Duke Homestead and Tobacco Factory

The North Carolina School of Science and Mathematics (NCSSM) is a two-year, public residential high school with two physical campuses located in Durham, North Carolina and Morganton, North Carolina that focuses on the intensive study of science, mathematics and technology. It accepts rising juniors from across North Carolina and enrolls them through senior year. Although NCSSM is a public school, enrollment is extremely selective, and applicants undergo a competitive review process for admission. NCSSM is a founding member of the National Consortium of Secondary Stem Schools (NCSSS) and a constituent institution of the University of North Carolina system.

Watts Hospital, located in Durham, North Carolina was the city's first hospital, operating between 1895 and 1976. The hospital opened in 1895, funded entirely by George W. Watts, as a private, 22-bed, modern hospital dedicated to the care of Durham's white citizens and offered free care to those unable to pay. The hospital became public in 1953 and closed 1976, when Durham County General Hospital opened. The grounds and buildings of the hospital's 1909 campus were converted to become the North Carolina School of Science and Mathematics, which began classes in 1980.

Lakewood Park Historic District is a national historic district located at Durham, Durham County, North Carolina. The district encompasses 76 contributing buildings in a predominantly residential section of Durham. They were built between 1902 and 1952 and include notable examples of Queen Anne and Bungalow / American Craftsman style architecture.It was listed on the National Register of Historic Places in 2003.

Watts–Hillandale Historic District, also known as Club Acres and Englewood, is a national historic district located at Durham, Durham County, North Carolina. The district encompasses 446 contributing buildings, 2 contributing sites, and 2 contributing structures in a predominantly residential section of Durham. They were built after 1909 and include notable examples of Mission Revival and Colonial Revival style architecture. Located in the district is the separately listed Watts Hospital complex.It was listed on the National Register of Historic Places in 2001.The neighborhood is home to active community members and leaders. Halloween, particularly on Club Boulevard, is full of trick-or-treaters from across the city, with homes on the street giving out treats to 1,000 or more children who visit for the festivities.

Durham County Memorial Stadium is an 8,500-seat multi-purpose stadium located in Durham, North Carolina. Originally built in 1958, the stadium underwent significant renovations in 2010 that updated the facility to include an artificial turf lined for soccer, football and lacrosse and a track and field facility with an eight lane track. Durham County Memorial Stadium is the home field of Northern Durham High School Football, Carolina Flyers of the AUDL and Tobacco Road FC of USL-2. The stadium is also used as a special events facility hosting local, regional and national events. The stadium hosted Shaw University Football from 2007 to 2018, and again after the 2022 season. Shaw also hosts a majority of their men's and women's soccer matches at the stadium despite the school's location in neighboring Wake County. Durham County Memorial Stadium is managed by the Durham County Memorial Stadium Authority and owned by the County of Durham.

Northgate Mall was a regional shopping mall located off Interstate 85 and Gregson Street (exit 176) in northern Durham, North Carolina, United States. The mall is in close proximity to Duke University and downtown Durham, between the Trinity Park and Walltown neighborhoods.

Duke Regional Hospital (DRH), located in northern Durham, North Carolina is a general-services hospital that has been part of the Duke University Health System since 1998. The hospital has 369 beds and over 500 physicians on the medical staff, and has a certified Level II Intensive Care Nursery.

WTIK (1310 AM) is a radio station broadcasting a Regional Mexican format. Licensed to Durham, North Carolina, United States, the station serves the Triangle area. The station is currently owned by Claudino Bonerges, Ashley Padilla Ayala, Brian Padilla, and Alexis Padilla, through licensee A&B Media LLC.

The George Wall House, also called Old Man Wall's House, is a historic shotgun house in the Walltown Neighborhood in Durham, North Carolina.

The Museum of Life and Science—previously known as the North Carolina Museum of Life and Science and the NC Children's Museum—is an 84-acre (340,000 m2) science museum located in Durham, North Carolina, United States. The museum campus lies in the midst of the Northgate Park neighborhood, bisected by Murray Avenue. The main building is located on the north tract, along with the Butterfly House, Hideaway Woods, Farmyard, Sprout Cafe, Explore the Wild nature park, Catch the Wind, Dinosaur Trail, and the 2 ft (610 mm) narrow gauge Ellerbe Creek C.P. Huntington train ride. The museum features both indoor and outdoor learning environments. The southern tract is now largely devoted to parking and administrative buildings, including a parking deck completed in early 2018. Prior to the construction of the new main building in the early 1990s, the structures on the southern tract contained the bulk of the museum's exhibit space.

North Carolina Specialty Hospital (NCSH) is a specialty hospital located in northern Durham, North Carolina. The hospital provides orthopaedic, ophthalmogic, otolaryngology (ENT), plastic, and general surgery care, as well as pain management techniques and podiatric care. NCSH is the oldest hospital in Durham, dating back to 1926, when it was formed as an eye, ear, nose, and throat hospital originally known as McPherson Hospital, named after Dr. Samuel McPherson, an EENT specialist. In the early-1990s, the hospital was renamed as the North Carolina Eye and Ear Hospital. It was located at the time in its original building in downtown Durham, near the East Campus of Duke University. In May 2005, NCSH moved to its current location in northern Durham, and was renamed as North Carolina Specialty Hospital in 2000. In 2009, North Carolina Specialty Hospital was named the top hospital in North Carolina, and among the top 10 in the United States, for its patient care ratings, per the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS), a division of the Centers for Medicare & Medicaid Services (CMS). NCSH is jointly owned by National Surgical Hospitals (NSH), and physicians from North Carolina Eye and Ear Associates and Triangle Orthopaedic Associates.

WXDU (88.7 FM) is a non-commercial campus radio station broadcasting a college radio format. Licensed to Durham, North Carolina, United States, the station serves the Research Triangle area. The station is owned by Duke University.