Otto and Hilda Gretzinger House

The North Michigan Street-North Superior Street Historic District is located in De Pere, Wisconsin.

The North Broadway Street Historic District is a 28 acres (11 ha) historic district in De Pere, Wisconsin which was listed on the National Register of Historic Places in 1983. It included 47 contributing buildings and seven non-contributing ones.The district is located on the north side of De Pere. Contributing buildings within its boundaries were constructed from 1836 to 1923 and were built in a variety of architectural styles.Buildings deemed to have "pivotal" historic importance within the district (with building # as in NRHP document, and photo # as in linked photos) are: Kellogg-McGeehan Residence, 515 N. Broadway St., a two-story frame house with, on its front facade, a projecting pavilion and a full-length one-story veranda J.S. Chase Residence, 602 N. Broadway St., a two-and-a-half-story Queen Anne house with a square tower. Its "architectural character" has been "compromised by siding" H.J. Wheeler Residence, 620 N. Broadway St., a brick house with a shingled mansard roof and a recessed corner tower (building #33, photo #34) F.A. Dunham Residence, 639 N. Broadway St., a two-story-plus-attic house with a tower. Its interior was remodeled in 1925 to Stick/Shingle fashion. Randall Wilcox Residence, 707 N. Broadway St., with two-story central flanked by one-story wings. It has Greek Revival-style entablatures. E.E. Bolles Residence, 721 N. Broadway St., built as a large Queen Anne house, but its picturesque massing was reduced by early 20th-century renovations. It has a historic one-story carriage house at the rear. A.G. Wells Residence, 807 N. Broadway St., a large two-and-a-half-story "English eclectic manor of stone, with stucco and wood trim" John P. Dousman Residence, 813 N. Broadway St., a late Queen Anne cottage John S. Gittens Residence, 823 N. Broadway St., built as a two-and-a-half-story gambrel roof Colonial Revival, it received a gable-front compatible addition E.P. Smith Residence, 903 N. Broadway St., a red brick house with original interior woodwork and Adamsesque fireplace (building #23, photo #21) Capt. Joseph G. Lawton Residence, 935 N. Broadway St., a stone Italianate house whose appearance was accomplished in 1914 and 1920 remodelings. An earlier 1858 stone house, of Captain Joseph Lawton, appears not to have survived within. Gustave H. Fleck Residence, 432 N. Wisconsin St., with elements of Queen Anne and Colonial Revival style F.E. White Residence, 421 Cass St., a two-story frame Greek Revival house with a veranda having square columns topped by square Doric capitals. Jacob Falk Residence, 321 N. Wisconsin St., a Queen Anne cottage with a corner tower and a veranda.

Union House Hotel is located in De Pere, Wisconsin. It was added to the National Register of Historic Places in 2003.

The John Baeten Store is located in De Pere, Wisconsin.

The mission of St. Francis Xavier was a seventeenth-century Jesuit mission located on the rapids of the Fox River near De Pere, Wisconsin.It was founded in 1671 by Claude Allouez to proselytize the native peoples of the western Great Lakes. In 1684 a chapel measuring 70'x40' and seating six-hundred was completed under the direction of Father Verboort to serve an expanding Catholic population. The mission was used as a base of operations by Nicolas Perrot in his explorations of the Upper Midwest in the 1680s. In 1686 he made a present of a silver ostensorium to the mission which was rediscovered by workmen digging a foundation in 1802. In 1687 the mission of St. Francis Xavier was destroyed in an Iroquois attack.

The De Pere Lock and Dam Historic District is located in De Pere, Wisconsin. It was added to the State Register of Historic Places in 1992 and to the National Register of Historic Places the following year.

St. Norbert Abbey is a Roman Catholic monastery of Canons Regular of Premontre, located in De Pere, Wisconsin. The Abbey is named after Saint Norbert of Xanten (c. 1180–1134), the founder of the order, after whom, members are known as, "Norbertines". St. Norbert Abbey was established in 1898 by Norbertines from Berne Abbey in the Netherlands. St. Norbert's is the oldest religious community of its kind the United States, serving as the Mother Canonry to Norbertines across North America. The Abbey is situated on 160 acres (0.65 km2) of land east of the Fox River, south of Green Bay, Wisconsin, within the Roman Catholic Diocese of Green Bay.The members of the community combine a monastic-style life with the active ministry of ordained priests. Priests and Brothers of the Abbey serve in parish churches, at parochial schools and at St. Norbert College, whose founder, Bernard Pennings, was the First Abbot the community.

The Henry and Mary Heyrman House is located in De Pere, Wisconsin.

The Old Nicolet High School is a historic school located in De Pere, Wisconsin, USA.

The De Pere Public Library is located in De Pere, Wisconsin, USA. It was added to the National Register of Historic Places for its architectural and educational significance in 2002.

St. Norbert College (SNC) is a private Norbertine liberal arts college in De Pere, Wisconsin. Founded in October 1898 by Abbot Bernard Pennings, a Norbertine priest and educator, the school was named after Saint Norbert of Xanten. In 1952, the college became coeducational. As of April 2023, the school's enrollment is 2,009 students.

The National Shrine of St. Joseph is located in De Pere, Wisconsin, a few miles from the city of Green Bay, in the Roman Catholic Diocese of Green Bay. The Shrine is located at 123 Grant Street, De Pere, Wisconsin, on the St. Norbert College campus.