holyoke, Massachusetts located to the south of the city center, approximately 1 mile (1.6 km) from downtown. Elmwood is historically Holyoke's oldest village; predating the construction of the Hadley Falls Dam, it originated as part of the 3rd parish ("Ireland Parish") of West Springfield, and originally was known as Baptist Village as Holyoke's first and oldest congregation is the First Baptist Church, formally established in 1803, but maintaining a meetinghouse since 1792.: 108  Today the neighborhood contains many historic Victorian houses and about 510 acres (210 ha) of mixed residential and commercial zoning, as well as Holyoke High School, William R. Peck Middle School, Fitzpatrick Ice Skating Rink, and Mackenzie Stadium.

Holyoke High School is a public high school in western Massachusetts, United States that serves the City of Holyoke. Since 2015, the school, along with the district, has been in state receivership and through a series of changes in practices, such as innovative restorative justice disciplinary programs, has seen marked improvement in student retention and graduation rates. In the 2017-2018 school year Holyoke High received higher combined SAT scores than the average for schools in Boston, Worcester, and Springfield.

Oakdale is a neighborhood in Holyoke, Massachusetts located to the west of the city center, adjacent to downtown. Developed as a streetcar suburb in the late nineteenth century, today the neighborhood contains many Victorian houses, and about 460 acres (190 ha) of mixed residential and commercial zoning, as well as Forestdale Cemetery, Saint Jerome Cemetery, Rohan Park, and Holyoke Medical Center.

Mackenzie Stadium is a baseball venue located in Holyoke, Massachusetts. It was home to the Holyoke Millers and today is used by both the Valley Blue Sox of the New England Collegiate Baseball League (since 2008) and the Elms College Blazers of the New England Collegiate Conference (since 2005). It was built in 1933 and has a capacity of 4,100 people.Mackenzie Stadium hosted the 2009 NECBL All-Star Game on July 18, 2009. The game, attended by an All-Star Game record 4,906 fans, was won by the host West Division 6–5.

Forestdale Cemetery is a public secular cemetery located in Holyoke, Massachusetts. The cemetery was officially organized on November 1, 1860, after a town meeting in October of that year designated a sum of $1,500 (approx. $41,000 2016 USD) for the purchase of land; contributions for this land came from the Holyoke Water Power Company as well as local mills, with the acquisitions presided over by Jones S. Davis, engineer of Lyman Mills. The cemetery acquisitions were completed and dedicated on June 22, 1862 with speeches by Amherst professor J.G. Voss and one of Holyoke's founding figures, George C. Ewing. The cemetery, built during a time of great interest in landscape architecture, contains a deliberately chosen layout of ornamental trees and shrubs.In addition to the many founding families of Holyoke, the cemetery is the resting place of many of the city's mayors and city officials, including William Whiting II and Roswell P. Crafts. Serving as a common burial ground for all citizens, it also contains a potter's field for indigents.

Springdale is a neighborhood in Holyoke, Massachusetts located to the south of the city center, approximately 1 mile (1.6 km) from downtown, on the banks of the Connecticut River. The neighborhood features Springdale Park, originally known as Riverside Park, which was designed by the influential Olmsted Brothers landscape architecture firm, as well as light industry and machine shops, residential housing, and the central supply warehouse of Holyoke Public Schools. The mixed zoning neighborhood was developed as a streetcar suburb by brickmaker John J. Prew, who gave the area its name and devised the first street plans and building lots for the area in 1887 as housing for millworkers of South Holyoke. Since 1984, Springdale Park has hosted the city's annual Western Massachusetts Puerto Rican Parade, a three-day annual event in June celebrating the city's Latin culture and music.